3-羟基-5-苯基戊醛 | 1035811-70-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-羟基-5-苯基戊醛
• 英文名称: 3-Hydroxy-5-phenyl-pentanal
• 英文别名: 3-Hydroxy-5-phenylpentanal；3-hydroxy-5-phenylpentanal
• CAS: 1035811-70-1
• 化学式: C₁₁H₁₄O₂
• 分子量: 178.231
• InChiKey: NQIJZKOAQOBVIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-羟基-5-苯基戊醛 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 生成 5-phenylpentane-1,3-diol
  参考文献：
  名称：

  Enantioselective chiral borane-mediated aldol reactions of silyl ketene acetals with aldehydes. The novel effect of the trialkysilyl group of the silyl ketene acetal on the reaction course

  摘要：

  Highly enantioselective aldol reactions of silyl ketene acetals with a variety of aldehydes were achieved by using chiral boranes prepared from the sulfonamides of alpha-amino acids.

  DOI：

  10.1021/jo00007a003
• 作为产物：
  描述：

  1-(tert-Butyl-dimethyl-silanyloxy)-1-ethoxy-5-phenyl-pentan-3-ol 在 溶剂黄146 作用下， 以 水 为溶剂， 反应 0.17h， 生成 3-羟基-5-苯基戊醛
  参考文献：
  名称：

  Enantioselective chiral borane-mediated aldol reactions of silyl ketene acetals with aldehydes. The novel effect of the trialkysilyl group of the silyl ketene acetal on the reaction course

  摘要：

  Highly enantioselective aldol reactions of silyl ketene acetals with a variety of aldehydes were achieved by using chiral boranes prepared from the sulfonamides of alpha-amino acids.

  DOI：

  10.1021/jo00007a003

文献信息

• Synthetic Studies Towards the Synthesis of 6-Substituted 3-Fluoro-5,6-dihydropyran-2-ones
  作者：Samir Mandal、Apurba Sarkar、Puskin Chakraborty、Ashoke Chattopadhyay

  DOI：10.1055/s-0036-1588534

  日期：2018.1

  The synthesis of 6-substituted 3-fluoro-5,6-dihydropyran-2-ones under mild conditions is described. The key step of the synthesis involves a Julia–Kocienski olefination.

  描述了在温和条件下合成 6-取代 3-fluoro-5,6-dihydropyran-2-ones。合成的关键步骤涉及 Julia-Kocienski 烯化。
• Enantioselective chiral borane-mediated aldol reactions of silyl ketene acetals with aldehydes. The novel effect of the trialkysilyl group of the silyl ketene acetal on the reaction course
  作者：Syunichi Kiyooka、Yuichi Kaneko、Misako Komura、Hidehito Matsuo、Masahito Nakano

  DOI：10.1021/jo00007a003

  日期：1991.3

  Highly enantioselective aldol reactions of silyl ketene acetals with a variety of aldehydes were achieved by using chiral boranes prepared from the sulfonamides of alpha-amino acids.