t-butyl-dimethylsilyloxy-2,6-dipropyl-4-hydroxymethyl benzene | 137421-55-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: t-butyl-dimethylsilyloxy-2,6-dipropyl-4-hydroxymethyl benzene
• 英文别名: {4-(tert-butyldimethylsilyloxy)-3,5-dipropylphenyl}methanol；4-tert-butyldimethylsilyloxy-3,5-dipropylbenzyl alcohol；(4-{[tert-Butyl(dimethyl)silyl]oxy}-3,5-dipropylphenyl)methanol；[4-[tert-butyl(dimethyl)silyl]oxy-3,5-dipropylphenyl]methanol
• CAS: 137421-55-7
• 化学式: C₁₉H₃₄O₂Si
• 分子量: 322.563
• InChiKey: DWSWNGWLPPWIGX-UHFFFAOYSA-N

物化性质

• 沸点：
  387.5±42.0 °C(Predicted)
• 密度：
  0.937±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.47
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  t-butyl-dimethylsilyloxy-2,6-dipropyl-4-hydroxymethyl benzene 在 四丁基氟化铵 、 potassium carbonate 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 、 丙酮 为溶剂， 生成 3-[4-((1-carbomethoxy-1-phenyl)methoxy)-3,5-dipropylphenylmethyl]-5,7-dimethyl-2-ethyl-3H-imidazo-[4,5-b]pyridine
  参考文献：
  名称：

  （二丙基苯氧基）苯乙酸：新一代非肽血管紧张素II受体拮抗剂。

  摘要：

  DOI：

  10.1021/jm00075a033
• 作为产物：
  描述：

  methyl 4-tert-butyldimethyl-silyloxy-3,5-dipropylbenzoate 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 以92%的产率得到t-butyl-dimethylsilyloxy-2,6-dipropyl-4-hydroxymethyl benzene
  参考文献：
  名称：

  （二丙基苯氧基）苯乙酸：新一代非肽血管紧张素II受体拮抗剂。

  摘要：

  DOI：

  10.1021/jm00075a033

文献信息

• Biphenyl compounds useful or endothelin antagonists
  申请人：Merck & Co., Inc.

  公开号：US05565485A1

  公开（公告）日：1996-10-15

  Phenoxyphenylacetic acids and derivatives of the general structural formula I ##STR1## have endothelin antagonist activity and are useful in treating cardiovascular disorders, such as hypertension, postischemic renal failure, vasospasm, cerebral and cardiac ischemia, myocardial infarction, endotoxic shock, benign prostatic hyperplasia, inflammatory diseases including Raynaud's disease and asthma.

  苯氧苯乙酸及其衍生物具有一般结构式I的内皮素拮抗活性，并可用于治疗心血管疾病，如高血压、缺血后肾功能衰竭、血管痉挛、脑和心脏缺血、心肌梗死、内毒素休克、良性前列腺增生、包括雷诺氏病和哮喘在内的炎症性疾病。
• NOVEL ALPHA-PHENOXYBENZENEACETIC ACID DERIVATIVE AND PHARMACEUTICAL PREPARATION COMPRISING SAME
  申请人：Miura Toru

  公开号：US20120046308A1

  公开（公告）日：2012-02-23

  An α-phenoxybenzeneacetic acid derivative represented by general formula (I), which has both an angiotensin II receptor antagonistic activity and a PPARγ activation activity and is useful as a prophylactic and/or therapeutic agent for hypertension, metabolic syndrome or the like, a salt of the derivative, or a solvate of the derivative or the salt; and a pharmaceutical composition containing the derivative, the salt or the solvate. [In the formula, Q represents a group represented by formula (II) or (III) [wherein R 1 and R 1′ independently represent a C 1-6 alkyl group; R 2 and R 2′ independently represent a substituted or unsubstituted C 1-6 alkyl group; R 3 represents a hydrogen atom, a substituted or unsubstituted C 1-6 alkyl group, or a group represented by formula (IV) [wherein X and Y independently represent CH or N; Z represents a C 1-6 alkylene chain, or the like; R 11 represents a hydrogen atom, a C 6-10 aryl group, or the like; and m represents 0 or 1]; and R 4 represents a substituted C 1-6 alkyl group]; R 5 and R 6 independently represent a C 1-6 alkyl group: R 7 represents a carboxyl group, or the like; R 8 , R 9 and R 10 independently represent a hydrogen atom, a halogen atom, or the like; and n represents an integer of 1 to 3.]

  通用公式（I）表示的α-苯氧基苯乙酸衍生物，具有血管紧张素II受体拮抗活性和PPARγ激活活性，并可用作高血压、代谢综合征等的预防和/或治疗剂，或者衍生物的盐，或者衍生物或盐的溶剂；以及含有该衍生物、盐或溶剂的药物组合物。【在公式中，Q代表由公式（II）或（III）表示的基团【其中R1和R1'分别代表C1-6烷基基团；R2和R2'分别代表取代或未取代的C1-6烷基基团；R3代表氢原子、取代或未取代的C1-6烷基基团，或由公式（IV）表示的基团【其中X和Y独立地代表CH或N；Z代表C1-6烷基链等；R11代表氢原子、C6-10芳基基团等；m代表0或1】；而R4代表取代的C1-6烷基基团】；R5和R6独立地代表C1-6烷基基团；R7代表羧基等；R8、R9和R10独立地代表氢原子、卤素原子等；n代表1到3的整数。】
• Phenoxyphenylacetic acid derivatives
  申请人：Merck & Co., Inc.

  公开号：US05767310A1

  公开（公告）日：1998-06-16

  Phenoxyphenylacetic acids and derivatives of general structural formula (I) have endothelin antagonist activity and are useful in treating cardiovascular disorders, such as hypertension, postischemic renal failure, vasospasm, cerebral and cardiac ischemia, myocardial infarction, endoxic shock, benign prostatic hyperplasia, inflammatory diseases including Raynaud's disease and asthma.

  苯氧苯乙酸及其一般结构式(I)的衍生物具有内皮素拮抗活性，并可用于治疗心血管疾病，如高血压、缺血后肾衰竭、血管痉挛、脑和心脏缺血、心肌梗死、内毒性休克、良性前列腺增生、包括雷诺氏病和哮喘在内的炎症性疾病。
• Quinoline angiotensin II antagonists incorporating a substituted benzyl
  申请人：Merck & Co., Inc.

  公开号：US05246944A1

  公开（公告）日：1993-09-21

  Substituted quinolines and azaquinolines (1,5-naphthridines) attached through an oxymethylene bridge to novel substituted phenyl derivatives of the Formula I, are useful as angiotensin II antagonists. ##STR1##

  通过氧甲基桥连接到新的取代苯基衍生物的喹啉和氮杂喹啉（1,5-萘啶）可作为血管紧张素II拮抗剂的有用替代物。##STR1##
• Angiotensin II antagonists incorporating a substituted benzyl element
  申请人：Merck & Co., Inc.

  公开号：US05449682A1

  公开（公告）日：1995-09-12

  Substituted heterocycles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I are useful as angiotensin II antagonists. ##STR1## wherein the substituents are as defined in the claims.

  通过甲基桥连接到新的取代苯基衍生物的取代杂环可以作为血管紧张素II拮抗剂，其中取代基如权利要求所定义。 ## STR1 ##