(4S)-4-[(4S)-2-oxo-3-(2-phenylacetyl)-1,3-oxazolidin-4-yl]-3-(2-phenylacetyl)-1,3-oxazolidin-2-one | 285979-97-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4S)-4-[(4S)-2-oxo-3-(2-phenylacetyl)-1,3-oxazolidin-4-yl]-3-(2-phenylacetyl)-1,3-oxazolidin-2-one
• CAS: 285979-97-7
• 化学式: C₂₂H₂₀N₂O₆
• 分子量: 408.411
• InChiKey: ZZJRPFZNISMXQY-QZTJIDSGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  93.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (4S)-4-[(4S)-2-oxo-3-(2-phenylacetyl)-1,3-oxazolidin-4-yl]-3-(2-phenylacetyl)-1,3-oxazolidin-2-one 、 碘甲烷 在 六甲基磷酰三胺 、 sodium hexamethyldisilazane 作用下， 以 四氢呋喃 为溶剂， 生成 、 、 (4S)-4-[(4S)-2-oxo-3-[(2S)-2-phenylpropanoyl]-1,3-oxazolidin-4-yl]-3-[(2S)-2-phenylpropanoyl]-1,3-oxazolidin-2-one
  参考文献：
  名称：

  Synthesis of the first water-soluble C 2 -symmetric bis(oxazolidinone) as a potential bifunctional chiral auxiliary

  摘要：

  The first water-soluble C-2-symmetric bis(oxazolidinone) 1, a potential bifunctional chiral auxiliary, has been synthesized via regioselective intramolecular cyclization of a biscarbamate. The sodium enolate derived from N,N'-di(phenylacetyl)bis(oxazolidinone) 7 reacts with methyl iodide with high facial selectivity (95:5). (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(00)00086-0
• 作为产物：
  描述：

  (5S,5'S)-N,N-dibenzyl-5,5'-bis(oxazolidin-2-one) 在 氨 、 sodium 、 三甲基乙酰氯 、 三乙胺 作用下， 以 甲苯 为溶剂， 生成 (4S)-4-[(4S)-2-oxo-3-(2-phenylacetyl)-1,3-oxazolidin-4-yl]-3-(2-phenylacetyl)-1,3-oxazolidin-2-one
  参考文献：
  名称：

  Synthesis of the first water-soluble C 2 -symmetric bis(oxazolidinone) as a potential bifunctional chiral auxiliary

  摘要：

  The first water-soluble C-2-symmetric bis(oxazolidinone) 1, a potential bifunctional chiral auxiliary, has been synthesized via regioselective intramolecular cyclization of a biscarbamate. The sodium enolate derived from N,N'-di(phenylacetyl)bis(oxazolidinone) 7 reacts with methyl iodide with high facial selectivity (95:5). (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(00)00086-0

文献信息

• Synthesis of the first water-soluble C 2 -symmetric bis(oxazolidinone) as a potential bifunctional chiral auxiliary
  作者：Sang-gi Lee、Chung Woo Lim、Dong Chan Kim、Jae Kyun Lee

  DOI：10.1016/s0957-4166(00)00086-0

  日期：2000.4

  The first water-soluble C-2-symmetric bis(oxazolidinone) 1, a potential bifunctional chiral auxiliary, has been synthesized via regioselective intramolecular cyclization of a biscarbamate. The sodium enolate derived from N,N'-di(phenylacetyl)bis(oxazolidinone) 7 reacts with methyl iodide with high facial selectivity (95:5). (C) 2000 Elsevier Science Ltd. All rights reserved.