o-Bromo-α,α-dimethylbenzyl chloride | 7073-71-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: o-Bromo-α,α-dimethylbenzyl chloride
• 英文别名: 2-(2-bromophenyl)-2-chloropropane；1-bromo-2-(α-chloro-isopropyl)-benzene；1-Brom-2-(α-chlor-isopropyl)-benzol；1-Bromo-2-(2-chloropropan-2-yl)benzene
• CAS: 7073-71-4
• 化学式: C₉H₁₀BrCl
• 分子量: 233.535
• InChiKey: JPWGCUCPEPESIM-UHFFFAOYSA-N

物化性质

• 沸点：
  58-62 °C(Press: 0.02 Torr)
• 密度：
  1.396±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  o-Bromo-α,α-dimethylbenzyl chloride 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 1.0h， 以73%的产率得到ALFA, ALFA-二甲基苄氯
  参考文献：
  名称：

  Selective halogen-lithium exchange in some secondary and tertiary (bromophenyl)alkyl halides

  摘要：

  DOI：

  10.1021/jo00336a043
• 作为产物：
  描述：

  2-(2-溴苯基)-2-丙醇 在 盐酸 作用下， 反应 5.5h， 以67%的产率得到o-Bromo-α,α-dimethylbenzyl chloride
  参考文献：
  名称：

  Selective halogen-lithium exchange in some secondary and tertiary (bromophenyl)alkyl halides

  摘要：

  DOI：

  10.1021/jo00336a043

文献信息

• Method for producing an aromatic compound having an alkyl group with at least three carbon atoms
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP0985649A2

  公开（公告）日：2000-03-15

  Aromatic compounds having an alkyl group with at least 3 carbon atoms are produced in a process comprising at least one of the following steps: (1) a step of contacting a starting material that contains an aromatic compound having a branched alkyl group with at least 3 carbon atoms, with a zeolite-containing catalyst in a liquid phase in the presence of hydrogen therein, thereby changing the position of the carbon atoms of the alkyl group bonding to the aromatic ring of the compound; (2) a step of contacting a starting material that contains an aromatic compound having a branched alkyl group with at least 3 carbon atoms, with a catalyst containing zeolite and containing rhenium and/or silver, in a liquid phase, thereby changing the position of the carbon atoms of the alkyl group bonding to the aromatic ring of the compound; (3) a step of contacting a halogenated aromatic compound having an alkyl group with at least 3 carbon atoms, with an acid-type catalyst, thereby isomerizing the compound; and (4) a step of treating a mixture of isomers of an aromatic compound having an alkyl group with at least 3 carbon atoms, with a zeolite adsorbent that contains at least one exchangable cation selected from alkali metals, alkaline earth metals, lead, thallium and silver, thereby separating a specific isomer from the isomer mixture through adsorption.

  具有至少 3 个碳原子烷基的芳香族化合物的生产工艺至少包括以下一个步骤： (1) 将含有至少 3 个碳原子的支链烷基的芳香族化合物的起始原料在液相中与含沸石的催化剂在氢存在的情况下接触，从而改变烷基的碳原子与化合物的芳香环键合的位置； (2) 将含有芳香族化合物的起始原料与含沸石和含铼和/或银的催化剂在液相中接触，该芳香族化合物具有至少 3 个碳原子的支链烷基，从而改变烷基碳原子与化合物芳香环键合的位置； (3) 将具有至少 3 个碳原子的烷基的卤代芳香族化合物与酸型催化剂接触，从而使该化合物异构化；以及 (4) 用沸石吸附剂处理具有至少 3 个碳原子的烷基的芳香族化合物的异构体混合物，该沸石吸附剂含有至少一种选自碱金属、碱土金属、铅、铊和银的可交换阳离子，从而通过吸附从异构体混合物中分离出特定的异构体。
• Rates of Solvolysis of the Halophenyldimethylcarbinyl Chlorides. The Effect of Halogen Substituents upon the Rates of Electrophilic Reactions^1-3
  作者：Herbert C. Brown、Y. Okamoto、George Ham

  DOI：10.1021/ja01565a037

  日期：1957.4
• Preparation of <i>N</i>‐(4‐Methylpentane‐2‐yl)‐<i>N</i>′‐[2‐(2‐phenylpropane‐2‐yl)]‐benzene‐1,4‐diamine
  作者：Ivica Sigmundová、Ján Uhlár、Štefan Toma

  DOI：10.1081/scc-200032408

  日期：2004.1.1

  Synthesis of N-(4- methylpentane-2-yl)-N'-[2-(2-phenylpropane-2-yl)]benzene 1,4-diamine in four steps starting from methyl 2-bromobenzoate is described. Chromatographically homogeneous product was prepared in 25% overall yield.
• PARHAM, W. E.;BRADSHER, C. K.;REAMES, D. C., J. ORG. CHEM., 1981, 46, N 23, 4804-4806
  作者：PARHAM, W. E.、BRADSHER, C. K.、REAMES, D. C.

  DOI：——

  日期：——
• US6462248B1
  申请人：——

  公开号：US6462248B1

  公开（公告）日：2002-10-08