[4-(2-Diethylamino-ethyl)-piperazin-1-yl]-(4-hydroxy-phenyl)-methanone | 183591-58-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [4-(2-Diethylamino-ethyl)-piperazin-1-yl]-(4-hydroxy-phenyl)-methanone
• 英文别名: [4-[2-(Diethylamino)ethyl]piperazin-1-yl]-(4-hydroxyphenyl)methanone
• CAS: 183591-58-4
• 化学式: C₁₇H₂₇N₃O₂
• 分子量: 305.42
• InChiKey: AVDZBQAEOOVNMK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  47
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-胍基苯甲酸甲烷磺酸盐 、 [4-(2-Diethylamino-ethyl)-piperazin-1-yl]-(4-hydroxy-phenyl)-methanone 在 吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以32%的产率得到
  参考文献：
  名称：

  Synthesis of 4-(4-guanidinobenzoyloxy)benzamides and 1-(4-guanidinobenzoyloxy)benzoyloxy acetamides as trypsin inhibitors

  摘要：

  Seventeen new compounds of 4-(4-guanidinobenzoyloxy)benzamides and 4-(4-guanidinobenzoyloxy)benzoyloxyacetamides were prepared and their inhibitory activities on trypsin, thrombin and porcine pancreatic elastase were measured. These compounds were found to be selective trypsin inhibitors with inhibiting activities from 0.44 to 43 mu M.

  DOI：

  10.1016/s0223-5234(97)89852-2
• 作为产物：
  描述：

  1-(2-二乙氨基乙基)哌嗪 在 草酰氯 、 potassium carbonate 、 三乙胺 作用下， 以 甲醇 为溶剂， 反应 3.0h， 生成 [4-(2-Diethylamino-ethyl)-piperazin-1-yl]-(4-hydroxy-phenyl)-methanone
  参考文献：
  名称：

  Synthesis of 4-(4-guanidinobenzoyloxy)benzamides and 1-(4-guanidinobenzoyloxy)benzoyloxy acetamides as trypsin inhibitors

  摘要：

  Seventeen new compounds of 4-(4-guanidinobenzoyloxy)benzamides and 4-(4-guanidinobenzoyloxy)benzoyloxyacetamides were prepared and their inhibitory activities on trypsin, thrombin and porcine pancreatic elastase were measured. These compounds were found to be selective trypsin inhibitors with inhibiting activities from 0.44 to 43 mu M.

  DOI：

  10.1016/s0223-5234(97)89852-2

文献信息

• Synthesis of 1-(4-acyloxybenzoyloxyacetyl)-4-alkylpiperazines and 1-(4-acyloxybenzoyl)-4-alkylpiperazines as inhibitors of chymotrypsin
  作者：P Zlatoidský、T Maliar

  DOI：10.1016/0223-5234(96)85875-2

  日期：1996.1

  Sixteen new esters and amides of 4-acyloxybenzoic acids were prepared and screened as chymotrypsin inhibitors. Inhibiting activities on chymotrypsin differed markedly (> 100-0.008 mu M). Compounds which contained the 4-benzoyloxyacetyl moiety showed considerably higher activity then 4-acyloxybenzamides. Compounds 1c and 11f are also weak trypsin inhibitors.
• Synthesis of 4-(4-guanidinobenzoyloxy)benzamides and 1-(4-guanidinobenzoyloxy)benzoyloxy acetamides as trypsin inhibitors
  作者：P Zlatoidský、T Maliar

  DOI：10.1016/s0223-5234(97)89852-2

  日期：1996.1

  Seventeen new compounds of 4-(4-guanidinobenzoyloxy)benzamides and 4-(4-guanidinobenzoyloxy)benzoyloxyacetamides were prepared and their inhibitory activities on trypsin, thrombin and porcine pancreatic elastase were measured. These compounds were found to be selective trypsin inhibitors with inhibiting activities from 0.44 to 43 mu M.