5-tert-butyl-2,2':5',2''-terthienyl | 118824-84-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 双噻吩和低聚噻吩
• 英文名称: 5-tert-butyl-2,2':5',2''-terthienyl
• 英文别名: 2-Tert-butyl-5-(5-thiophen-2-ylthiophen-2-yl)thiophene
• CAS: 118824-84-3
• 化学式: C₁₆H₁₆S₃
• 分子量: 304.501
• InChiKey: DBBDFTHFZHTDQS-UHFFFAOYSA-N

物化性质

• 沸点：
  401.9±45.0 °C(Predicted)
• 密度：
  1.193±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  84.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-叔丁基噻吩 、 5-iodo-2,2'-bithiophene 在 [1,3-bis(diphenylphosphino)propane]nickel(II) dichloride 正丁基锂 、 magnesium bromide 作用下， 生成 5-tert-butyl-2,2':5',2''-terthienyl
  参考文献：
  名称：

  Synthesis and characterization of alkyl-, halo- and hetero-substituted derivatives of the potent phototoxin α-terthienyl

  摘要：

  DOI：

  10.1016/s0040-4020(01)81692-6

文献信息

• Oligonucleotide compositions and methods thereof
  申请人：WAVE LIFE SCIENCES LTD.

  公开号：US10479995B2

  公开（公告）日：2019-11-19

  Among other things, the present disclosure relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same. In some embodiments, a provided chirally controlled oligonucleotide composition provides different cleavage patterns of a nucleic acid polymer than a reference oligonucleotide composition. In some embodiments, a provided chirally controlled oligonucleotide composition provides single site cleavage within a complementary sequence of a nucleic acid polymer. In some embodiments, a chirally controlled oligonucleotide composition has any sequence of bases, and/or pattern or base modifications, sugar modifications, backbone modifications and/or stereochemistry, or combination of these elements, described herein.

  除其他外，本公开涉及选择设计的手性控制寡核苷酸、手性控制寡核苷酸组合物以及制造和使用方法。在一些实施方案中，所提供的手性控制寡核苷酸组合物提供了与参考寡核苷酸组合物不同的核酸聚合物裂解模式。在一些实施方案中，所提供的手性控制寡核苷酸组合物在核酸聚合物的互补序列内提供单位点裂解。在一些实施方案中，手性控制寡核苷酸组合物具有本文所述的任何碱基序列和/或模式或碱基修饰、糖修饰、骨架修饰和/或立体化学，或这些元素的组合。
• Metal-based coordination complexes as photodynamic compounds and their use
  申请人：McFarland Sherri Ann

  公开号：US10766915B2

  公开（公告）日：2020-09-08

  Compositions of the invention include metal-based coordination complexes, which are preferably tunable photodynamic compounds. The compositions and complexes are useful as therapeutic agents and as in vivo diagnostic agents for treating or preventing diseases including those that involve hyperproliferating cells in their etiology, such as cancer. Compositions and complexes of the invention are further capable of destroying microbial cells, such as bacteria, fungi, and protozoa, and destroying viruses. The compositions and complexes are also capable of modulating cell function in other ways.

  本发明的组合物包括金属基配位复合物，它们最好是可调光动力化合物。本发明的组合物和配合物可用作治疗剂和体内诊断剂，用于治疗或预防疾病，包括在病因中涉及细胞过度增殖的疾病，如癌症。本发明的组合物和复合物还能消灭微生物细胞，如细菌、真菌和原生动物，并能消灭病毒。本发明的组合物和复合物还能以其他方式调节细胞功能。
• Oligonucleotides, compositions and methods thereof
  申请人：WAVE LIFE SCIENCES LTD.

  公开号：US11013757B2

  公开（公告）日：2021-05-25

  The present disclosure pertains to the recognition that immune responses mediated by CpG oligonucleotides can be affected by the stereochemistry of modified internucleotidic linkages such as phosphorothioates. In some embodiments, the present disclosure relates to chirally controlled CpG oligonucleotide compositions comprising CpG oligonucleotides comprising multiple modified internucleotidic linkages such as phosphorothioate linkages, wherein the oligonucleotides comprise one or more CpG region motifs having defined stereochemistry patterns of chiral internucleotidic linkages. In some embodiments, CpG oligonucleotides comprising one or more CpG region motifs are capable of agonizing an immune response. In some embodiments, CpG oligonucleotides comprising one or more CpG region motifs are antagonistic. Methods for making and using chirally controlled CpG oligonucleotide compositions are also described. In some embodiments, no immune modulation is desired, and the present disclosure provides methods of identifying chirally controlled oligonucleotide compositions which have decreased immune modulation.

  本公开涉及这样一种认识，即 CpG 寡核苷酸介导的免疫反应可受硫代磷酸酯等修饰的核苷酸间连接的立体化学的影响。在一些实施方案中，本公开涉及手性控制的 CpG 寡核苷酸组合物，该组合物包含CpG 寡核苷酸，该CpG 寡核苷酸包含多个修饰的核苷酸间连接，如硫代磷酸酯连接，其中寡核苷酸包含一个或多个 CpG 区域基序，该 CpG 区域基序具有手性核苷酸间连接的确定立体化学模式。在一些实施方案中，包含一个或多个 CpG 区域基团的 CpG 寡核苷酸能够激动免疫反应。在某些实施方案中，包含一个或多个 CpG 区域基团的 CpG 寡核苷酸具有拮抗作用。还描述了制作和使用啁啾控制 CpG 寡核苷酸组合物的方法。在某些实施方案中，不需要免疫调节，本公开提供了确定免疫调节性降低的手性控制寡核苷酸组合物的方法。
• EACHERN, ANITA MAC;SOUCY, CHANTAL;LEITCH, LEONARD C.;ARNASON, JOHN T.;MOR+, TETRAHEDRON, 44,(1988) N 9, 2403-2412
  作者：EACHERN, ANITA MAC、SOUCY, CHANTAL、LEITCH, LEONARD C.、ARNASON, JOHN T.、MOR+

  DOI：——

  日期：——
• METAL-BASED COORDINATION COMPLEXES AS PHOTODYNAMIC COMPOUNDS AND THEIR USE
  申请人：MCFARLAND Sherri Ann

  公开号：US20160039854A1

  公开（公告）日：2016-02-11

  Compositions of the invention include metal-based coordination complexes, which are preferably tunable photodynamic compounds. The compositions and complexes are useful as therapeutic agents and as in vivo diagnostic agents for treating or preventing diseases including those that involve hyperproliferating cells in their etiology, such as cancer. Compositions and complexes of the invention are further capable of destroying microbial cells, such as bacteria, fungi, and protozoa, and destroying viruses. The compositions and complexes are also capable of modulating cell function in other ways.