2-(benzyloxy)-4,6-dimethoxyphenol | 1357024-84-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-(benzyloxy)-4,6-dimethoxyphenol
• CAS: 1357024-84-0
• 化学式: C₁₅H₁₆O₄
• 分子量: 260.29
• InChiKey: BXXJSGCFJOIDRU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.99
• 重原子数：
  19.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  47.92
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  2-(benzyloxy)-4,6-dimethoxyphenol 在 potassium carbonate 、 三氯氧磷 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 9.5h， 生成 4-benzyloxy-2,3,6-trimethoxybenzaldehyde
  参考文献：
  名称：

  A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions

  摘要：

  In the present report, a concise synthesis of viscolin (1) has been achieved. The anti-inflammatory effect of viscolin was investigated in vitro and in vivo. Viscolin blocked the expression of iNOS and COX-2, and it also inhibited the ERIC for the activation of NF-kappa B in LPS-stimulated RAW 264.7 macrophages. Western blotting and immunohistochemical analysis revealed that viscolin decreased Carr-induced iNOS and COX-2 expressions. These results could help to deduce the anti-inflammatory mechanisms. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.12.008
• 作为产物：
  描述：

  2,4,6-三甲氧基苯甲醛 在 三溴化硼 、 potassium carbonate 、 间氯过氧苯甲酸 、 sodium hydroxide 作用下， 以 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 15.0h， 生成 2-(benzyloxy)-4,6-dimethoxyphenol
  参考文献：
  名称：

  A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions

  摘要：

  In the present report, a concise synthesis of viscolin (1) has been achieved. The anti-inflammatory effect of viscolin was investigated in vitro and in vivo. Viscolin blocked the expression of iNOS and COX-2, and it also inhibited the ERIC for the activation of NF-kappa B in LPS-stimulated RAW 264.7 macrophages. Western blotting and immunohistochemical analysis revealed that viscolin decreased Carr-induced iNOS and COX-2 expressions. These results could help to deduce the anti-inflammatory mechanisms. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.12.008

文献信息

• A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions
  作者：Guan-Jhong Huang、M. Vijaya Bhaskar Reddy、Ping-Chung Kuo、Chieh-Hung Huang、Hung-Cheng Shih、E.-Jian Lee、Mei-Lin Yang、Yann-Lii Leu、Tian-Shung Wu

  DOI：10.1016/j.ejmech.2011.12.008

  日期：2012.2

  In the present report, a concise synthesis of viscolin (1) has been achieved. The anti-inflammatory effect of viscolin was investigated in vitro and in vivo. Viscolin blocked the expression of iNOS and COX-2, and it also inhibited the ERIC for the activation of NF-kappa B in LPS-stimulated RAW 264.7 macrophages. Western blotting and immunohistochemical analysis revealed that viscolin decreased Carr-induced iNOS and COX-2 expressions. These results could help to deduce the anti-inflammatory mechanisms. (C) 2011 Elsevier Masson SAS. All rights reserved.