N-(1-Cyclohexen-1-yl)benzolamin | 10592-26-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(1-Cyclohexen-1-yl)benzolamin
• 英文别名: cyclohex-1-enylphenylamine；Cyclohex-1-enylanilin；Anilino-cyclohexen；Benzenamine, N-1-cyclohexen-1-yl-；N-(cyclohexen-1-yl)aniline
• CAS: 10592-26-4
• 化学式: C₁₂H₁₅N
• 分子量: 173.258
• InChiKey: NMHAAZGGTJQEFL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-(1-Cyclohexen-1-yl)benzolamin 以 四氯化碳 为溶剂， 反应 168.0h， 生成 N-苯基环己亚胺
  参考文献：
  名称：

  Kayukova, L. A.; Erzhanov, K. B.; Umarova, Z. N., Journal of Organic Chemistry USSR (English Translation), 1988, vol. 24, p. 111 - 119

  摘要：

  DOI：
• 作为产物：
  描述：

  N-(1-cyclohexen-1-yl)-N-(trimethylsilyl)aniline 在 盐酸 、 水 作用下， 以 氘代二甲亚砜 为溶剂， 生成 N-(1-Cyclohexen-1-yl)benzolamin
  参考文献：
  名称：

  Comparison of the tautomerization and hydrolysis of some secondary and tertiary enamines

  摘要：

  DOI：

  10.1021/jo00295a017

文献信息

• Synthesis of 3-Sulfonylamino Quinolines from 1-(2-Aminophenyl) Propargyl Alcohols through a Ag(I)-Catalyzed Hydroamination, (2 + 3) Cycloaddition, and an Unusual Strain-Driven Ring Expansion
  作者：Yalla Kiran Kumar、Gadi Ranjith Kumar、Thota Jagadeshwar Reddy、Balasubramanian Sridhar、Maddi Sridhar Reddy

  DOI：10.1021/acs.orglett.5b00832

  日期：2015.5.1

  We describe herein a silver-catalyzed conversion of 1-(2-aminophenyl)-propargyl alcohols to 4-substituted 3-tosylaminoquinolines using TsN3 as an amino surrogate. Controlled reactions reveal the pathway consisting of Ag(I)-catalyzed 5-exo-dig cyclization, catalyst-free (2 + 3) cycloaddition, and ring-expansive rearrangement via nitrogen expulsion. As a support study, we show that the cyclic enamines

  我们在本文中描述了使用TsN 3作为氨基替代物将银催化的1-（2-氨基苯基）-炔丙基醇向4-取代的3-甲苯磺酰基氨基喹啉的银催化转化。受控的反应揭示了由Ag（I）催化的5- exo - dig环化，无催化剂的（2 + 3）环加成和通过氮驱出的环膨胀重排组成的途径。作为一项支持研究，我们证明了在类似条件下的环状烯胺会通过C-C键迁移而产生am。
• [EN] RUTHENIUM-CATALYZED HYDROAMINATION OF OLEFINS<br/>[FR] HYDROAMINATION D'OLEFINES CATALYSEE PAR RUTHENIUM
  申请人：UNIV YALE

  公开号：WO2005077885A1

  公开（公告）日：2005-08-25

  Applicants have unexpectedly discovered that catalysts made from a ruthenium catalyst precursor or preformed ruthenium catalysts as otherwise described in the present specification are capable of effecting the addition of a N-H bond across an olefin C=C (olefinic) bond of a substrate with a high degree of regioselectivity and enantioselectivity in high yield. These addition reactions proceed in an anti-Markovnikov or Markovnikov fashion depending upon the catalyst precursor used to generate the ruthenium catalyst which actually participates in the addition reaction. The present invention relates to methods of adding N-H bonds across an olefinic bond in a substrate, using a ruthenium catalyst precursor or catalyst I comprising a compound according to the general structure I: Formula (I) where Ru is a ruthenium atom; L1 represents one or more coordinated ancillary ligands, which may be all the same ligand or which may be a combination of different ligands, each of which may be neutral or formally charged, and each of which may be monodentate and coordinated to ruthenium through a single atom or which may be linked or chelated and bound through more than one atom; L2 represents one or more formally charged ligands which are the same or different and which are optionally susceptible to removal with a strong acid; and x is 0-6, preferably 1, y is 0-6, preferably 2 and n is 1-4, preferably 1.

  申请人意外地发现，根据本说明书描述的钌催化剂前体或预先形成的钌催化剂能够以高产率实现对底物的烯烃C=C（烯烃）键进行N-H键的加成反应，并具有很高的区域选择性和对映选择性。这些加成反应可以以反Markovnikov或Markovnikov方式进行，具体取决于用于生成实际参与加成反应的钌催化剂的催化剂前体。本发明涉及一种使用钌催化剂前体或催化剂I的方法，在底物的烯烃键上添加N-H键，催化剂I包括符合一般结构I的化合物：公式（I），其中Ru是钌原子；L1代表一个或多个配位辅助配体，可以是全部相同的配体，也可以是不同配体的组合，每个配体可以是中性的或正式带电的，每个配体可以是一齿的，并通过单个原子与钌配位，也可以是连接或螯合并通过多于一个原子结合；L2代表一个或多个正式带电的配体，可以是相同的或不同的，并且可以通过强酸去除；x为0-6，优选为1，y为0-6，优选为2，n为1-4，优选为1。
• Selected pyrazolyl derivatives
  申请人：Monsanto Company

  公开号：US05498624A1

  公开（公告）日：1996-03-12

  Novel azolyl derivatives, ie 2'-(substituted)cycloalkyl carboxanilides, useful as fungicides, methods of using said compounds and mixtures containing them.

  小说性的氮杂环衍生物，即2'-(取代)环烷基羧酰苯胺，可用作杀真菌剂，使用上述化合物的方法以及包含它们的混合物。
• Process for disproportionating silanes
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0206621A1

  公开（公告）日：1986-12-30

  A process for disproportionating silanes, which comprises contacting a silane having at least one Si-H bond represented by the general formula wherein R represents an alkyl or aryl group, X represents a halogen atom or an alkoxy group, ℓis 0, 1 or 2, and m is 1, 2 or 3 and ℓ+m is 1, 2 or 3, and when fis 2, R's may be identical or different, and when ℓ+m is 1 or 2, X's may be identical or different, with a reaction product of a strong acid-type cation exchange resin with an amine.

  一种歧化硅烷的工艺，其包括与具有至少一个 Si-H 键的硅烷接触，该硅烷由通式表示 其中 R 代表烷基或芳基，X 代表卤素原子或烷氧基，ℓ 为 0、1 或 2，m 为 1、2 或 3，ℓ+m 为 1、2 或 3，当 f 为 2 时，R 可以相同或不同，当 ℓ+m 为 1 或 2 时，X 可以相同或不同。
• Enaminones as potential prodrugs of primary and secondary amines
  申请人：Merck & Co., Inc.

  公开号：EP0214009A2

  公开（公告）日：1987-03-11

  Novel enzymatically labile enaminones useful as potential prodrugs of primary and secondary amines are disclosed. Also, disclosed herein are compositions comprising said amines and methods of administering said composition to warm-blooded animals.

  本发明公开了可作为伯胺和仲胺潜在原药的新型酶标记烯酮。此外，本文还公开了包含所述胺的组合物以及将所述组合物用于温血动物的方法。