N-(isonicotinoyl)-N'-nicotinoylhydrazine | 15033-22-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-(isonicotinoyl)-N'-nicotinoylhydrazine
• 英文别名: N-isonicotinoyl-N'-nicotinoyl hydrazine；N-Isonicotinoyl-N'-nicotinoyl-hydrazin；N-Isonicotinoyl-N'-nicotinoyl-hydrazin；N'-(pyridine-4-carbonyl)pyridine-3-carbohydrazide
• CAS: 15033-22-4
• 化学式: C₁₂H₁₀N₄O₂
• mdl: MFCD00534273
• 分子量: 242.237
• InChiKey: ISNJPMYTXCCOGZ-UHFFFAOYSA-N

物化性质

• 熔点：
  225-226 °C
• 沸点：
  551.5±38.0 °C(Predicted)
• 密度：
  1.313±0.06 g/cm3(Predicted)
• 溶解度：
  28.3 [ug/mL]

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  84
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(isonicotinoyl)-N'-nicotinoylhydrazine 、 potassium iodide 、 silver(I) iodide 以 四氢呋喃 、 甲醇 、 水 为溶剂， 以20%的产率得到[(AgI(N-(isonicotinoyl)-N'-nicotinoylhydrazine))6(KI)]
  参考文献：
  名称：

  Synthesis, Structure, and Large Optical Limiting Effect of the First Coordination Polymeric Cluster Based on an {I@[AgI(inh)]₆} Hexagram Block

  摘要：

  In this paper, treatment of N-(isonicotinoyl)-N'-nicotinoylhydrazine (inh) and Agl with excess KI afforded a unique coordination polymeric cluster {[Agl(inh)](6)(KI)}(n) (1) with the hexagram cluster units centered by mu(6)-l. In the polymer these hexagram units are parallel to the ab plane and are linked by separated K+ centers through inh. Polymer 1 represents the first example of coinstantaneous cation-anion-induced supramolecular self-assembly with nanoscale inner cavities. The polymer's third-order nonlinear optical (NLO) properties were determined by the Z-scan technique in DMF solution. The results show that the polymer has strong third-order optical nonlinearities. The nonlinear absorptive index a(2) and refractive index n(2) are calculated to be 1.044 x 10(-9) mW(-1) and 2.827 x 10(-11) esu, respectively. The values are comparable to those of the reported cluster polymers. The optical limiting experiments show that the present cluster exhibits a large optical limiting capacity. The value of the limiting threshold was measured as 0.53 J cm(-2) from the optical limiting experimental data. This value is three times better than 1.6 J cm(-2) of C-60. This paper also gives a summary and comparison on the optical limiting properties of oligomeric and polymeric clusters.

  DOI：

  10.1021/ic0487023
• 作为产物：
  描述：

  烟酸 在 氯化亚砜 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 生成 N-(isonicotinoyl)-N'-nicotinoylhydrazine
  参考文献：
  名称：

  Synthesis, Antimycobacterial, Antiviral, Antimicrobial Activity and QSAR Studies of N2-acyl isonicotinic Acid Hydrazide Derivatives

  摘要：

  合成了一系列N2-酰基异烟酸肼（1-17），并对其在体外对抗结核分枝杆菌的活性进行了测试，结果表明，化合物异烟酸N'-十四酰肼（12）的活性优于参考化合物异烟肼。合成化合物对金黄色葡萄球菌、枯草芽孢杆菌、大肠杆菌、白念珠菌和黑曲霉的抗菌活性结果表明，含有二氯、羟基、三碘和N2-十四酰取代基的化合物是活性最强的。抗病毒活性研究表明，所测试的化合物对DNA或RNA病毒均未表现出活性。多靶点QSAR模型有效地描述了N2-酰基异烟酸肼的抗菌活性。

  DOI：

  10.2174/157340613804488404

文献信息

• Synthetic Tuberculostats. VIII. Acyl Derivatives of Isonicotinyl Hydrazine
  作者：H. Herbert Fox、John T. Gibas

  DOI：10.1021/jo50016a018

  日期：1953.10
• Grillo et al., Anales de la Sociedad de Biologia de Bogota, 1955, vol. 6, p. 234,235
  作者：Grillo et al.

  DOI：——

  日期：——
• Assessing the Potential of Vitamin Drug Conjugate for Its Activity against Infectious Disease
  作者：R. P. Bhole、P. C. Bhondave、R. V. Chikhale

  DOI：10.1134/s1068162024010151

  日期：2024.2
• HEME OXYGENASE INHIBITORS, SCREENING METHODS FOR HEME OXYGENASE INHIBITORS AND METHODS OF USE OF HEME OXYGENASE INHIBITORS FOR ANTIMICROBIAL THERAPY
  申请人：Wilks Angela

  公开号：US20100081661A1

  公开（公告）日：2010-04-01

  Inhibitors of microbial heme oxygenase and their use for treatment of microbial infections and bioremediation. The inhibitors of microbial heme oxygenase are useful against a new class of antimicrobial agents to target infections that are persistently difficult to combat with the current spectrum of antimicrobial agents. Screening methods for selecting inhibitors of microbial heme oxygenase.