吡啶-3-羧酸戊酯 | 49558-04-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 吡啶-3-羧酸戊酯
• 英文名称: nicotinic acid pentyl ester
• 英文别名: Nicotinsaeure-pentylester；Nicotinsaeurepentylester；Nicotinic acid, pentyl ester；pentyl pyridine-3-carboxylate
• CAS: 49558-04-5
• 化学式: C₁₁H₁₅NO₂
• mdl: MFCD00047453
• 分子量: 193.246
• InChiKey: SYIRQWIOOCVBTC-UHFFFAOYSA-N

物化性质

• 溶解度：
  0.00 M
• 保留指数：
  1497

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.454
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  烟酸 在 吡啶 、 氯化亚砜 作用下， 生成 吡啶-3-羧酸戊酯
  参考文献：
  名称：

  Nicotinic Acid. Water-insoluble Esters and Amides

  摘要：

  DOI：

  10.1021/ja01223a028

文献信息

• Nucleotide and oligonucleotide prodrugs
  申请人：Iyer P. Radhakrishnan

  公开号：US20070149462A1

  公开（公告）日：2007-06-28

  The present invention discloses compounds of formula (I): which exhibit antiviral properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of anti-HBV treatment. The invention also relates to methods of treating a HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

  本发明揭示了具有以下式（I）的化合物：这些化合物具有抗病毒性能。本发明还涉及包含上述化合物的药物组合物，用于给需要抗乙型肝炎治疗的受试者使用。该发明还涉及通过给予包含本发明化合物的药物组合物来治疗受试者的HBV感染的方法。
• METHOD FOR PRODUCING CARBOXYLIC ACID AMIDE
  申请人：Tomokawa Junichi

  公开号：US20130123505A1

  公开（公告）日：2013-05-16

  A carboxamide can be produced in a high yield by a method for producing a carboxamide, for example, represented by formula (4): (wherein R 1 and R 3 are as defined below), the method comprising a step of allowing a carboxylic acid ester represented by formula (1): (wherein R 1 represents an optionally substituented C 1 -C 20 hydrocarbon group or an optionally substituented C 3 -C 20 heterocyclic group, and R 2 represents an optionally substituented C 1 -C 20 hydrocarbon group), an amine represented by formula (2): R 3 —NH 2 (2) (wherein R 3 represents a hydrogen atom or an optionally substituented C 1 -C 20 hydrocarbon group), and a formamide compound represented by formula (3): (wherein R 3 is as defined above) to react in the presence of a metal alkoxide.

  通过一种生产羧酰胺的方法可以高产率生产羧酰胺，例如，如公式（4）所示的方法：（其中R1和R3如下定义），该方法包括允许由公式（1）表示的羧酸酯（其中R1表示可选取代的C1-C20烃基或可选取代的C3-C20杂环基，R2表示可选取代的C1-C20烃基），由公式（2）表示的胺：R3—NH2（2）（其中R3表示氢原子或可选取代的C1-C20烃基），以及由公式（3）表示的甲酰胺化合物（其中R3如上所定义）在金属烷氧化物存在下反应的步骤。
• Cosmetic composition
  申请人：UNILEVER PLC

  公开号：EP0489581A2

  公开（公告）日：1992-06-10

  Compositions containing an ester of nicotinic acid and a cosmetically acceptable surfactant are provided. These compositions, when applied topically to the human body produce a response such as a sensory or therapeutic response, for example a tingling or warming sensation or an increase in blood flow, which persists after the composition is rinsed from the body. The compositions are particularly suitable for application to the hair and/or scalp where they may encourage hair growth. Compositions for application to the hair and/or scalp preferably additionally comprise hair benefit agents such as hair growth promoters.

  提供含有烟酸酯和化妆品可接受的表面活性剂的组合物。这些组合物在局部涂抹到人体时会产生一种感官或治疗反应，例如刺痛或温热感觉，或者增加血液流动，这种反应在组合物被冲洗后仍然持续。这些组合物特别适用于涂抹到头发和/或头皮，可以促进头发生长。用于涂抹到头发和/或头皮的组合物最好还包括头发益处剂，如促进头发生长的剂。
• NUCLEOTIDE AND OLIGONUCLEOTIDE PRODRUGS
  申请人：Spring Bank Pharmaceuticals, Inc.

  公开号：US20140323554A1

  公开（公告）日：2014-10-30

  The present invention discloses compounds of formula (I): which exhibit antiviral properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of anti-HBV treatment. The invention also relates to methods of treating a HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

  本发明公开了式（I）化合物，其具有抗病毒性质。本发明还涉及包含上述化合物的药物组合物，用于治疗需要抗乙型肝炎治疗的受体。本发明还涉及通过给予包含本发明化合物的药物组合物来治疗受体的乙型肝炎感染的方法。
• Process for preparing polyolefins
  申请人：Nippon Petrochemicals Co., Ltd.

  公开号：EP0267794A2

  公开（公告）日：1988-05-18

  A process for preparing a polyolefin by homopolymerizing or copolymerizing an olefin or olefins using a catalyst comprising a solid catalyst component and an organometallic compound, said solid catalyst component being obtained by contacting at least a titanium compound and/or a vanadium compound with a solid material (a), said solid material (a) being obtained by contacting the following components (1), (2) and (3) with one another: (1) a silicon oxide and/or an aluminum oxide, (2) a magnesium halide, and (3) an organometallic compound.

  一种使用由固体催化剂组分和有机金属化合物组成的催化剂，通过均聚或共聚一种或多种烯烃制备聚烯烃的工艺，所述固体催化剂组分通过将至少一种钛化合物和/或钒化合物与固体材料（a）接触而获得，所述固体材料（a）通过将以下组分（1）、（2）和（3）相互接触而获得：（1）氧化硅和/或氧化铝，（2）卤化镁，和（3）有机金属化合物。