吡啶-3-羧酸癸酯 | 5338-17-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 吡啶-3-羧酸癸酯
• 英文名称: nicotinic acid decyl ester
• 英文别名: Nicotinsaeure-decylester；Nicotinsaeuredecylester；Nicotinic acid, decyl ester；decyl pyridine-3-carboxylate
• CAS: 5338-17-0
• 化学式: C₁₆H₂₅NO₂
• 分子量: 263.38
• InChiKey: OVSJCKDIBDNMMK-UHFFFAOYSA-N

物化性质

• 溶解度：
  6.46e-04 M
• 保留指数：
  1920

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  19
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2933399090

反应信息

• 作为产物：
  描述：

  癸醇 、 氯化烟碱盐酸盐 在 吡啶 作用下， 生成 吡啶-3-羧酸癸酯
  参考文献：
  名称：

  Water-Insoluble Forms of Thiamine and Niacin

  摘要：

  DOI：

  10.1021/ja01206a008

文献信息

• Cosmetic composition
  申请人：UNILEVER PLC

  公开号：EP0489581A2

  公开（公告）日：1992-06-10

  Compositions containing an ester of nicotinic acid and a cosmetically acceptable surfactant are provided. These compositions, when applied topically to the human body produce a response such as a sensory or therapeutic response, for example a tingling or warming sensation or an increase in blood flow, which persists after the composition is rinsed from the body. The compositions are particularly suitable for application to the hair and/or scalp where they may encourage hair growth. Compositions for application to the hair and/or scalp preferably additionally comprise hair benefit agents such as hair growth promoters.

  提供含有烟酸酯和化妆品可接受的表面活性剂的组合物。这些组合物在局部涂抹到人体时会产生一种感官或治疗反应，例如刺痛或温热感觉，或者增加血液流动，这种反应在组合物被冲洗后仍然持续。这些组合物特别适用于涂抹到头发和/或头皮，可以促进头发生长。用于涂抹到头发和/或头皮的组合物最好还包括头发益处剂，如促进头发生长的剂。
• Niacinamide, niacin, and niacin esters based delivery systems for treating topical disorders of skin and skin aging
  申请人：——

  公开号：US20040081672A1

  公开（公告）日：2004-04-29

  The present invention relates to application of niacinamide, niacin, and niacin esters (nicotinic acid esters) derivatives of skin beneficial organic acids (henceforth called “derivatives”) for the synergistic treatment or prevention of topical disorders of skin such as acne, rosacea, skin wrinkles, age-spots, canker sores, striae distensae (stretch marks), pimples, and skin redness. These “derivatives” are made by a very simple in-situ method. These “derivatives” provide enhanced bioavailability of both ingredients that are combined to form such derivatives. The “derivatives” of present invention can be formulated in a wide variety of delivery systems including traditional water and oil emulsions, suspensions, colloids, solutions, or anhydrous systems. Niacin and certain niacin ester derivatives prepared by the in-situ method are free of flushing effect (a warm feeling in the skin usually associated with redness and itching) normally experienced with niacin and certain niacin esters themselves.
• Water-Insoluble Forms of Thiamine and Niacin
  作者：Wolfgang Huber、Werner Boehme、S. C. Laskowski

  DOI：10.1021/ja01206a008

  日期：1946.2