2-isocyanato-3-(4-isocyanatophenyl)propionic acid octadecyl ester | 1393525-33-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-isocyanato-3-(4-isocyanatophenyl)propionic acid octadecyl ester
• 英文别名: 2-Isocyanato-3-(4-isocyanato-phenyl)-propionic acid Stearyl ester；2-Isocyanato-3-(4-Isocyanato-phenyl)-propionic acid octadecyl ester；octadecyl 2-isocyanato-3-(4-isocyanatophenyl)propanoate
• CAS: 1393525-33-1
• 化学式: C₂₉H₄₄N₂O₄
• 分子量: 484.679
• InChiKey: IXBNXMZFFPURRU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.7
• 重原子数：
  35
• 可旋转键数：
  23
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  85.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-硝基-DL-苯丙氨酸 在 palladium-carbon sodium hydroxide 、 potassium carbonate 作用下， 以 1,4-二氧六环 、 正己烷 、 水 、 乙酸乙酯 、 甲苯 为溶剂， 生成 2-isocyanato-3-(4-isocyanatophenyl)propionic acid octadecyl ester
  参考文献：
  名称：

  AMINO ACID DERIVATIVES AND ABSORABLE POLYMERS THEREFROM

  摘要：

  本发明涉及一种新类水解性氨基酸衍生物和可吸收聚酯酰胺、聚酰胺、聚环氧化物、聚脲和由此制备的聚氨酯。所得的可吸收聚合物可用于药物输送、组织工程、组织粘合剂、粘附预防、骨蜡配方、医疗器械涂层、支架、支架涂层、高度多孔泡沫、网状泡沫、伤口护理、心血管应用、骨科器械、表面改性剂和其他可植入医疗器械。此外，这些可吸收聚合物应具有受控降解特性。

  公开号：

  US20120208896A1

文献信息

• AMINO ACID DERIVATIVES AND ABSORABLE POLYMERS THEREFROM
  申请人：Bezwada Rao S.

  公开号：US20120208896A1

  公开（公告）日：2012-08-16

  The present invention relates to the discovery of new class of hydrolysable amino acid derivatives and absorbable polyester amides, polyamides, polyepoxides, polyureas and polyurethanes prepared therefrom. The resultant absorbable polymers are useful for drug delivery, tissue engineering, tissue adhesives, adhesion prevention, bone wax formulations, medical device coatings, stents, stent coatings, highly porous foams, reticulated foams, wound care, cardiovascular applications, orthopedic devices, surface modifying agents and other implantable medical devices. In addition, these absorbable polymers should have a controlled degradation profile.

  本发明涉及一种新类水解性氨基酸衍生物和可吸收聚酯酰胺、聚酰胺、聚环氧化物、聚脲和由此制备的聚氨酯。所得的可吸收聚合物可用于药物输送、组织工程、组织粘合剂、粘附预防、骨蜡配方、医疗器械涂层、支架、支架涂层、高度多孔泡沫、网状泡沫、伤口护理、心血管应用、骨科器械、表面改性剂和其他可植入医疗器械。此外，这些可吸收聚合物应具有受控降解特性。
• Amino acid derivatives and absorbable polymers therefrom
  申请人：Bezwada Rao S.

  公开号：US08461372B2

  公开（公告）日：2013-06-11

  The present invention relates to the discovery of new class of hydrolysable amino acid derivatives and absorbable polyester amides, polyamides, polyepoxides, polyureas and polyurethanes prepared therefrom. The resultant absorbable polymers are useful for drug delivery, tissue engineering, tissue adhesives, adhesion prevention, bone wax formulations, medical device coatings, stents, stent coatings, highly porous foams, reticulated foams, wound care, cardiovascular applications, orthopedic devices, surface modifying agents and other implantable medical devices. In addition, these absorbable polymers should have a controlled degradation profile.

  本发明涉及新型可水解氨基酸衍生物和可吸收的聚酰胺、聚氨酯、聚环氧化物、聚脲和由此制备的聚氨酯，这些可吸收的聚合物可用于药物传递、组织工程、组织粘合剂、附着预防、骨蜡配方、医疗器械涂层、支架、支架涂层、高度多孔泡沫、网状泡沫、伤口护理、心血管应用、骨科设备、表面改性剂和其他可植入医疗器械。此外，这些可吸收的聚合物应具有可控的降解特性。
• Multi-putty adhesive and cement compositions for tissue hemostasis, repair and reconstruction
  申请人：Abyrx, Inc.

  公开号：US11116866B2

  公开（公告）日：2021-09-14

  The disclosure relates to polyurethane and polyureaurethane based putty compositions which harden into a fully cured solid form at room temperature and body temperature and are suitable for use as a bone cement, bone substitute, hard tissue adhesive, or bone hemostatic agent.

  本公开涉及以聚氨酯和聚脲烷为基础的腻子组合物，这些组合物在室温和体温下硬化成完全固化的固体形式，适合用作骨水泥、骨替代物、硬组织粘合剂或骨止血剂。
• Absorbable Multi-Putty Bone Cements and Hemostatic Compositions and Methods of Use
  申请人：Abyrx Inc.

  公开号：US20160250374A1

  公开（公告）日：2016-09-01

  The disclosure relates to polyurethane and polyureaurethane based putty compositions which harden into a fully cured solid form at room temperature and body temperature and are suitable for use as a bone cement, bone substitute, hard tissue adhesive, or bone hemostatic agent.
• MULTI-PUTTY ADHESIVE AND CEMENT COMPOSITIONS FOR TISSUE HEMOSTASIS, REPAIR AND RECONSTRUCTION
  申请人：Abyrx, Inc.

  公开号：US20190099514A1

  公开（公告）日：2019-04-04

  The disclosure relates to polyurethane and polyureaurethane based putty compositions which harden into a fully cured solid form at room temperature and body temperature and are suitable for use as a bone cement, bone substitute, hard tissue adhesive, or bone hemostatic agent.