2-[[2-[(4-Chlorophenyl)methoxy]phenyl]methylideneamino]guanidine | 196792-38-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-[[2-[(4-Chlorophenyl)methoxy]phenyl]methylideneamino]guanidine
• CAS: 196792-38-8
• 化学式: C₁₅H₁₅ClN₄O
• 分子量: 302.763
• InChiKey: QLZIJPLTRJOVDN-UHFFFAOYSA-N

物化性质

• 沸点：
  467.7±55.0 °C(Predicted)
• 密度：
  1.28±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  86
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-[(4-氯苄基)氧基]苯甲醛 、 肼甲酰亚胺酰胺一氯化氢 在 盐酸 作用下， 以 乙醇 为溶剂， 生成 2-[[2-[(4-Chlorophenyl)methoxy]phenyl]methylideneamino]guanidine
  参考文献：
  名称：

  New furin inhibitors based on weakly basic amidinohydrazones

  摘要：

  A novel series of amidinohydrazone-derived furin inhibitors was prepared; the most potent compounds 17 and 21 inhibit furin with K-i values of 0.46 and 0.59 mu M, respectively. In contrast to inhibitor 17, which still contains a guanidino residue, compound 21 possesses only weakly basic amidinohydrazone groups. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.11.092

文献信息

• New furin inhibitors based on weakly basic amidinohydrazones
  作者：Frank Sielaff、Manuel E. Than、Dorian Bevec、Iris Lindberg、Torsten Steinmetzer

  DOI：10.1016/j.bmcl.2010.11.092

  日期：2011.1

  A novel series of amidinohydrazone-derived furin inhibitors was prepared; the most potent compounds 17 and 21 inhibit furin with K-i values of 0.46 and 0.59 mu M, respectively. In contrast to inhibitor 17, which still contains a guanidino residue, compound 21 possesses only weakly basic amidinohydrazone groups. (C) 2010 Elsevier Ltd. All rights reserved.