Undec-4-insaeure | 54299-11-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Undec-4-insaeure
• 英文别名: 4-Undecinsaeure；4-Undecynoic acid；undec-4-ynoic acid
• CAS: 54299-11-5
• 化学式: C₁₁H₁₈O₂
• 分子量: 182.263
• InChiKey: RICXZQBDWBCFKY-UHFFFAOYSA-N

物化性质

• 熔点：
  34.04°C (estimate)
• 沸点：
  341.17°C (rough estimate)
• 密度：
  0.9898 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Undec-4-insaeure 在 双(乙腈)氯化钯(II) 水 作用下， 以 乙醚 、 乙腈 为溶剂， 反应 1.0h， 生成 dodecane-2,5-dione
  参考文献：
  名称：

  Synthesis of substituted furans by palladium-catalyzed cyclization of acetylenic ketones

  摘要：

  Palladium-catalyzed cyclization of beta,gamma-acetylenic ketones gives furans by intramolecular oxypalladation and subsequent protodemetalation. 3-Allylfurans were exclusively obtained by trapping the intermediate 3-furyl-palladium species with allyl halides in the presence of 2,2-dimethyloxirane as a proton scavenger.

  DOI：

  10.1021/jo00020a024

文献信息

• Relay Catalytic Branching Cascade: A Technique to Access Diverse Molecular Scaffolds
  作者：Nitin T. Patil、Valmik S. Shinde、Balasubramanian Sridhar

  DOI：10.1002/anie.201208738

  日期：2013.2.18

  Skeletal diversity: The reactions of alkynoic acids (A, common type of substrates) with various scaffold‐building agents (B) under gold catalysis produce a series of multifunctional polyheterocyclic structures (see scheme). The approach enables the preparation of compound libraries with high skeletal diversity.

  骨骼多样性：在金催化下，炔酸（A，常见的底物类型）与各种支架构建剂（B）的反应产生了一系列多功能的多杂环结构（参见方案）。该方法能够制备具有高骨架多样性的化合物文库。
• Palladium-catalyzed intramolecular addition of amines to acetylenes. Synthesis of cyclic imines
  作者：Yukitoshi Fukuda、Seijiro Matsubara、Kiitiro Utimoto

  DOI：10.1021/jo00020a023

  日期：1991.9

  Intramolecular aminopalladation of alkynylamines gave intermediary alkenylpalladium compounds that hydrolyzed and isomerized to thermodynamically stable cyclic imines. Treatment of 3-alkynylamines with a catalytic amount of PdCl2(MeCN)2 gave exclusively 1-pyrrolines in good yields; 5-alkynylamines afforded 2,3,4,5-tetrahydropyridines selectively. Treatment of 4-alkynylamines with Pd(II) afforded mixtures of both 5- and 6-membered cyclic imines. Applications to the synthesis of some naturally occurring alkaloids are also described.
• NEUROTROPHIC AND ANTIPROLIFERATIVE COMPOUNDS
  申请人：AMERICAN BIOGENETIC SCIENCES, INC.

  公开号：EP0778820A1

  公开（公告）日：1997-06-18
• COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING MUSCULAR DISORDERS AND DYSTROPHIES, STEROID SIDE EFFECTS, AND INFLAMMATION
  申请人：Children's National Medical Center

  公开号：US20210198669A1

  公开（公告）日：2021-07-01

  The present disclosure relates to compositions comprising an antisense RNA sequence comprising a region of complementarity that is substantially complementary to an miRNA. Pharmaceutical compositions comprising the antisense RNA molecule, optionally further comprising an anti-inflammatory corticosteroid are also disclosed. Methods of treating or preventing inflammation, a steroid side effect, or a muscle disease using the one or the pharmaceutical compositions are also disclosed.
• [EN] NEUROTROPHIC AND ANTIPROLIFERATIVE COMPOUNDS<br/>[FR] COMPOSES NEUROTROPHIQUES ET ANTIPROLIFERATIFS
  申请人：——

  公开号：WO1996006821A1

  公开（公告）日：1996-03-07

  [EN] Neurotrophic and antiproliferative compounds related to the antiepileptic drug valproate of general formula (I), wherein R<1> is -CCH, -CH=CH2 or -CH2-CH3, R<2> is a saturated, unsaturated, branched or unbranched C1-C30 alkyl group which is optionally substituted with a C3-C9 aliphatic or aromatic cyclohydrocarbon,or heterocyclic group. M is a hydrogen or a metal atom. Formula (I) is not 2-n-propyl-4-pentynoic acid (4-yn-VPA) or 2-n-propyl-4-pentenoic acid (4-en-VPA) and when R<1> is -CH2-CH3, R<2> is C5 to C30. This invention also provides a method of making the compounds of the invention. The compounds are useful for promoting neuronal function as in neurodegenerative disorders and for treating neoplastic disease.
  [FR] L'invention concerne des composés neurotrophiques et antiprolifératifs, se rapportant à l'antiépileptique valproate, de formule générale (I), où R<1> représente -CCH, -CH=CH2 ou -CH2-CH3; R<2> représente un groupe alkyle C1-C30 saturé, non saturé, ramifié ou non; éventuellement substitué par un groupe C3-C9 d'hydrocarbure cyclique aromatique ou aliphatique, ou hétérocyclique; M représente un atome d'hydrogène ou de métal. La formule (I) n'est pas un acide 2-n-propyl-4-pentynoïque (4-yn-VPA) ni un acide 2-n-propyl-4-penténoïque (4-en-VPA) et lorsque R<1> représente -CH2-CH3, R<2> représente C5 à C30. L'invention concerne également un procédé de fabrication desdits composés. Ces composés sont utilisés afin de stimuler la fonction neuronale dans les maladies neurodégénératives et afin de traiter les maladies néoplasiques.