1-methoxy-2,4-diphenylbenzene | 141852-54-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-methoxy-2,4-diphenylbenzene
• 英文别名: 4'-methoxy-meta-terphenyl；4-methoxy-1,3-terphenyl；2,4-Diphenylanisole；methyl-m-terphenyl-4'-yl ether；Methyl-m-terphenyl-4'-yl-aether；4'-Methoxy-m-terphenyl
• CAS: 141852-54-2
• 化学式: C₁₉H₁₆O
• 分子量: 260.335
• InChiKey: NNIJNXPGBQMIPI-UHFFFAOYSA-N

物化性质

• 熔点：
  93-94 °C
• 沸点：
  381.9±21.0 °C(Predicted)
• 密度：
  1.066±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-methoxy-2,4-diphenylbenzene 在 bis-triphenylphosphine-palladium(II) chloride 、 potassium fluoride 、 copper(l) iodide 、 18-冠醚-6 、 溴 、 三乙胺 作用下， 以 乙二醇二甲醚 、 氯仿 为溶剂， 反应 47.0h， 生成 6-ethynyl-1-methoxy-2,4-diphenylbenzene
  参考文献：
  名称：

  Deckert-Gaudig, Tanja; Huenig, Siegfried; Dormann, Elmar, European Journal of Organic Chemistry, 2001, # 8, p. 1563 - 1567

  摘要：

  DOI：
• 作为产物：
  描述：

  苯基-钠 在 alkaline solution 、 苯 作用下， 生成 1-methoxy-2,4-diphenylbenzene
  参考文献：
  名称：

  Luettringhaus; Wagner-v. Saeaef, Justus Liebigs Annalen der Chemie, 1947, vol. 557, p. 25,43

  摘要：

  DOI：

文献信息

• An improved preparation of mesoporous silica-supported Pd as sustainable catalysts for phosphine-free Suzuki-Miyaura and Heck coupling reactions
  作者：Basudeb Basu、Susmita Paul

  DOI：10.1002/aoc.3036

  日期：2013.10

  An improved and eco‐friendly procedure has been developed to generate mesoporous silica‐supported palladium nanoparticles (SiO2@PdNP) that could be used as a sustainable heterogeneous Pd catalyst for phosphine‐free Suzuki–Miyaura and Heck coupling reactions with excellent turnover number and turnover frequency. The presence of Pd on the silica surface was detected by X‐ray diffraction and the structural

  已开发出一种改进的，环保的方法来生成介孔二氧化硅负载的钯纳米粒子（SiO 2 @PdNP），可用作无磷铃木-宫浦和Heck偶联反应的可持续多相Pd催化剂，具有优异的周转率和周转频率。通过X射线衍射检测二氧化硅表面上Pd的存在，并通过透射电子显微镜获得SiO 2 @PdNP的结构形态。非均相催化体系是可回收的，并且在反应之后没有明显地观察到金属的浸出。版权所有©2013 John Wiley＆Sons，Ltd.
• Syntheses of Para-Terphenyl via Reductive Deoxygenation of Quinol Derivatives
  作者：Gary W Morrow、Beverly Schwind

  DOI：10.1080/00397919508010816

  日期：1995.1

  Abstract Syntheses of para-terphenyl via reductive aromatization of 1,4-dioxygenated-1,4-diaryl-2,5-cyclohexadienes are described1

  摘要 描述了通过 1,4-二氧化-1,4-二芳基-2,5-环己二烯的还原芳构化合成对三联苯。
• Solid-supported cross-coupling catalysts derived from homogeneous nickel and palladium coordination complexesElectronic supplementary information (ESI) available: Synthesis of the complexes and crystallographic data for 1 and 2. See http://www.rsc.org/suppdata/dt/b3/b316553c/
  作者：Nam T. S. Phan、David H. Brown、Harry Adams、Sharon E. Spey、Peter Styring

  DOI：10.1039/b316553c

  日期：——

  Solid-supported catalysts derived from homogeneous nickel(II) and palladium(II) non-symmetrical salen-type coordination complexes have been prepared and shown to be effective in the heterogeneous catalysis of carbon–carbon cross-coupling reactions. The nickel catalyst has been used in room-temperature Tamao–Kumada–Corriu reactions and the palladium catalyst in the Heck reaction at elevated temperatures. The complexes were prepared by improved methods and characterised by spectroscopic techniques. Comparisons between the solid-supported catalysts and their homogeneous analogues are reported. The single-crystal structure determination of the nickel and palladium complexes [M(salenac-OH)] [M = Ni, Pd; salenac-OH = 9-(2′,4′-dihydroxyphenyl)-5,8-diaza-4-methylnona-2,4,8-trienato](2−)] is reported.

  基于均相镍(II)和钯(II)非对称salen型配位复合物制备了固体支撑催化剂，并显示其在碳-碳交叉偶联反应的异相催化中具有良好的效果。镍催化剂已用于室温下的Tamao–Kumada–Corriu反应，而钯催化剂则在高温下用于Heck反应。这些复合物通过改进的方法制备，并通过光谱技术进行了表征。还报告了固体支撑催化剂与其均相类似物之间的比较。此外，还报告了镍和钯复合物的单晶结构测定 [M(salenac-OH)] [M = Ni, Pd; salenac-OH = 9-(2′,4′-二羟基苯)-5,8-二氮-4-甲基壬-2,4,8-三烯酸](2−)。
• Selective and general exhaustive cross-coupling of di-chloroarenes with a deficit of nucleophiles mediated by a Pd–NHC complex
  作者：Benjamin J. Groombridge、Stephen M. Goldup、Igor Larrosa

  DOI：10.1039/c4cc08920k

  日期：——

  We report the first example of a general, exhaustive Pd-mediated cross-coupling of polychloroarenes in the presence of a deficit of nucleophiles, mediated by the highly active PEPPSI-IPent catalyst.

  我们报告了在核苷酸亏缺的情况下，通过高活性的PEPPSI-IPent催化剂介导的Pd介导的多氯芳烃的普遍、全面的交叉偶联的首个示例。
• [EN] 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS<br/>[FR] COMPOSES 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE POUR LE TRAITEMENT DE LA TUBERCULOSE
  申请人：OTSUKA PHARMA CO LTD

  公开号：WO2005042542A1

  公开（公告）日：2005-05-12

  The present invention provides a 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound represented by the following general formula: (1)in the above formula (1), R1 represents a hydrogen atom or C1-C6 alkyl group, n represents an integer of 0 to 6, R1 and -(CH2)nR2 may form a spiro ring represented by the formula (30) below, together with the adjacent carbon atom (in the formula below, RRR represents a piperidyl group which may have substituents on the piperidine ring), (30)and R2 represents a benzothiazolyloxy group, quinolyloxy group, pyridyloxy group or the like. The present compound has an excellent bactericidal action against Mycobacterium tuberculosis, multi-drug-resistant Mycobacterium tuberculosis, and atypical acid-fast bacteria.

  本发明提供了一种由以下一般式表示的2,3-二氢-6-硝基咪唑[2,1-b]噁唑化合物：(1)在上述式(1)中，R1代表氢原子或C1-C6烷基，n代表0至6的整数，R1和-(CH2)nR2可以与下面的式(30)一起形成一个螺环，与相邻的碳原子一起（在下面的式中，RRR代表可能在哌啶环上具有取代基的哌啶基），(30)和R2代表苯并噻唑氧基、喹啉氧基、吡啶氧基或类似物。该化合物对结核分枝杆菌、多药耐药结核分枝杆菌和非典型耐酸细菌具有出色的杀菌作用。