<1-Phenyl-ethyl>-N-methyl-hydroxylamin | 19957-58-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: <1-Phenyl-ethyl>-N-methyl-hydroxylamin
• 英文别名: (1-Phenyl-ethyl)-N-methyl-hydroxylamin；Hydroxylamine, methyl-(1-phenylethyl)-；N-methyl-N-(1-phenylethyl)hydroxylamine
• CAS: 19957-58-5
• 化学式: C₉H₁₃NO
• 分子量: 151.208
• InChiKey: ILJJPSBIKXXLRQ-UHFFFAOYSA-N

物化性质

• 沸点：
  249.2±19.0 °C(Predicted)
• 密度：
  1.048±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  <1-Phenyl-ethyl>-N-methyl-hydroxylamin 在 二硫化碳 作用下， 以 乙腈 为溶剂， 反应 20.0h， 以87%的产率得到N-methyl-N-(1-phenylethyl)amine
  参考文献：
  名称：

  Deoxygenation of N,N-disubstituted hydroxylamines by carbon disulfide

  摘要：

  Hindered N,N-dialkylhydroxylamines react rapidly with CS2 to give the corresponding 2-degrees-amines.

  DOI：

  10.1016/s0040-4039(00)91706-4
• 作为产物：
  描述：

  (R)-N-(1-phenylethyl)methanimine oxide 在 sodium tetrahydroborate 作用下， 生成 <1-Phenyl-ethyl>-N-methyl-hydroxylamin
  参考文献：
  名称：

  Deoxygenation of N,N-disubstituted hydroxylamines by carbon disulfide

  摘要：

  Hindered N,N-dialkylhydroxylamines react rapidly with CS2 to give the corresponding 2-degrees-amines.

  DOI：

  10.1016/s0040-4039(00)91706-4

文献信息

• Method for producing kakeromycin and derivatives thereof
  申请人：OP BIO FACTORY CO., LTD.

  公开号：US11066374B2

  公开（公告）日：2021-07-20

  Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.

  本发明提供了一种通过化学合成生产具有抗真菌活性和细胞毒性并有望成为新型抗真菌剂或抗癌剂的卡克霉素及其衍生物的方法。一种由式（1）代表的化合物的生产方法： 其中 R 是任选取代的烃基或任选取代的杂环基；且 n 是 0 或 1，或其盐，包括将式（2）所代表的化合物进行以下步骤 其中 R 和 n 如上文所定义，或其盐，进行氧化反应。
• METHOD FOR PRODUCING KAKEROMYCIN AND DERIVATIVES THEREOF
  申请人：OP BIO FACTORY CO., LTD.

  公开号：US20190023668A1

  公开（公告）日：2019-01-24

  Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.
• Deoxygenation of N,N-disubstituted hydroxylamines by carbon disulfide
  作者：Martin A. Schwartz、Jiping Gu、Xiufeng Hu

  DOI：10.1016/s0040-4039(00)91706-4

  日期：1992.3

  Hindered N,N-dialkylhydroxylamines react rapidly with CS2 to give the corresponding 2-degrees-amines.