Sysnthesis and DNA Photo-cleaving Activity of Novel Heterocyciclic N-oxide - Acridine Hybrid Molecules
摘要:
The novel DNA photo-cleaver consisting of the heterocyclic N-oxide, which is an efficient photochemical generator of hydroxyl radicals, an acridine intercalator, and an amide-type methylene linker was designed and synthesized. The preliminary DNA strand-breakage study of the hybrid compounds demonstrated that the DNA photo-cleaving activity of the parent heterocyclic N-oxide increased by linking with the acridine intercalator.
Sysnthesis and DNA Photo-cleaving Activity of Novel Heterocyciclic N-oxide - Acridine Hybrid Molecules
摘要:
The novel DNA photo-cleaver consisting of the heterocyclic N-oxide, which is an efficient photochemical generator of hydroxyl radicals, an acridine intercalator, and an amide-type methylene linker was designed and synthesized. The preliminary DNA strand-breakage study of the hybrid compounds demonstrated that the DNA photo-cleaving activity of the parent heterocyclic N-oxide increased by linking with the acridine intercalator.