无色喋呤 | 492-11-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 中文名称: 无色喋呤
• 中文别名: 白喋呤
• 英文名称: 2-Amino-4,6,7-trihydroxypteridin
• 英文别名: Leukopterin；2-amino-5,8-dihydro-3H-pteridine-4,6,7-trione；2-aminopteridine-4,6,7-triol；leucopterin；Leucopterin；2-amino-5,8-dihydro-3H-pteridine-4,6,7-trione
• CAS: 492-11-5
• 化学式: C₆H₅N₅O₃
• mdl: MFCD00047572
• 分子量: 195.137
• InChiKey: SFLOGVVDXPCWGR-UHFFFAOYSA-N

物化性质

• 熔点：
  300 °C
• 沸点：
  331.78°C (rough estimate)
• 密度：
  1.5875 (rough estimate)
• 溶解度：
  可溶于水基（轻微）

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  126
• 氢给体数：
  4
• 氢受体数：
  4

制备方法与用途

制备方法

适用于生化研究和有机合成。

用途简介

暂无具体内容。

上下游信息

• 上游原料

  中文名称	英文名称	CAS号	化学式	分子量
  ——	7-Aminoxanthopterin	71014-14-7	C6H6N6O2	194.153
  ——	Xanthopterin-7-carbonsaeure	2757-91-7	C7H5N5O4	223.148

反应信息

• 作为反应物：
  描述：

  无色喋呤 在 氢氧化钾 、 potassium permanganate 、 sodium amalgam 、 水 作用下， 生成 酵母粉
  参考文献：
  名称：

  Albert; Wood, Journal of Applied Chemistry, 1952, vol. 2, p. 591

  摘要：

  DOI：
• 作为产物：
  描述：

  酵母粉 在 manganese(IV) oxide 、 ammonium hydroxide 、 sodium hydroxide 作用下， 反应 140.0h， 生成 无色喋呤
  参考文献：
  名称：

  ÜberPterinchemie 75. Mitteilung von 7-Aminoxanthopteropterin † ‡的合成

  摘要：

  7-氨基黄嘌呤蝶呤的合成

  DOI：

  10.1002/hlca.19800630708

文献信息

• Regulation of Xanthine Oxidase Activity by Substrates at Active Sites via Cooperative Interactions between Catalytic Subunits: Implication to Drug Pharmacokinetics
  作者：L. A. Tai、K. C. Hwang

  DOI：10.2174/092986711793979760

  日期：2011.1.1

  Three xanthine oxidase substrates (i.e., xanthine, adenine, and 2-amino-4-hydroxypterin) show a “substrate inhibition” pattern (i.e., slower turnover rates at higher substrate concentrations), whereas another two substrates (i.e., xanthopterin and lumazine) show a “substrate activation” pattern (i.e., higher turnover rates at higher substrate concentrations). Binding of a 6-formylpterin at one of the two xanthine oxidase active sites slows down the turnover rate of xanthine at the adjacent active site from 17.0 s-1 to 10.5 s-1, and converts the V-[S] plot from “substrate inhibition” pattern to a classical Michaelis-Menten hyperbolic saturation pattern. In contrast, binding of xanthine at an active site accelerates the turnover rate of 6-formylpterin at the neighboring active site. The experimental results demonstrate that a substrate can regulate the activity of xanthine oxidase via binding at the active sites; or a xanthine oxidase catalytic subunit can simultaneously serve as a regulatory unit. Theoretical simulation based on the velocity equation derived from the extended Michaelis-Menten model shows that the substrate inhibition and the substrate activation behavior in the V-[S] plots could be obtained by introducing cooperative interactions between two catalytic subunits in homodimeric enzymes. The current work confirms that there exist very strong cooperative interactions between the two catalytic subunits of xanthine oxidase.

  三种黄嘌呤氧化酶底物（即黄嘌呤、腺嘌呤和2-氨基-4-羟基吡啶）表现出“底物抑制”模式（即在较高底物浓度下，转化速率较慢），而另两种底物（即黄吡啶和光亮素）则表现出“底物激活”模式（即在较高底物浓度下，转化速率较高）。在两个黄嘌呤氧化酶活性位点中的一个结合6-形式吡啶会使邻近活性位点的黄嘌呤转化速率从17.0 s-1减慢至10.5 s-1，并将V-[S]图从“底物抑制”模式转换为经典的米氏-孟德尔曲线饱和模式。相反，在活性位点结合黄嘌呤会加速邻近活性位点6-形式吡啶的转化速率。实验结果表明，底物可以通过在活性位点的结合调节黄嘌呤氧化酶的活性；同时，黄嘌呤氧化酶的催化亚单位也可以作为调节单位。基于从扩展米氏-孟德尔模型推导出的速率方程的理论模拟表明，V-[S]图中的底物抑制和底物激活行为可以通过引入同源二聚体酶中两个催化亚单位之间的协同作用来获得。目前的研究确认了黄嘌呤氧化酶的两个催化亚单位之间存在非常强的协同作用。
• Oxydation des Xanthopterins in Leukopterin durch Perjodsäure
  作者：M. Viscontini

  DOI：10.1002/hlca.19570400312

  日期：——

  In verdünnter Salzsäurelösung lässt sich Xanthopterin durch Perjodsäure zu Leukopterin oxydieren.

  在稀盐酸溶液中，黄嘌呤蝶呤可被高碘酸氧化为白蝶呤。
• Stripping agent composition and method of stripping
  申请人：——

  公开号：US20040029051A1

  公开（公告）日：2004-02-12

  A stripping composition comprising (a) an anticorrosive agent, (b) a stripping agent and (c) a solvent, wherein the anticorrosive agent (a) is a heterocyclic compound having a nitrogen atom-containing six-membered ring.

  一种剥离组合物，包括 (a) 防腐剂、(b) 剥离剂和 (c) 溶剂，其中防腐剂 (a) 是具有含氮原子六元环的杂环化合物。
• Non-toxic corrosion-protection pigments based on manganese
  申请人：——

  公开号：US20040011252A1

  公开（公告）日：2004-01-22

  Corrosion-inhibiting pigments based on manganese are described that contain a trivalent or tetravalent manganese/valence stabilizer complex. An inorganic or organic material is used to stabilize the trivalent or tetravalent manganese ion to form a compound that is sparingly soluble, exhibits low solubility, or is insoluble in water, depending upon the intended usage. Specific stabilizers are chosen to control the release rate of trivalent or tetravalent manganese during exposure to water and to tailor the compatibility of the powder when used as a pigment in a chosen binder system. Stabilizers may also modify the processing and handling characteristics of the formed powders. Manganese/valence stabilizer combinations are chosen based on the well-founded principles of manganese coordination chemistry. Many manganese-valence stabilizer combinations are presented that can equal the performance of conventional hexavalent chromium or tetravalent lead systems. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.

  以锰为基础的缓蚀颜料含有三价或四价锰/价稳定剂复合物。一种无机或有机材料可用于稳定三价或四价锰离子，从而形成一种可少量溶解、溶解度低或不溶于水的化合物，具体取决于预期用途。选择特定的稳定剂是为了控制三价锰或四价锰在遇水时的释放率，并调整粉末在所选粘合剂体系中用作颜料时的相容性。稳定剂还可以改变成型粉末的加工和处理特性。锰/价稳定剂组合的选择是基于锰配位化学的基本原理。文中介绍了许多锰价稳定剂组合，其性能与传统的六价铬或四价铅体系相当。需要强调的是，提供本摘要是为了符合要求提供摘要的规则，以便检索者或其他读者快速确定技术公开的主题。提交本摘要的前提是，本摘要不用于解释或限制权利要求的范围或含义。
• Non-toxic corrosion-protection pigments based on rare earth elements
  申请人：——

  公开号：US20040104377A1

  公开（公告）日：2004-06-03

  A corrosion-inhibiting pigment comprising a rare earth element and a valence stabilizer combinded to form a rare earth/valence stabilizer complex. The rare earth element is selected from cerium, terbium, praseodymium, or a combination thereof, and at least one rare earth element is in the tetravalent oxidation state. An inorganic or organic material is used to stabilize the tetravalent rare earth ion to form a compound that is sparingly soluble in water. Specific stabilizers are chosen to control the release rate of tetravalent cerium, terbium, or praseodymium during exposure to water and to tailor the compatibility of the powder when used as a pigment in a chosen binder system. Stabilizers may also modify the processing and handling characteristics of the formed powders. Many rare earth-valence stabilizer combinations are presented that can equal the performance of conventional hexavalent chromium systems.

  一种缓蚀颜料，由稀土元素和价态稳定剂结合形成稀土/价态稳定剂复合物。稀土元素选自铈、铽、镨或它们的组合，至少有一种稀土元素处于四价氧化态。使用无机或有机材料来稳定四价稀土离子，以形成稀溶于水的化合物。选择特定的稳定剂是为了控制四价铈、铽或镨在遇水时的释放率，并调整粉末在所选粘合剂体系中用作颜料时的相容性。稳定剂还可以改变成型粉末的加工和处理特性。本文介绍了许多稀土-价稳定剂组合，其性能可与传统的六价铬体系媲美。

表征谱图