benzyldimethylsilylmethyl magnesium chloride | 49759-13-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzyldimethylsilylmethyl magnesium chloride
• CAS: 49759-13-9
• 化学式: C₁₀H₁₅ClMgSi
• 分子量: 223.073
• InChiKey: FSTCHYXRBQTLIR-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  3.29
• 重原子数：
  13.0
• 可旋转键数：
  4.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  0.0
• 氢给体数：
  0.0
• 氢受体数：
  0.0

反应信息

• 作为反应物：
  描述：

  dichloro( 1,5-cyclooctadiene)platinum(ll) 、 benzyldimethylsilylmethyl magnesium chloride 以80%的产率得到bis-[benzyl(dimethyl)silylmethyl](cycloocta-1,5-diene)platinum(II)
  参考文献：
  名称：

  Syntheses and spectroscopic characteristics of bis-[dimethyl(aryl)silylmethyl]-platinum(II) and bis-[dimethyl(benzyl)-silylmethyl]platinum(II) complexes with diene-, nitrogen-, and phosphorus-donor ligands

  摘要：

  The preparations and spectroscopic characteristics of a range of aromatic ring-substituted aryl(dimethyl) silylmethyl (sila-neophyl) complexes of platinum(II) with diene-, nitrogen-, and phosphorus-donor ancillary ligands, cis-Pt(CH(2)SiMe(2)C(6)H(4)R)(2)L(2) (R = H, 2-Me, 3-Me, 4-Me, 4-OMe, 4-(t)Bu, 4-F, 2-CF3, 3-CF3, 4-CF3, 4-NMe(2)) and cis-Pt(CH2Si Me(2)C(6)F(5))(2)L(2) [L = PPh(3), pyridine (py); L(2) = cycloocta-1,5-diene (cod), bicyclo[2.2.1] hepta-2,5-diene (nbd)] are reported. Corresponding characteristics for benzylsilylmethylplatinum analogues, cis-Pt(CH(2)SiMe(2)CH(2)C(6)H(4)R)(2)L(2), (R = H, 4-Me; L(2) = cod; L = PPh(3)) are also presented.

  DOI：

  10.1016/0277-5387(94)00193-i
• 作为产物：
  描述：

  苯甲基(氯甲基)二甲基硅烷 在 magnesium 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 生成 benzyldimethylsilylmethyl magnesium chloride
  参考文献：
  名称：

  Palladium-catalyzed Kumada Coupling Reaction of Bromoporphyrins with Silylmethyl Grignard Reagents: Preparation of Silylmethyl-substituted Porphyrins as a Multipurpose Synthon for Fabrication of Porphyrin Systems

  摘要：

  We have developed an efficient method for preparing silylmethyl-substituted porphyrins via the palladium-catalyzed Kumada cross-coupling reaction of bromoporphyrins with silylmethyl Grignard reagents. We demonstrated the synthetic utility of these silylmethylporphyrins as a multipurpose synthon for fabricating porphyrin derivatives through a variety of transformations of the silylmethyl groups, including the DDQ-promoted oxidative conversion to CHO, CH2OH, CH2OMe, and CH2F functionalities and the fluoride ion-mediated desilylative introduction of carbon-carbon single and double bonds.

  DOI：

  10.1021/jo302122f

文献信息

• Substituted silyl alkylene amines
  申请人：Merrell Pharmaceuticals Inc.

  公开号：US05532397A1

  公开（公告）日：1996-07-02

  This invention relates to substituted silyl alkylene amines, to the intermediates and processes useful for their preparation, to their pharmacological use as MAO-B inhibitors and to their end-use application in the treatment of Parkinson's Disease and senile dementia of Alzheimer's type.

  本发明涉及取代硅烷烯基胺，以及用于它们制备的中间体和工艺，其作为MAO-B抑制剂的药理学用途，以及它们在帕金森病和老年阿尔茨海默病的治疗中的最终应用。
• Synthesis, Structure, and Reactivity of Metal Complexes with Alkoxysilylmethyl Ligands
  作者：Markus Enders、Jochen Fink、Veronique Maillant、Hans Pritzkow

  DOI：10.1002/1521-3749(200109)627:9<2281::aid-zaac2281>3.0.co;2-p

  日期：2001.9

  membered metallacycle. Synthese, Struktur und Reaktivitat von Metallkomplexen mit Alkoxysilylmethyl-Liganden Die Synthese und Eigenschaften der neuen Metallkomplexe 1, 6–12 mit Alkoxysilylmethyl-Substituenten (RO–SiR′2–CH2–MLn) wird beschrieben. Zusatzlich wurden die Komplexe 14, 15 und 18 mit Chloromethylsiloxy-Liganden hergestellt. Diese Molekule sollten als Edukte zur Synthese von Metallasilaoxetanen

  描述了具有烷氧基甲硅烷基甲基取代基 (RO – SiR'2 – CH2 – MLn) 的新型金属配合物 1, 6-12 的合成和性质。还制备了具有氯甲基甲硅烷氧基配体的配合物14、15和18。这些分子应作为合成金属硅氧杂环丁烷的起始化合物。已经进行了几个应该导致这些新金属环的反应，但永远不可能分离它们或用光谱证明它们的存在。然而，银阳离子从 (C5H5) 2Ti (Cl) Si (CH3) 2OtBu (7) 中提取氯化物导致 Si-O-R 基团的活化。这表明氧原子与金属原子相互作用，但没有证据表明中间形成四元金属环。合成，具有烷氧基甲硅烷基甲基配体的金属配合物的结构和反应性 描述了具有烷氧基甲硅烷基甲基取代基 (RO – SiR'2 – – MLn) 的新金属配合物 1, 6-12 的合成和性质。此外，配合物 14、15 和 18 是用氯甲基甲硅烷氧基配体制备的。这些分子应
• Synthetic approaches towards 4-(silylmethyl)-2-azetidinones
  作者：Cristina Nativi、Enzo Perrotta、Alfredo Ricci、Maurizio Taddei

  DOI：10.1016/s0040-4039(00)79698-5

  日期：1991.5

  Differently substituted 4-(silylmethyl)-2-azetidinones were prepared starting form the corresponding 4-acetoxy-2-azetidinones with silylmethylmagnesium chlorides. The same kind of beta-lactams were synthesized ''via'' cycloaddition of allylsilanes and chlorosulfonyl isocyanate (CSI).
• STUDIES OF TRIS-[(DIMETHYLBENZYLSILYL)METHYLENE]TIN MONO(DI)THIOPHOSPHATES
  作者：Hua Liu、Qing-Lan Xie、Songlan Li、Ji-Tao Wang

  DOI：10.1080/10426509708033709

  日期：1997.11

  Twenty-five new compounds of the form (PhCH2Me2SiCH2)(3)SnSP(X)(OR1)(OR2)(X = O:R-1 = C2H5, R-2 = Substituted phenyl; X = S:R-1 = R-2 = hydrocarbyl) have been synthesized. Their structures were characterized by IR, H-1, Sn-119, (31)p NMR, MS and elemental analyses, Sn-119 NMR measurement of chemical shift have shown that there is a good linear relationship of Sn-119 chemical shift with para-substituent Hammett constants.