5-(methylthio)pentan-1-ol | 57774-99-9

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 5-(methylthio)pentan-1-ol
• 英文别名: 5-methylsulfanyl-pentan-1-ol；α-Oxy-ε-methylmercapto-pentan；Monothiopentamethylenglykol-S-methylaether；Methyl-(ε-oxy-n-amyl)-sulfid；5-Methylmercapto-pentan-1-ol；5-methylsulfanylpentan-1-ol；5-(Methylsulfanyl)pentan-1-ol
• CAS: 57774-99-9
• 化学式: C₆H₁₄OS
• mdl: MFCD09926783
• 分子量: 134.243
• InChiKey: ZTCHYZLZZVVQLA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  8
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  45.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-(methylthio)pentan-1-ol 在 氯化亚砜 、 potassium iodide 作用下， 以 乙醇 为溶剂， 生成 6-(methylsulfanyl)hexanenitrile
  参考文献：
  名称：

  Truce,W.E. et al., Journal of Organic Chemistry, 1962, vol. 27, p. 2821 - 2828

  摘要：

  DOI：
• 作为产物：
  描述：

  2-(2-methylthio)tetrahydropyran 在 lithium aluminium tetrahydride 、 三氯化铝 作用下， 以 乙醚 为溶剂， 生成 5-(methylthio)pentan-1-ol
  参考文献：
  名称：

  Endocyclic vs. exocyclic attack in nucleophilic displacement reactions on five- and six-membered cyclic onium salts

  摘要：

  DOI：

  10.1021/jo00868a027

文献信息

• [EN] TREATMENT OF HELICOBACTER PYLORI INFECTIONS<br/>[FR] TRAITEMENT DES INFECTIONS À HELICOBACTER PYLORI
  申请人：EINSTEIN COLL MED

  公开号：WO2014025842A1

  公开（公告）日：2014-02-13

  Methods of treating infections due to Helicobacter pylori (H. pylori), in particular in subjects having a peptic ulcer, are disclosed where the methods comprise administering inhibitors of H. pylori MTAN (5'-methylthioadenosine nucleosidase) to the subject.

  治疗幽门螺杆菌（H. pylori）感染的方法，特别是在患有消化性溃疡的患者中，包括向患者施用H. pylori MTAN（5'-甲硫腺苷核苷酸酶）抑制剂的方法。
• METHOD FOR THE DECARBOXYLATIVE HYDROFORMYLATION OF ALPHA, BETA- UNSATURATED CARBOXYLIC ACIDS
  申请人：Rudolph Jens

  公开号：US20110028746A1

  公开（公告）日：2011-02-03

  The present invention relates to a process for preparing aldehydes by reacting an α,β-unsaturated carboxylic acid or a salt thereof with carbon monoxide and hydrogen in the presence of a catalyst comprising at least one complex of a metal of transition group VIII of the Periodic Table of the Elements with at least one compound of the formula (I), where Pn is pnicogen; W is a divalent bridging group having from 1 to 8 bridge atoms between the flanking bonds; R 1 is a functional group capable of forming at least one intermolecular, noncovalent bond with the —X(═O)OH group of the compound of the formula (I); R 2 , R 3 are each in each case optionally substituted alkyl, cycloalkyl, heterocycloalkyl, aryl or hetaryl or together with the pnicogen atom and together with the groups Y 2 and Y 3 if present form an optionally fused and optionally substituted 5- to 8-membered heterocycle; a, b and c are each 0 or 1; and Y 1,2,3 are each, independently of one another, O, S, NR a or SiR b R c , where R a,b,c are each H or in each case optionally substituted alkyl, cycloalkyl, heterocycloalkyl, aryl or hetaryl; and the use of the above-described catalyst for the decarboxylative hydroformylation of α,β-unsaturated carboxylic acids.

  本发明涉及一种通过在过渡元素周期表第VIII族金属的至少一个配合物存在下，将α，β-不饱和羧酸或其盐与一氧化碳和氢反应制备醛的方法，所述配合物的化学式为(I)，其中Pn为氮族元素；W为具有1到8个桥连原子的二价桥联基团；R1为能够与化合物的化学式(I)中的—X(═O)OH基团形成至少一种分子间非共价键的官能团；R2、R3在每种情况下均为可选择的取代烷基、环烷基、杂环烷基、芳基或杂芳基，或者与氮族原子以及Y2和Y3基团（如存在）一起形成一个可选择的融合和可选择的取代的5到8元杂环；a、b和c分别为0或1；Y1、2、3各自独立地为O、S、NRa或SiRbRc，其中Ra、b、c各自为H或可选择的取代烷基、环烷基、杂环烷基、芳基或杂芳基；以及上述催化剂用于α，β-不饱和羧酸的脱羧氢甲酰化。
• Pyrimidine nucleoside derivatives having anti-tumor activity, their preparation and use
  申请人：Sankyo Company Limited

  公开号：EP0536936A1

  公开（公告）日：1993-04-14

  Compounds of formula (I): [in which: R¹, R² and R³ are the same or different and each represents a hydrogen atom, an optionally substituted alkanoyl group or an alkenylcarbonyl group, provided that at least one of R¹, R² and R³ represents an unsubstituted alkanoyl group having from 5 to 24 carbon atoms, said substituted alkanoyl group or said alkenylcarbonyl group; and one of R⁴ and R⁵ represents a hydrogen atom and the other represents a cyano group]; have valuable anti-tumour activity.

  式子（I）的化合物：[其中：R¹、R²和R³相同或不同，每个代表氢原子、可选取代的脂肪酰基团或烯基羰基团，前提是至少有一个R¹、R²和R³代表有5到24个碳原子的未取代脂肪酰基团，或者是所述取代的脂肪酰基团或所述烯基羰基团；R⁴和R⁵中的一个代表氢原子，另一个代表氰基]，具有有价值的抗肿瘤活性。
• N-heteroarylnicotinamide derivatives
  申请人：Mio Shigeru

  公开号：US20050004368A1

  公开（公告）日：2005-01-06

  An N-heteroaryl-4-(haloalkyl)nicotinamide derivative represented by formula (I): [wherein R represents a C 1 -C 6 haloalkyl group; R 1 represents a hydrogen atom, a C 1 -C 6 alkyl group which may be substituted a C 2 -C 6 alkenyl group or an acyl group; X represents a group represented by formula C—R 2 , or a nitrogen atom; R 2 and R 3 each independently represent a hydrogen atom, a halogen atom, a C 1 -C 6 alkyl group which may be substituted, a C 3 -C 7 cycloalkyl group, a C 2 -C 6 alkenyl group, a C 3 -C 7 cycloalkenyl group, a formyl group, a group represented by formula CH═NOR 4 , a cyano group, a phenyl group which may be substituted, a heterocyclic group which may be substituted, a C 1 -C 6 alkoxy group which may be substituted, a C 1 -C 6 alkylthio group or a phenoxy group]; or a salt thereof, a pesticide containing it as an active component, a method for producing it and intermediates thereof.

  公式（I）所表示的N-杂环基-4-（卤代烷基）烟酰胺衍生物：[其中R表示C1-C6卤代烷基；R1表示氢原子，C1-C6烷基，可以被取代的C2-C6烯基或酰基；X表示由公式C—R2表示的基团，或氮原子；R2和R3各自独立地表示氢原子，卤素原子，可以被取代的C1-C6烷基，C3-C7环烷基，C2-C6烯基，C3-C7环烯基，甲酰基，由公式CH═NOR4表示的基团，氰基，可以被取代的苯基，可以被取代的杂环基，可以被取代的C1-C6烷氧基，C1-C6烷基硫基或苯氧基]；或其盐，作为活性成分的杀虫剂，其生产方法及中间体。
• Beta-amyloid protein production. secretion inhibitor
  申请人：Yasukouchi Takanori

  公开号：US20050234109A1

  公开（公告）日：2005-10-20

  Provided are novel compounds having an inhibitory activity against production or secretion of β-amyloid protein. They embrace compounds represented by the following formula (1): and capable of being replaced with a variety of substituents; and salts thereof, and solvates of any one of them.

  提供了一种新型化合物，具有抑制β-淀粉样蛋白产生或分泌的活性。它们包括由以下公式（1）表示的化合物：并且能够被各种取代基所替换；以及它们的盐和任何一个溶剂化物。