2-methoxy-5-(trimethylsilylacetylenyl)benzaldehyde | 1202818-85-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-methoxy-5-(trimethylsilylacetylenyl)benzaldehyde
• 英文别名: 2-Methoxy-5-(2-trimethylsilylethynyl)benzaldehyde
• CAS: 1202818-85-6
• 化学式: C₁₃H₁₆O₂Si
• 分子量: 232.354
• InChiKey: RZAAXAKUQMZMAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.74
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-methoxy-5-(trimethylsilylacetylenyl)benzaldehyde 在 甲醇 、 potassium carbonate 作用下， 反应 0.5h， 以100%的产率得到5-乙炔基-2-甲氧基苯甲醛
  参考文献：
  名称：

  Synthesis of 5-ortho-Carboranylsalicylaldehyde and an Indolinospirobenzopyran

  摘要：

  5-ortho-Carboranylsalicylaldehyde was prepared from 5-iodosalicylaldehyde in six steps in 18% overall yield, and also from 5-iodosalicylic acid in seven steps in 45% overall yield. The reaction of 5-ortho-carboranylsalicylaldehyde with Fischer's base gave a spiropyran in 63% yield.

  DOI：

  10.1080/00397910902883694
• 作为产物：
  描述：

  碘甲烷 、 2-hydroxy-5-((trimethylsilyl)ethynyl)benzaldehyde 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 0.5h， 以94.2%的产率得到2-methoxy-5-(trimethylsilylacetylenyl)benzaldehyde
  参考文献：
  名称：

  Synthesis of 5-ortho-Carboranylsalicylaldehyde and an Indolinospirobenzopyran

  摘要：

  5-ortho-Carboranylsalicylaldehyde was prepared from 5-iodosalicylaldehyde in six steps in 18% overall yield, and also from 5-iodosalicylic acid in seven steps in 45% overall yield. The reaction of 5-ortho-carboranylsalicylaldehyde with Fischer's base gave a spiropyran in 63% yield.

  DOI：

  10.1080/00397910902883694

文献信息

• Synthesis of 5-<i>ortho</i>-Carboranylsalicylaldehyde and an Indolinospirobenzopyran
  作者：Seung Hwan Lee、Young Bum Kwon、Cheol Min Yoon

  DOI：10.1080/00397910902883694

  日期：2009.10.21

  5-ortho-Carboranylsalicylaldehyde was prepared from 5-iodosalicylaldehyde in six steps in 18% overall yield, and also from 5-iodosalicylic acid in seven steps in 45% overall yield. The reaction of 5-ortho-carboranylsalicylaldehyde with Fischer's base gave a spiropyran in 63% yield.