5-Dimethoxymethyl-2-ethyl-1,3-dimethoxy-benzene | 140464-73-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-Dimethoxymethyl-2-ethyl-1,3-dimethoxy-benzene
• 英文别名: 5-(Dimethoxymethyl)-2-ethyl-1,3-dimethoxybenzene；5-(dimethoxymethyl)-2-ethyl-1,3-dimethoxybenzene
• CAS: 140464-73-9
• 化学式: C₁₃H₂₀O₄
• 分子量: 240.299
• InChiKey: QFOHNVWDYMIKJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-Dimethoxymethyl-2-ethyl-1,3-dimethoxy-benzene 在 盐酸 作用下， 以 四氢呋喃 、 水 为溶剂， 以1.67 g的产率得到4-ethyl-3,5-dimethoxybenzaldehyde
  参考文献：
  名称：

  DESOXYSCALINE DERIVATIVES WITH MODIFIED MESCALINE-LIKE ACTION

  摘要：

  A composition of a compound represented by FIG. 1 for use in substance-assisted therapy. A method of changing neurotransmission, by administering a pharmaceutically effective amount of a compound of FIG. 1 to a mammal, interacting with serotonin 5 -HT 2 A receptors in the mammal, in particular also human beings, and inducing psychoactive effects. A method of treating a patient having adverse reactions to psychedelics by administering a desoxyscaline derivative to the patient, and avoiding adverse effects present with psychedelics. A method of changing neurotransmission of an individual, by administering a desoxyscaline derivative, and changing neurotransmission in the individual.

  公开号：

  US20230150906A1
• 作为产物：
  描述：

  3,4,5-三甲氧基苯甲醛 在 sodium 、 氯化铵 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 26.7h， 生成 5-Dimethoxymethyl-2-ethyl-1,3-dimethoxy-benzene
  参考文献：
  名称：

  DESOXYSCALINE DERIVATIVES WITH MODIFIED MESCALINE-LIKE ACTION

  摘要：

  A composition of a compound represented by FIG. 1 for use in substance-assisted therapy. A method of changing neurotransmission, by administering a pharmaceutically effective amount of a compound of FIG. 1 to a mammal, interacting with serotonin 5 -HT 2 A receptors in the mammal, in particular also human beings, and inducing psychoactive effects. A method of treating a patient having adverse reactions to psychedelics by administering a desoxyscaline derivative to the patient, and avoiding adverse effects present with psychedelics. A method of changing neurotransmission of an individual, by administering a desoxyscaline derivative, and changing neurotransmission in the individual.

  公开号：

  US20230150906A1

文献信息

• Synthesis of Antibiotic Stilbenes by Reductive Metalation of 3,4,5-Trimethoxybenzaldehyde Dimethyl Acetal
  作者：Ugo Azzena、Maria Vittoria Idini、Luciano Pilo

  DOI：10.1081/scc-120018690

  日期：2003.1.5

  Reductive metalation of 3,4,5-trimethoxybenzaldehyde dimethyl acetal followed by reaction with suitable electrophiles is the key step of a reaction sequence leading to the synthesis of naturally occurring 4-alkyl-3,5-dihydroxy-substituted trans-stilbenes having antibiotic activity.
• DESOXYSCALINE DERIVATIVES WITH MODIFIED MESCALINE-LIKE ACTION
  申请人：Mind Medicine, Inc.

  公开号：US20230150906A1

  公开（公告）日：2023-05-18

  A composition of a compound represented by FIG. 1 for use in substance-assisted therapy. A method of changing neurotransmission, by administering a pharmaceutically effective amount of a compound of FIG. 1 to a mammal, interacting with serotonin 5 -HT 2 A receptors in the mammal, in particular also human beings, and inducing psychoactive effects. A method of treating a patient having adverse reactions to psychedelics by administering a desoxyscaline derivative to the patient, and avoiding adverse effects present with psychedelics. A method of changing neurotransmission of an individual, by administering a desoxyscaline derivative, and changing neurotransmission in the individual.