四甲基弧-2-乙基己酯 | 4347-99-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 四甲基弧-2-乙基己酯
• 英文名称: 1,1,3,3-tetramethylguanidinium 2-ethylhexanoate
• 英文别名: (N,N-dimethylcarbamimidoyl)-dimethylazanium;2-ethylhexanoate
• CAS: 4347-99-3
• 化学式: C₅H₁₃N₃*C₈H₁₆O₂
• 分子量: 259.392
• InChiKey: IRQKNGBRWKGEOJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.33
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  67.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-乙基-己酸稀土盐 、 四甲基胍 生成 四甲基弧-2-乙基己酯
  参考文献：
  名称：

  带有萘或or部分的硅氧烷桥连的环状二聚体的光学和电子性质

  摘要：

  描述了具有萘基（CD1）或pyr基（CD2）部分的新型硅氧烷桥联环状二聚体的光学和电子性质。CD1和CD2分别通过1，4-双（二甲基羟基甲硅烷基）萘（M1）和1，6-双（二甲基羟基甲硅烷基）py（M2）的环状二聚而获得。由于CD1和CD2中的芳基部分之间的距离短，因此CD1和CD2主要表现出受激准分子的发射，根据X射线晶体学分析，它们之间的距离分别为3.44Å和3.41Å。CD2的吸收光谱在存在7,7,8,8-四氰基喹二甲烷（TCNQ）的情况下，CD2具有与TCNQ形成1：1电荷转移络合物的能力，这表明在紧靠pyr分子之间存在跨环π-π相互作用。CD2。

  DOI：

  10.1016/j.tet.2010.08.010
• 作为试剂：
  描述：

  1,6-bis(dimethylhydroxysilyl)pyrene 在 四甲基弧-2-乙基己酯 作用下， 以 甲苯 为溶剂， 以44.6%的产率得到8,8,10,10,27,27,29,29-Octamethyl-9,28-dioxa-8,10,27,29-tetrasilanonacyclo[28.8.0.04,37.07,36.011,20.014,19.017,26.018,23.033,38]octatriaconta-1(30),2,4(37),5,7(36),11(20),12,14(19),15,17(26),18(23),21,24,31,33(38),34-hexadecaene
  参考文献：
  名称：

  带有萘或or部分的硅氧烷桥连的环状二聚体的光学和电子性质

  摘要：

  描述了具有萘基（CD1）或pyr基（CD2）部分的新型硅氧烷桥联环状二聚体的光学和电子性质。CD1和CD2分别通过1，4-双（二甲基羟基甲硅烷基）萘（M1）和1，6-双（二甲基羟基甲硅烷基）py（M2）的环状二聚而获得。由于CD1和CD2中的芳基部分之间的距离短，因此CD1和CD2主要表现出受激准分子的发射，根据X射线晶体学分析，它们之间的距离分别为3.44Å和3.41Å。CD2的吸收光谱在存在7,7,8,8-四氰基喹二甲烷（TCNQ）的情况下，CD2具有与TCNQ形成1：1电荷转移络合物的能力，这表明在紧靠pyr分子之间存在跨环π-π相互作用。CD2。

  DOI：

  10.1016/j.tet.2010.08.010

文献信息

• Silicone pressure-sensitive adhesive process and product thereof
  申请人：DOW CORNING CORPORATION

  公开号：EP0183379A2

  公开（公告）日：1986-06-04

  This invention relates to silicone pressure-sensitive adhesives having improved viscosity stability and film physical property stability upon aging by a method comprising the condensation of a benzene-soluble resin copolymer of 0.6 to 0.9 triorganoxiloxy units per SiO4/2 unit which contains silicon-bonded hyroxyl radicals and a polydiorganosiloxane preferably containing silicon-bonded hydroxyl or other hydrolyzable endblocking radicals with a sufficient amount of an endblocking agent containing endblocking triorganosilyl units such as hexamethyldisilazane or trimethylmethoxysilane to result in a 1:0.8 to 1:3 mole ratio of silicon-bonded hydroxyl radicals and hydrolyzable endblocking radicals to total moles of triorganosilyl units provided by the endblocking agent. The condensation is conducted, when desirable, in the presence of a catalytic amount of a mild silanol condensation catalyst if one is not provided by endblocking agent and, when necessary, in the presence of an effective amount of an organic solvent such as xylene. Condensation is preferably conducted with heating under solvent reflux conditions.

  本发明涉及一种有机硅压敏粘合剂，该粘合剂在老化后具有更好的粘度稳定性和薄膜物理性能稳定性，其方法包括将每 SiO4/2 单元含 0.6 至 0.9 个三有机硅氧基单元的苯溶性树脂共聚物（该共聚物含有硅键合羟基）和一种聚二有机硅氧烷（优选含有硅键合羟基或其他水解基）缩合。9个三有机硅氧基单元的苯溶性树脂共聚物，该共聚物含有硅键合羟基和聚二有机硅氧烷，其中聚二有机硅氧烷最好含有硅键合羟基或其他可水解的末端阻断基，该聚二有机硅氧烷含有足量的末端阻断剂，该末端阻断剂含有末端阻断的三有机硅单元，例如六甲基二硅氮烷或三甲基甲氧基硅烷，从而形成1:0.8至1:3的摩尔比。如果末端封端剂没有提供温和的硅醇缩合催化剂，则在需要时，在有效量的有机溶剂（如二甲苯）存在下进行缩合。缩合最好在溶剂回流条件下加热进行。
• Transdermal drug delivery device with amine-resistant silicone adhesive and method for making such a device
  申请人：DOW CORNING CORPORATION

  公开号：EP0180377A2

  公开（公告）日：1986-05-07

  This invention relates to an improved transdermal drug delivery device for the controlled transdermal delivery of amino-functional drugs. The improvement resides in providing the device with a silicone pressure-sensitive adhesive layer which has been chemically treated to reduce the silicon-bonded hydroxyl content of the pressure-sensitive adhesive composition to render the adhesive layer resistant to loss of tack and preserve the instant adherence of the device to the skin of a wearer during storage and while the device is being worn. Preferably, the composition used comprises a silicon-bonded hydroxyl radical containing resinous copolymer of R3SiO1/2 units and Si04;2 units and a polydiorganosiloxane which have been chemically treated with R3SiO1/2 units where R is preferably a hydrocarbon radical such as a methyl group to reduce the silicon-bonded hydroxyl content of the adhesive and thereby its sensitivity to amino-functional drugs.

  本发明涉及一种改进的透皮给药装置，用于控制氨基功能药物的透皮给药。改进之处在于为该装置提供了一个硅酮压敏胶层，该层经过化学处理，以减少压敏胶组合物中硅键羟基的含量，从而使胶层不易失去粘性，并在储存期间和装置佩戴时保持装置与佩戴者皮肤的即时粘附性。优选地，所使用的组合物包括含有硅键羟基的 R3SiO1/2 单元和 Si04;2 单元的树脂共聚物，以及经过 R3SiO1/2 单元化学处理的聚二有机硅氧烷，其中 R 最好是烃基，如甲基，以减少粘合剂中的硅键羟基含量，从而降低其对氨基官能团药物的敏感性。
• Process for the production of organosilicon compounds
  申请人：Dow Corning Limited

  公开号：EP0382367A2

  公开（公告）日：1990-08-16

  Process for the production of organosilicon condensation products which comprises contacting (A) at least one organo­silicon compound having in the molecule at least one silanol group, the organic substituents being selected from monovalent hydrocarbon groups having from 1 to 14 carbon atoms and monova­lent substituted hydrocarbon groups having from 1 to 10 carbon atoms, and (B) a borate or phosphate of sodium or potassium. The condensation products find application in, for example textile treatments and paper coating.

  有机硅缩合产品的生产工艺，包括将(A)至少一种有机硅化合物与(B)一种硼酸盐或磷酸钠或磷酸盐（分子中至少有一个硅烷醇基，有机取代基选自具有 1 至 14 个碳原子的一价烃基和具有 1 至 10 个碳原子的一价取代烃基）接触。 缩合产品可用于纺织品处理和纸张涂层等领域。
• Pressure sensitive adhesive compositions for transdermal drug delivery devices
  申请人：DOW CORNING CORPORATION

  公开号：EP1025843A2

  公开（公告）日：2000-08-09

  A transdermal drug delivery device for the controlled transdermal delivery of an active pharmaceutical agent is disclosed. The device comprises a drug delivery device comprising an active pharmaceutical agent and a means for its controlled delivery through the skin; and (B) a silicone pressure sensitive adhesive for maintaining contact between the device and the skin of a wearer. The silicone pressure sensitive adhesive comprises silicone resin copolymer and a polydiorganosiloxane and has a silanol concentration in the range of between 8000 and 13,000 ppm. The present invention also teaches methods for producing the above silicone pressure sensitive adhesive compositions.

  本发明公开了一种用于控制活性药剂透皮给药的透皮给药装置。该装置包括：(A) 由活性药剂组成的给药装置和通过皮肤控制给药的装置；(B) 用于保持装置与穿戴者皮肤之间接触的硅酮压敏胶。硅酮压敏胶由硅树脂共聚物和聚二有机硅氧烷组成，硅醇浓度在 8000 至 13000 ppm 之间。本发明还教导了生产上述硅酮压敏胶组合物的方法。
• RE-ADHERABLE SILICONE-BASED ADHESIVE COMPOSITION, SHEET-SHAPED BASE MATERIAL HAVING RE-ADHERABLE ADHESIVE LAYER OBTAINED BY CURING SAID COMPOSITION, AND USE OF SAID BASE MATERIAL AS PROTECTIVE FILM OR AFFIXING SHEET
  申请人：Dow Corning Toray Co., Ltd.

  公开号：EP2524954A1

  公开（公告）日：2012-11-21

  Problem: To provide a silicone-based releasable adhesive composition that is capable of easily controlling peeling force of a releasable adhesive layer by the composition, and whereby the silicone-based releasable adhesive composition has excellent attachment characteristics and releasability characteristics. A further object is to provide a sheet-form substrate and a releasable adhesive sheet that have a releasable adhesive layer formed by curing this composition. Resolution Means: The silicone-based releasable adhesive composition includes an organopolysiloxane resin-organopolysiloxane condensation reaction product obtained by condensation reaction between (a1) 100 weight parts of an MQ type organopolysiloxane resin containing hydroxyl groups or alkoxy groups in a range of 0.3 to 2.0 weight% and having an M unit to Q unit molar ratio of 0.6 to 1.0, and (a2) 20 to 150 weight parts of a chain-like diorganopolysiloxane having an average degree of polymerization of 100 to 1,000 and having at least one hydroxyl group or alkoxy group, wherein the organopolysiloxane resin-organopolysiloxane condensation reaction product preferably includes a certain hydroxyl group content.

  问题：提供一种硅酮基可释放粘合剂组合物，该组合物能够轻松控制可释放粘合剂层的剥离力，并且硅酮基可释放粘合剂组合物具有优异的附着特性和可释放特性。另一个目的是提供一种片状基材和可释放粘合剂片材，它们具有通过固化该组合物形成的可释放粘合剂层。 解决手段：硅酮基可释放粘合剂组合物包括有机聚硅氧烷树脂-有机聚硅氧烷缩合反应产物，该缩合反应产物由以下物质缩合反应得到：(a1) 100 重量份的 MQ 型有机聚硅氧烷树脂，该树脂含有羟基或烷氧基，其羟基或烷氧基的重量百分比范围为 0.3 至 2.0，且 M 单位与 Q 单位的摩尔比为 0.6至1.0，以及(a2)20至150重量份的平均聚合度为100至1,000并具有至少一个羟基或烷氧基的链状二甘醇聚硅氧烷，其中有机聚硅氧烷树脂-有机聚硅氧烷缩合反应产物最好包括一定的羟基含量。