3-(2-甲氧基-苯氧基)-苯胺 | 116289-62-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-(2-甲氧基-苯氧基)-苯胺
• 英文名称: 3-(2-methoxy-phenoxy)-aniline
• 英文别名: 3-(2-Methoxy-phenoxy)-anilin；[3-(2-methoxyphenoxy)phenyl]amine；3-(2-methoxyphenoxy)aniline；3-(2-methoxyphenoxy)Benzenamine
• CAS: 116289-62-4
• 化学式: C₁₃H₁₃NO₂
• 分子量: 215.252
• InChiKey: WIWJQECJEQEZSU-UHFFFAOYSA-N

物化性质

• 沸点：
  348.1±17.0 °C(Predicted)
• 密度：
  1.155±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  44.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(2-甲氧基-苯氧基)-苯胺 在 吡啶 作用下， 以 1,2-二氯乙烷 为溶剂， 生成 2,2,2-trifluoro-N-[3-(2-methoxyphenoxy)phenyl]-N-(pyrimidin-5-ylmethyl)ethanesulfonamide
  参考文献：
  名称：

  Pyrimidine methyl anilines: selective potentiators for the metabotropic glutamate 2 receptor

  摘要：

  Pyrimidine methyl anilines as potent and selective mGlu2 potentiators are described. Findings from the structure-activity-relationship investigations are discussed. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.07.079
• 作为产物：
  描述：

  1-methoxy-2-(3-nitro-phenoxy)-benzene 在 镍 氢气 作用下， 以 甲醇 为溶剂， 反应 18.0h， 生成 3-(2-甲氧基-苯氧基)-苯胺
  参考文献：
  名称：

  Potentiators of glutamate receptors

  摘要：

  本发明涉及代谢型谷氨酸受体功能的增强剂，具体提供了化合物I的公式、其组合物以及使用方法。

  公开号：

  US20040006114A1

文献信息

• Potentiators of glutamate receptors
  申请人：——

  公开号：US20040006114A1

  公开（公告）日：2004-01-08

  The present invention relates to potentiators of metabotropic glutamate receptor function and specifically provides compounds of formula I, compositions thereof and methods of using the same. 1

  本发明涉及代谢型谷氨酸受体功能的增强剂，具体提供了化合物I的公式、其组合物以及使用方法。
• Substituted quinolines as antitumor agents
  申请人：——

  公开号：US20040029898A1

  公开（公告）日：2004-02-12

  The invention provides a compound of Formula (Ia), or a pharmaceutically acceptable salt. prodrug or solvate thereof. The invention also provides a process for the preparation of a compound of Formula (Ia), pharmaceutical compositions of a compound of Formula (Ia) and methods for the treatment or prevention of cancer comprising administering an effective amount of a compound of Formula (Ia).

  该发明提供了化合物Ia的结构，或者其药用可接受的盐、前药或溶剂化合物。该发明还提供了一种制备化合物Ia的方法，化合物Ia的药用组合物以及治疗或预防癌症的方法，包括给予有效量的化合物Ia。
• 1H,3H-pyrrol[1,2-c]thiazole derivatives and pharmaceutical compositions
  申请人：Rhone-Poulenc Sante

  公开号：US04783472A1

  公开（公告）日：1988-11-08

  A compound of the general formula I; ##STR1## in which R is hydrogen or a halogen or an alkyl, alkyloxy, alkylthio, trifluoromethyl, amino, alkylamino, dialkylamino, hydroxy, cyano, carboxy, alkylsulphinyl, alkylsulphonyl, sulphamido, alkylsulphamido, dialkylsulphamido, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, phenylcarbamoyl, diphenylcarbamoyl, pyridylcarbamoyl, dipyridylcarbamoyl, benzyl, alkylcarbonyl, benzoyl, alkyloxycarbonyl, phenoxycarbonyl, alkylcarbonyloxy, benzoyloxy, alkylcarbonylamino, benzamido, phenyl, phenoxy or phenylthio group, X is oxygen or sulphur or an imino, alkylimino, phenylimino, benzylimino, sulphinyl, sulphonyl, carbonyl, carbonylmethylene, methylenecarbonyl, carbonylvinylene or vinylenecarbonyl group, or X represents a valency bond or a straight-chain alkylene group containing 1 to 4 carbon atoms and Ar is a phenyl, naphthyl, pyridyl, quinolinyl, isoquinolinyl, thienyl, benzothienyl, thieno[3,2-b]thien-2-yl or thieno[2,3-b]thien-2-yl group, it being possible for the group Ar to be unsubstituted or substituted with one or more halogen or alkyl, alkyloxy, alkylthio, trifluoromethyl, amino, alkylamino, dialkylamino, hydroxy, cyano, carboxy, alkylsulphinyl, alkylsulphonyl, sulphamido, alkylsulphamido, dialkylsulphamido, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, phenylcarbamoyl, diphenylcarbamoyl, pyridylcarbamoyl, dipyridylcarbamoyl, benzyl, alkylcarbonyl, benzoyl, alkyloxycarbonyl, phenoxycarbonyl, alkylcarbonyloxy, benzoyloxy, alkylcarbonylamino or benzamido group; each alkyl moiety containing 1 to 4 straight- or branched-chain carbon atoms; the compound being in separate enantiomeric form or mixtures thereof or a pharmaceutically acceptable salt thereof is useful in the treatment of all the pathological conditions in which PAF-acether may be directly or indirectly implicated.

  通式为I的化合物；##STR1## 其中R是氢或卤素或烷基，烷氧基，烷硫基，三氟甲基，氨基，烷基氨基，二烷基氨基，羟基，氰基，羧基，烷基磺酰基，烷基磺酰基，磺酰胺基，烷基磺酰胺基，二烷基磺酰胺基，氨基甲酰基，烷基氨甲酰基，二烷基氨甲酰基，苯基氨甲酰基，二苯基氨甲酰基，吡啶基氨甲酰基，二吡啶基氨甲酰基，苄基，烷基羰基，苯甲酰基，烷氧羰酰基，苯氧羰酰基，烷基羰酰氧基，苯甲酰氧基，烷基羰基氨基，苯甲酰胺基，苯基，苯氧基或苯硫基，X是氧或硫或亚胺基，烷基亚胺基，苯基亚胺基，苄基亚胺基，磺酰基，磺酰基，羰基，羰基亚甲基，羰基乙烯基或乙烯基羰基基团，或X表示价键或含有1到4个碳原子的直链烷基基团，Ar是苯基，萘基，吡啶基，喹啉基，异喹啉基，噻吩基，苯并噻吩基，噻吩[3,2-b]噻吩-2-基或噻吩[2,3-b]噻吩-2-基团，其中Ar基团可能是未取代或取代一个或多个卤素或烷基，烷氧基，烷硫基，三氟甲基，氨基，烷基氨基，二烷基氨基，羟基，氰基，羧基，烷基磺酰基，烷基磺酰基，磺酰胺基，烷基磺酰胺基，二烷基磺酰胺基，氨基甲酰基，烷基氨甲酰基，二烷基氨甲酰基，苯基氨甲酰基，二苯基氨甲酰基，吡啶基氨甲酰基，二吡啶基氨甲酰基，苄基，烷基羰基，苯甲酰基，烷氧羰酰基，苯氧羰酰基，烷基羰酰氧基，苯甲酰氧基，烷基羰基氨基，苯甲酰胺基或苯基氨基基团；每个烷基含有1到4个直链或支链碳原子；该化合物以分离的对映异构体形式或其混合物或其药学上可接受的盐形式在PAF-acether可能直接或间接涉及的所有病理情况的治疗中有用。
• Pyrimidine and Quinoline Potentiators of Metabotropic Glutamate Receptors
  申请人：Hu H. Essa

  公开号：US20070287716A1

  公开（公告）日：2007-12-13

  The present invention is directed to compounds which are potentiators of metabotropic glutamate receptors, including the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.

  本发明涉及化合物，它们是代谢型谷氨酸受体的增强剂，包括mGluR2受体，可用于治疗或预防与谷氨酸功能障碍有关的神经和精神障碍以及代谢型谷氨酸受体参与的疾病。本发明还涉及包含这些化合物的制药组合物以及在预防或治疗代谢型谷氨酸受体参与的这种疾病中使用这些化合物和组合物。
• AMINOMETHYL-4-IMIDAZOLES
  申请人：Galley Guido

  公开号：US20080119535A1

  公开（公告）日：2008-05-22

  The present invention relates to amino-4-methyl imidazoles and pharmaceutically-acceptable salts thereof. The compound may be used for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder (ADHD), stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.

  本发明涉及氨基-4-甲基咪唑及其药学可接受的盐。该化合物可用于治疗抑郁症、焦虑症、双相障碍、注意力缺陷多动障碍（ADHD）、压力相关障碍、精神病性障碍如精神分裂症、神经系统疾病如帕金森病、神经退行性疾病如阿尔茨海默病、癫痫、偏头痛、高血压、物质滥用和代谢性疾病如进食障碍、糖尿病、糖尿病并发症、肥胖症、脂质代谢异常、能量消耗和吸收障碍、体温稳态的障碍和功能障碍、睡眠和昼夜节律障碍以及心血管疾病的治疗。