hex-3-yne-1,6-diyl diacetate | 85655-99-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: hex-3-yne-1,6-diyl diacetate
• 英文别名: 6-Acetyloxyhex-3-ynyl acetate
• CAS: 85655-99-8
• 化学式: C₁₀H₁₄O₄
• 分子量: 198.219
• InChiKey: TYPQOETYJPIDAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  hex-3-yne-1,6-diyl diacetate 、 二苯基乙炔 在 molibdenum carbonyl 对氯苯酚 作用下， 以 正辛烷 为溶剂， 反应 16.0h， 生成 4-苯基丁-3-炔-1-基乙酸酯
  参考文献：
  名称：

  Homogeneous metathesis of functionalised acetylenes

  摘要：

  DOI：

  10.1016/s0040-4039(00)85779-2
• 作为产物：
  描述：

  4-苯基丁-3-炔-1-基乙酸酯 在 molibdenum carbonyl 对氯苯酚 作用下， 以 正辛烷 为溶剂， 反应 4.5h， 生成 hex-3-yne-1,6-diyl diacetate
  参考文献：
  名称：

  Homogeneous metathesis of functionalised acetylenes

  摘要：

  DOI：

  10.1016/s0040-4039(00)85779-2

文献信息

• Ruthenium-Catalyzed Intermolecular Coupling of Vinylic 1,2-Bisboronates with Alkynes: Stereoselective Access to Boryl-Substituted Homoallylic Alcohols
  作者：Barry M. Trost、Guoting Zhang

  DOI：10.1021/jacs.0c01755

  日期：2020.4.22

  The ruthenium catalytic addition of alkenes to alkynes has been demonstrated as a powerful synthetic tool to form diene motifs and widely applied in the synthesis of complex molecules. How-ever, except for the intramolecular coupling, trisubstituted alkenes are unsatisfactory coupling partners with alkynes, presumably due to the increased steric hindrance. Herein, we discovered that the substituted

  烯烃与炔烃的钌催化加成已被证明是形成二烯基序的强大合成工具，并广泛应用于复杂分子的合成。然而，除了分子内偶联之外，三取代的烯烃与炔烃的偶联伙伴并不令人满意，这可能是由于空间位阻增加。在此，我们发现取代的 1,2-双硼酸乙烯酯衍生物可以作为三取代的烯烃等价物与炔烃偶联，通过与醛的顺序烯丙基硼化反应生成具有良好立体选择性的各种硼基取代的高烯丙醇基序。与双键上的碳取代基相反，硼取代基加速炔偶联。
• METHOD FOR PRODUCING TETRAFLUORO COMPOUND
  申请人：Miyashita Yasuhiro

  公开号：US20110178323A1

  公开（公告）日：2011-07-21

  Provided is a method for producing a tetrafluoro nitrogen-containing heterocyclic compound such as tetrafluoropyrrolidine in good yield and at low cost. The method comprises the steps of: (A) reacting a compound represented by the formula (I) with fluorine gas to produce a tetrafluoro compound represented by the formula (II), (B) converting the tetrafluoro derivative represented by the formula (II) to a compound represented by the formula (III), and (C) reacting the compound represented by the formula (III) with an amine compound represented by the formula NH 2 R 9 to produce a tetrafluoro nitrogen-containing heterocyclic compound represented by the formula (IV) or salt thereof.

  提供了一种生产四氟氮含杂环化合物（如四氟吡咯烷）的方法，产率高且成本低。该方法包括以下步骤：（A）将式（I）表示的化合物与氟气反应，生成式（II）表示的四氟化合物，（B）将式（II）表示的四氟衍生物转化为式（III）表示的化合物，以及（C）将式（III）表示的化合物与式NH2R9表示的胺化合物反应，生成式（IV）表示的四氟氮含杂环化合物或其盐。
• Nickel-catalyzed intermolecular carboiodination of alkynes with aryl iodides
  作者：Toshifumi Takahashi、Daiki Kuroda、Toru Kuwano、Yuji Yoshida、Takuya Kurahashi、Seijiro Matsubara

  DOI：10.1039/c8cc07560c

  日期：——

  Nickel-catalyzed intermolecular carboiodination of alkynes with aryl iodides to form highly substituted and functionalized alkenyl iodides has been developed. The reaction involves radical-mediated formal alkyne insertion into the carbon–nickel bond and carbon–iodine reductive elimination facilitated by Ni(III) species.

  已经开发了炔烃与芳基碘化物的镍催化的分子间碳碘化反应，以形成高度取代和官能化的烯基碘化物。该反应涉及自由基介导的正式炔烃插入到碳-镍键中，以及由Ni（III）物种促进的碳-碘还原消除。
• Homogeneous metathesis of functionalized alkynes
  作者：Mich�le Petit、Andr� Mortreux、Francis Petit

  DOI：10.1039/c39820001385

  日期：——

  Various functionalized disubstituted acetylenes, including esters, are prepared metathetically with high selectivity on molybdenum based homogeneous catalytic systems; this procedure is a useful tool for the synthesis of acetylenes, wnich can provide cis- or trans-olefins by further selective hydiogenation.

  在基于钼的均相催化体系上以高选择性对位制备了各种官能化的二取代乙炔，包括酯。该方法是合成乙炔的有用工具，wnich可以通过进一步的选择性加氢生成顺式或反式烯烃。
• Silanol–molybdenum hexacarbonyl as a new efficient catalyst for metathesis of functionalised alkynes under microwave irradiation
  作者：Didier Villemin、Michael Héroux、Virginie Blot

  DOI：10.1016/s0040-4039(01)00549-4

  日期：2001.5

  The catalytic mixture based on Mo(CO), was re-examined in the metathesis of 4-methoxytolan. Silanols (4) or (5) were found to be very active as co-catalysts. The metathesis of functional alkynes was convenient and rapidly achieved in octane as solvent under microwave irradiation in a resonance cavity. (C) 2001 Elsevier Science Ltd. All rights reserved.