1-[(2R,4R,5R)-5-ethyl-4-hydroxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione | 124685-21-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-[(2R,4R,5R)-5-ethyl-4-hydroxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione
• CAS: 124685-21-8
• 化学式: C₁₁H₁₆N₂O₄
• 分子量: 240.259
• InChiKey: BMEXKQSLDGAVNE-IWSPIJDZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  78.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3',4'-anhydrothymidine 、 甲基锂 生成 1-[(2R,4R,5R)-5-ethyl-4-hydroxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione
  参考文献：
  名称：

  TANAKA, HIROMICHI;FUKUI, MARIKO;HARAGUCHI, KAZUHIRO;MASAKI, MARIKO;MIYASA+, TETRAHEDRON LETT., 30,(1989) N9, C. 2567-2570

  摘要：

  DOI：

文献信息

• Purification Strategy for Direct Nucleophilic Procedures
  申请人：Cyr John

  公开号：US20110112293A1

  公开（公告）日：2011-05-12

  The present invention provides novel and advantageous processes for preparing and purifying chemical compounds such as pharmaceuticals. The processes comprise a nucleophilic substitution reaction with a moiety X wherein the leaving group L of a substrate S in the reaction is covalently attached to a purification moiety M. This concept offers a convenient and lime-saving way to purity the desired product S-X from non-reacted precursors S-L-M and by-products L-M.

  本发明提供了一种新颖和有利的制备和纯化化学化合物，如药物的方法。该方法包括使用一个官能团X进行亲核取代反应，其中反应底物S的离去基团L共价地连接到纯化官能团M上。这个概念提供了一种方便和节省时间的方法，以从未反应的前体S-L-M和副产物L-M中纯化所需的产品S-X。
• NON-POLAR AND POLAR LEAVING GROUPS
  申请人：Graham Keith

  公开号：US20120238740A1

  公开（公告）日：2012-09-20

  The present invention provides novel and advantageous processes for preparing and purifying pharmaceuticals The processes comprise a nucleophilic reaction wherein a modified leaving group L M , which has increased lipophilicity, of a vector in a nucleophilic reaction which offers a convenient and time-saving way to purify the product from non-reacted precursors vector-L M and by-products L M .

  本发明提供了制备和纯化药物的新型和有利的过程。该过程包括一种亲核反应，其中向量中的具有增加亲脂性的改性离去基LM在亲核反应中作为一个方便和节省时间的方式，从未反应的前体向量-LM和副产物LM中纯化产物。
• PHOTOCLEAVABLE LABELED NUCLEOTIDES AND NUCLEOSIDES AND METHODS FOR THEIR USE IN IN DNA SEQUENCING
  申请人：WU Weidong

  公开号：US20130072388A1

  公开（公告）日：2013-03-21

  Provided are novel nucleotides, nucleoside, and their derivatives described herein, that can be used in DNA sequencing technology and other types of DNA analysis. In one embodiment, the nucleotide or nucleoside with an unprotected 3′-OH group is derivatized at the nucleobase to include a fluorescent dye attached via a linker to a photocleavable terminating group. The photocleavable-fluorescent group is designed to terminate DNA synthesis as well as be cleaved so that DNA oligomers can be sequenced efficiently in a parallel format. The design of such rapidly cleavable fluorescent groups on nucleotides and nucleosides can enhance the speed and accuracy of sequencing of large oligomers of DNA in parallel, to allow rapid whole genome sequencing, and the identification of polymorphisms and other valuable genetic information, as well as allowing further manipulation and analysis of nucleic acid molecules in their native state following cleavage of the fluorescent group.

  本文介绍了新型核苷酸、核苷和其衍生物，可用于DNA测序技术和其他类型的DNA分析。在一个实施例中，未保护的3'-OH基团的核苷酸或核苷被衍生化，以在核碱基上包含通过连接剂连接到光解可断裂终止基团的荧光染料。光解可断裂的荧光基团被设计为终止DNA合成，并被裂解，以便在并行格式中高效地对DNA寡聚物进行测序。在核苷酸和核苷上设计这种快速可裂解的荧光基团，可以增强大型DNA寡聚物并行测序的速度和准确性，以实现快速的全基因组测序，并识别多态性和其他有价值的遗传信息，同时允许在裂解荧光基团后进一步操作和分析核酸分子的原生状态。
• CHIRAL CONTROL
  申请人：WAVE LIFE SCIENCES PTE. LTD.

  公开号：US20150211006A1

  公开（公告）日：2015-07-30

  The present invention relates to chirally controlled oligonucleotides, chirally controlled oligonucleotide compositions, and the method of making and using the same. The invention specifically encompasses the identification of the source of certain problems with prior methodologies for preparing chiral oligonucleotides, including problems that prohibit preparation of fully chirally controlled compositions, particularly compositions comprising a plurality of oligonucleotide types. In some embodiments, the present invention provides chirally controlled oligonucleotide compositions. In some embodiments, the present invention provides methods of making chirally controlled oligonucleotides and chirally controlled oligonucleotide compositions.

  本发明涉及手性控制的寡核苷酸、手性控制的寡核苷酸组合物以及其制备和使用方法。本发明特别涵盖了鉴定以前制备手性寡核苷酸方法中某些问题的来源，包括禁止制备完全手性控制的组合物，特别是包含多种寡核苷酸类型的组合物。在某些实施例中，本发明提供了手性控制的寡核苷酸组合物。在某些实施例中，本发明提供了制备手性控制的寡核苷酸和手性控制的寡核苷酸组合物的方法。
• Cleavage of a nucleosidic oxetane with carbanions: synthesis of a highly promising candidate for anti-HIV agents — a phosphonate isostere of AZT 5′-phosphate
  作者：Hiromichi Tanaka、Mariko Fukui、Kazuhiro Haraguchi、Mariko Masaki、Tadashi Miyasaka

  DOI：10.1016/s0040-4039(01)80452-4

  日期：1989.1