1,12-dodecanedial dioxime | 24435-12-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,12-dodecanedial dioxime
• 英文别名: 1,10-Decandicarboxaldehyd-dioxim；N-(12-hydroxyiminododecylidene)hydroxylamine
• CAS: 24435-12-9
• 化学式: C₁₂H₂₄N₂O₂
• 分子量: 228.335
• InChiKey: RLYRCCMYXQGMSX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  16
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  65.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,12-dodecanedial dioxime 在 吡啶 、 N-氯代丁二酰亚胺 、 sodium methylate 、 三乙胺 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 66.0h， 生成 bis-[1-(S)-β-D-glucopyranosyl] 1,12-dodecanebisthiohydroximate
  参考文献：
  名称：

  BIS-DESULFOGLUCOSINOLATES: A NEW CLASS OF BOLAFORMS

  摘要：

  Bis-desulfoglucosinolates 14-18 bearing D-gluco, lacto, malto and cellobio saccharidic moieties were synthesized in two steps from the corresponding protected 1-thio-beta-D-glycopyranoses 5, 8, 10 and 12 and bis-hydroximoyl chlorides 3a and 4a derived from 1,8-octanedial (1) and 1,12-dodecanedial (2). Fully deprotections of the intermediate O-acetylated derivatives 6, 7, 9, 11 and 13 were realized either using Zemplen method or methanol/triethylamine/water mixture, the choice of the conditions being dependent on the solubility in methanol of the fully and partially acetylated derivatives.

  DOI：

  10.1081/scc-120012980
• 作为产物：
  描述：

  十二烷二醛 在 盐酸羟胺 、 sodium acetate 作用下， 以 乙醇 、 水 为溶剂， 反应 3.0h， 以84%的产率得到1,12-dodecanedial dioxime
  参考文献：
  名称：

  BIS-DESULFOGLUCOSINOLATES: A NEW CLASS OF BOLAFORMS

  摘要：

  Bis-desulfoglucosinolates 14-18 bearing D-gluco, lacto, malto and cellobio saccharidic moieties were synthesized in two steps from the corresponding protected 1-thio-beta-D-glycopyranoses 5, 8, 10 and 12 and bis-hydroximoyl chlorides 3a and 4a derived from 1,8-octanedial (1) and 1,12-dodecanedial (2). Fully deprotections of the intermediate O-acetylated derivatives 6, 7, 9, 11 and 13 were realized either using Zemplen method or methanol/triethylamine/water mixture, the choice of the conditions being dependent on the solubility in methanol of the fully and partially acetylated derivatives.

  DOI：

  10.1081/scc-120012980