benzyl N-tert-butyloxycarbonyl-L-γ-glutamate α-N,N-dimethylamide | 841233-80-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: benzyl N-tert-butyloxycarbonyl-L-γ-glutamate α-N,N-dimethylamide
• CAS: 841233-80-5
• 化学式: C₁₉H₂₈N₂O₅
• 分子量: 364.442
• InChiKey: NEJSEUWIZKPGFF-HNNXBMFYSA-N

物化性质

• 沸点：
  517.3±50.0 °C(Predicted)
• 密度：
  1.123±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.49
• 重原子数：
  26.0
• 可旋转键数：
  7.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  84.94
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  benzyl N-tert-butyloxycarbonyl-L-γ-glutamate α-N,N-dimethylamide 、 三氟乙酸 以 二氯甲烷 为溶剂， 以0.98 g的产率得到benzyl L-γ-glutamate α-N,N-dimethylamide trifluoroacetic acid salt
  参考文献：
  名称：

  Synthesis and neuroprotective activity of analogues of glycyl-l-prolyl-l-glutamic acid (GPE) modified at the α-carboxylic acid

  摘要：

  The synthesis of nine GPE* analogues, wherein the alpha-carboxylic acid group of glutamic acid has been modified, is described by coupling readily accessible N-benzyloxycarbonyl-glycyl-L-proline 2 with various analogues of glutamic acid. Pharmacological evaluation of the novel compounds was undertaken to further understand the role of the glutamate residue on the observed neuroprotective properties of the endogenous tripeptide GPE. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.10.005
• 作为产物：
  描述：

  N-叔丁氧羰基-L-谷氨酸 5-苄酯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 20.75h， 生成 benzyl N-tert-butyloxycarbonyl-L-γ-glutamate α-N,N-dimethylamide
  参考文献：
  名称：

  Synthesis and neuroprotective activity of analogues of glycyl-l-prolyl-l-glutamic acid (GPE) modified at the α-carboxylic acid

  摘要：

  The synthesis of nine GPE* analogues, wherein the alpha-carboxylic acid group of glutamic acid has been modified, is described by coupling readily accessible N-benzyloxycarbonyl-glycyl-L-proline 2 with various analogues of glutamic acid. Pharmacological evaluation of the novel compounds was undertaken to further understand the role of the glutamate residue on the observed neuroprotective properties of the endogenous tripeptide GPE. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.10.005