2-butyl-2-methylsuccinic acid | 90647-77-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-butyl-2-methylsuccinic acid
• 英文别名: 2-butyl-2-methyl-succinic acid；2-Butyl-2-methyl-bernsteinsaeure；2-Butyl-2-methylbutanedioic acid
• CAS: 90647-77-1
• 化学式: C₉H₁₆O₄
• 分子量: 188.224
• InChiKey: WMCFQEMLVVLZIJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-butyl-2-methylsuccinic acid 在 氨 、 水 作用下， 生成 3-butyl-3-methyl-pyrrolidine-2,5-dione
  参考文献：
  名称：

  Anticonvulsants. III. A Study of N,α,β-Alkylsuccinimides

  摘要：

  DOI：

  10.1021/ja01098a034
• 作为产物：
  描述：

  2,3-dicyano-3-methyl-heptanoic acid ethyl ester 在 盐酸 作用下， 生成 2-butyl-2-methylsuccinic acid
  参考文献：
  名称：

  Anticonvulsants. III. A Study of N,α,β-Alkylsuccinimides

  摘要：

  DOI：

  10.1021/ja01098a034

文献信息

• Novel succinate compounds, compositions and methods of use and preparation
  申请人：——

  公开号：US20020115863A1

  公开（公告）日：2002-08-22

  Novel hydroxamic acid compounds are disclosed. These hydroxamates inhibit peptidyl deformylase (PDF), an enzyme present in prokaryotes. The hydroxymates are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as matrix metalloproteinases (MMPs). Methods of synthesis and of use of the compounds are also disclosed.

  揭示了一种新型羟羧酸化合物。这些羟羧酸酯抑制肽变形酶（PDF），这是一种存在于原核生物中的酶。这些羟羧酸酯可用作抗微生物和抗生素。该发明的化合物表现出对肽变形酶的选择性抑制，而不影响其他金属蛋白酶如基质金属蛋白酶（MMPs）。该文还揭示了这些化合物的合成方法和使用方法。
• [EN] NOVEL SUCCINATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE AND PREPARATION<br/>[FR] NOUVEAUX COMPOSES A BASE DE SUCCINATE, COMPOSITIONS LES CONTENANT, ET PROCEDES D'UTILISATION ET DE PREPARATION DE CEUX-CI
  申请人：VERSICOR INC

  公开号：WO2001044179A1

  公开（公告）日：2001-06-21

  Novel hydroxamic acid compounds of Formula (I) are disclosed. These hydroxamates inhibit peptide deformylase (PDF), an enzyme present in prokaryotes. The hydroxymates are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as matrix metalloproteinases (MMPs). Methods of synthesis and of use of the compounds are also disclosed.

  本发明揭示了式（I）的新型羟肟酸化合物。这些羟肟酸盐抑制肽变形酶（PDF），一种存在于原核生物中的酶。这些羟肟酸盐可用作抗微生物和抗生素。本发明的化合物显示出对肽酰变形酶的选择性抑制，而不是其他金属蛋白酶如基质金属蛋白酶（MMPs）。本发明还揭示了这些化合物的合成和使用方法。
• Flame retardants with high halogen content and low viscosity
  申请人：Albemarle Corporation

  公开号：EP2107079A2

  公开（公告）日：2009-10-07

  A flame retardant formulation which is the combination of at least (1) at least one bromine-containing polyol flame retardant formed from the reaction of (a) tetrabromophthalic anhydride, (b) an aliphatic polyol, and (c) an epoxide, and (2) at least one aliphatic diester of an alkane dicarboxylic acid, with the proviso that the formulation has a viscosity at 25°C of about 20,000 cps or less, and a bromine content of at least about 40 wt%. A flame retardant compound formed from A) tetrabromophthalic anhydride; B) diethylene glycol; C) at least one alpha-omega alkane diol, or at least one alpha-omega alkane diol and at least one aliphatic monool; and D) at least one alkylene oxide; with the proviso that the compound has a viscosity at 25°C of about 60,000 cps or less, and a bromine content of at least about 43 wt%. Polymer compositions formed from (a) a polyurethane or a polyisocyanurate and (b) a formulation of the invention. One process to make a formulation involves heating a mixture of (a), (b), and at least one liquid aliphatic diester of a alkane dicarboxylic acid to form an intermediate composition; and then the intermediate is contacted one or more times with (c) thereby producing the formulation. Optionally, excess (c) is removed.

  一种阻燃剂配方，它至少是以下物质的组合：(1)至少一种含溴多元醇阻燃剂，由(a)四溴邻苯二甲酸酐、(b)脂肪族多元醇和(c)环氧化物反应生成；(2)至少一种烷烃二羧酸脂肪族二酯，但该配方在 25°C 时的粘度约为 20°C、(2) 烷烃二羧酸的至少一种脂肪族二酯，但该制剂在 25°C 时的粘度不超过约 20,000 cps，溴含量不低于约 40 wt%。由以下物质形成的阻燃化合物：A) 四溴邻苯二甲酸酐；B) 二甘醇；C) 至少一种α-ω-烷二醇，或至少一种α-ω-烷二醇和至少一种脂族一元醇；以及 D) 至少一种环氧亚烷烃；但条件是该化合物在 25°C 时的粘度约为 60,000 cps 或更低，溴含量至少约为 43 wt%。由(a)聚氨酯或聚异氰脲酸酯和(b)本发明配方形成的聚合物组合物。制备配方的一种工艺包括加热(a)、(b)和至少一种烷烃二羧酸的液态脂肪族二酯类的混合物，以形成中间体组合物；然后将中间体与(c)接触一次或多次，从而制得配方。可选择去除多余的 (c)。
• Nielsen et al., Acta Chemica Scandinavica (1947), 1959, vol. 13, p. 1943,1951
  作者：Nielsen et al.

  DOI：——

  日期：——
• Design, synthesis, and anticonvulsant activity of N-phenylamino derivatives of 3,3-dialkyl-pyrrolidine-2,5-diones and hexahydro-isoindole-1,3-diones
  作者：Krzysztof Kamiński、Jolanta Obniska

  DOI：10.1016/j.bmc.2008.03.037

  日期：2008.5

  In the present study on the development of new anticonvulsants, the library of differently substituted N-phenylamino pyrrolidine2,5-dione and hexahydro-isoindole-1,3-dione derivatives was synthesized. The anticonvulsant activity of all the compounds was evaluated using the maximal electroshock (MES) and pentylenetetrazole (scPTZ) screens, which are the most widely employed seizure models for early identification of candidate anticonvulsants. Their neurotoxicity was determined applying the rotorod test. The pharmacological results revealed that the majority of compounds were effective in electrical (MES) and/or pentylenetetrazole induced seizure (scPTZ) models. The quantitative in vivo anticonvulsant evaluation of N-phenylamino-3,3-dimethyl-pyrrolidine-2,5-dione (15), conducted at the time of peak pharmacodynamic activity (TPE), showed the MES ED50 value of 69.89 mg/ kg in rats. The median toxic dose (TD50) was 500 mg/ kg, providing compound 15 with a protective index (TD50/ED50) of 7.15 in the MES test. (c) 2008 Elsevier Ltd. All rights reserved.