申请人:ENZO BIOCHEM, INC.
公开号:EP0916737A2
公开(公告)日:1999-05-19
Described is a polynucleotide compound comprising a polynucleotide which comprises at least one entity which upon hybridization to a complementary polynucleotide is capable of generating a detectable change in property in said hybrid, said entity being covalently or non-covalently attached by means of a linker arm to the base moiety, sugar moiety or phosphate moiety of a nucleotide in said polynucleotide, which polynucleotide compound may be used for detecting the presence of a target polynucleotide or for preventing the transcription or translation of a target polynucleotide.
所述的多核苷酸化合物包含一种多核苷酸,该多核苷酸包含至少一个实体,该实体与互补多核苷酸杂交后能够在所述杂交体中产生可检测的性质变化,所述实体通过连接臂与碱基分子共价或非共价连接、多核苷酸化合物可用于检测目标多核苷酸的存在或阻止目标多核苷酸的转录或翻译。