2-Phenoxy-propanol-methansulfonylester | 61687-10-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-Phenoxy-propanol-methansulfonylester
• 英文别名: 2-phenoxy-1-propanol O-methanesulfonate；2-Phenoxypropyl methanesulfonate
• CAS: 61687-10-3
• 化学式: C₁₀H₁₄O₄S
• 分子量: 230.285
• InChiKey: OMCLFGKJUXKWRU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  61
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-Phenoxy-propanol-methansulfonylester 生成 2-Phenoxy-propyliodid
  参考文献：
  名称：

  COLLETT A.; JACQUES J., J. CHEM. SOC. CHEM. COMMUNS , 1976, NO 18, 708-709

  摘要：

  DOI：
• 作为产物：
  描述：

  2-苯氧基丙醇 、 甲基磺酰氯 在 盐酸 、 三乙胺 作用下， 以 (2S)-N-methyl-1-phenylpropan-2-amine hydrate 、 二氯甲烷 为溶剂， 生成 2-Phenoxy-propanol-methansulfonylester
  参考文献：
  名称：

  Method of treating lipidemia with aryloxyalkylaminobenzoic acids and

  摘要：

  芳氧烷基氨基苯甲酸和酯作为降脂化合物。

  公开号：

  US04182776A1

文献信息

• Beta-carbolines as growth hormone secretagogue receptor (GHSR) antagonists
  申请人：Crossley Roger

  公开号：US20050288316A1

  公开（公告）日：2005-12-29

  The present invention relates to compounds of Formula (I): wherein R 3 -R 8 , X, and Y are as described herein, processes for preparing the compounds, pharmaceutical compositions comprising the compounds, and use of the compounds and compositions in the prophylaxis or treatment of a GHSR receptor-related disorder. Examples of such disorders are obesity and related disorders such as diabetes type II, dyslipidemia and the metabolic syndrome Prader-Willi syndrome, cardiovascular diseases such as atherosclerotic vascular disease, angina pectoris, myocardial infarction and stroke, acromegaly and cancer, in particular breast, lung, prostate, thyroid and endocrine pituary carcinomas.

  本发明涉及式（I）的化合物：其中R3-R8，X和Y如本文所述，制备该化合物的方法，包含该化合物的药物组合物，以及在预防或治疗与GHSR受体相关的疾病中使用该化合物和组合物。此类疾病的例子包括肥胖症和相关疾病，如2型糖尿病，血脂异常和代谢综合征，普拉德-威利综合征，心血管疾病，如动脉粥样硬化、心绞痛、心肌梗死和中风，肢端肥大症和癌症，特别是乳腺癌、肺癌、前列腺癌、甲状腺癌和内分泌腺垂体癌。
• [EN] NOVEL BETA-CARBOLINES AS GROWTH HORMONE SECRETAGOGUE RECEPTOR (GHSR) ANTAGONISTS<br/>[FR] NOUVELLES CARBOLINES-BETA EN TANT QU'ANTAGONISTES DE RECEPTEUR DE SECRETAGOGUE D'HORMONE DE CROISSANCE
  申请人：BIOVITRUM AB

  公开号：WO2005048916A2

  公开（公告）日：2005-06-02

  The present invention relates to compounds of Formula (I): Formula (I) wherein R3-R8, X, and Y are as described herein, processes for preparing the compounds, pharmaceutical compositions comprising the compounds, and use of the compounds and compositions in the prophylaxis or treatment of a GHSR receptor-related disorder. Examples of such disorders are obesity and related disorders such as diabetes type II, dyslipidemia and the metabolic syndrome Prader-Willi syndrome, cardiovascular diseases such as atherosclerotic vascular disease, angina pectoris, myocardial infarction and stroke, acromegaly and cancer, in particular breast, lung, prostate, thyroid and endocrine pituary carcinomas.
• [EN] PYRIDIN-3-YL ACETIC ACID DERIVATIVES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION<br/>[FR] DÉRIVÉS D'ACIDE PYRIDIN-3-YL-ACÉTIQUE EN TANT QU'INHIBITEURS DE LA RÉPLICATION DU VIRUS DE L'IMMUNODÉFICIENCE HUMAINE
  申请人：VIIV HEALTHCARE UK NO 5 LTD

  公开号：WO2019244066A2

  公开（公告）日：2019-12-26

  Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infected with HIV or AIDS.