(2S)-1-(4-chlorophenoxy)-3-(propan-2-ylamino)propan-2-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (2S)-1-(4-chlorophenoxy)-3-(propan-2-ylamino)propan-2-ol
• 化学式: C₁₂H₁₈ClNO₂
• 分子量: 243.733
• InChiKey: JHNLCWKHEYGEHY-NSHDSACASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  41.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-氯苯基缩水甘油醚 、 异丙胺 生成 (2S)-1-(4-chlorophenoxy)-3-(propan-2-ylamino)propan-2-ol
  参考文献：
  名称：

  Kamal Ahmed, Damayanthi Yalamati, Rao Maddamsetty V., Tetrahedron: Asymmetry, 3 (1992) N 11, S 1361-1364

  摘要：

  DOI：

文献信息

• Dynamic kinetic asymmetric synthesis of β-aminoalcohols from racemic epoxides in cyclodextrin complexes under solid state conditions
  作者：L. Rajender Reddy、N. Bhanumathi、K. Rama Rao

  DOI：10.1039/b004643o

  日期：——

  It has been shown for the first time that enantiopure β-aminoalcohols can be prepared from racemic epoxides by dynamic kinetic resolution involving enantio-differentiating racemisation in cyclodextrin complexes under solid state conditions.

  研究首次证明，在固态条件下，通过环糊精络合物中的对映体分化消旋化动态动力学解析，可从外消旋环氧化物制备出对映体纯δ-氨基丙醇。
• Enantioselective ring opening of epoxides with trimethylsilyl azide (TMSN3) in the presence of β-cyclodextrin: an efficient route to 1,2-azido alcohols
  作者：Ahmed Kamal、M Arifuddin、Maddamsetty V Rao

  DOI：10.1016/s0957-4166(99)00464-4

  日期：1999.11

  The ring opening of epoxides with nucleophiles such as TMSN3 and isopropylamine takes place enantioselectively in the presence of (beta-cyclodextrin under extremely mild conditions and the azido alcohols and amino alcohols are formed as (S)-isomers. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.
• Enzyme catalyzed stereoselective synthesis of (S)-propanolamines
  作者：Ahmed Kamal、Maddamsetty V Rao

  DOI：10.1016/s0957-4166(00)86256-4

  日期：1994.10

  Stereoselective synthesis of (S)-propanolamines has been carried out by the ring opening of racemic epoxides with 2-propylamine in presence of lipases and subtilisin. The effect of solvent towards selectivity has also been studied.
• Stereoselective synthesis of (S)-propanol amines: Lipase catalyzed opening of epoxides with 2-propylamine
  作者：Ahmed Kamal、Yalamati Damayanthi、Maddamsetty V. Rao

  DOI：10.1016/0957-4166(92)80006-i

  日期：1992.11

  The ring opening of epoxides with 2-propylamine in presence of lipase in organic solvents affords selectively (S)-propanol amines. The effect of solvents towards selectivity has also been examined.