bis-(2-levulinoyloxy-ethyl)-ether | 67385-17-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: bis-(2-levulinoyloxy-ethyl)-ether
• 英文别名: Bis-(2-laevulinoyloxy-aethyl)-aether；2-{2-[(4-Oxopentanoyl)oxy]ethoxy}ethyl 4-oxopentanoate；2-[2-(4-oxopentanoyloxy)ethoxy]ethyl 4-oxopentanoate
• CAS: 67385-17-5
• 化学式: C₁₄H₂₂O₇
• 分子量: 302.324
• InChiKey: QTEIOSRWLKCFRC-UHFFFAOYSA-N

物化性质

• 沸点：
  209-216 °C
• 密度：
  1.131±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  21
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  96
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  乙酰丙酸 、 二乙二醇 在 硫酸 、 甲苯 作用下， 生成 bis-(2-levulinoyloxy-ethyl)-ether
  参考文献：
  名称：

  Hachihama; Hayashi, Kogyo Kagaku zasshi / Journal of the Society of Chemical Industry, 1951, vol. 54, p. 695,696

  摘要：

  DOI：

文献信息

• [EN] POLYHYDROXY KETAL ESTER ADDUCTS, METHODS OF MANUFACTURE AND USES THEREOF<br/>[FR] ADDUITS DE POLYHYDROXY CÉTAL ESTER, LEURS PROCÉDÉS DE FABRICATION ET LEURS UTILISATIONS
  申请人：SEGETIS INC

  公开号：WO2012065116A3

  公开（公告）日：2012-09-07
• Polyvinyl composition and method of making same
  申请人：GEN TIRE &

  公开号：US02654723A1

  公开（公告）日：1953-10-06
• POLYHYDROXY KETAL ESTER ADDUCTS, METHODS OF MANUFACTURE AND USES THEREOF
  申请人：Mullen Brian D.

  公开号：US20120121911A1

  公开（公告）日：2012-05-17

  Disclosed herein is a polyhydroxy ketal adduct obtained by the esterification of a hydrocarbon polyol by at least 1.5 equivalents of a ketocarboxy to produce an intermediate ketocarboxylic ester. The intermediate polyketocarboxylic ester is then ketalized to produce the polyhydroxyketal adduct, which can be used to provide a polymeric composition.
• WATERBORNE COMPOSITIONS
  申请人：DAINES Alison Margaret

  公开号：US20160237302A1

  公开（公告）日：2016-08-18

  The present invention provides for compositions comprising at least one polyketone; and at least one acyl hydrazide; wherein, the polyketone comprises at least two levulinic acid moieties. The present inventions also provide for novel polyhydrazone compounds. Examples of completely water-soluble compositions comprising acyl hydrazide and polyketone that form polyhydrazones compounds are provided herein. The compositions and polyhydrazones of the present invention are useful in the preparation of coating materials and the formation of films.
• Hydrogel-Linked IL-1ra Prodrug
  申请人：ASCENDIS PHARMA OSTEOARTHRITIS DIVISION A/S

  公开号：US20180042996A1

  公开（公告）日：2018-02-15

  The present invention relates to a hydrogel-linked IL-Ira prodrug or pharmaceutically acceptable salt thereof. It further relates to a pharmaceutical composition comprising said hydrogel-linked IL-Ira prodrug, its use as medicament for the treatment of a IL-1 mediated disease, ways of application of such hydrogel-linked IL-Ira prodrugs or pharmaceutical compositions, and containers comprising the hydrogel-linked IL-Ira prodrugs or pharmaceutically acceptable salt thereof or a pharmaceutical composition comprising said hydrogel-linked IL-Ira prodrug or pharmaceutically acceptable salt thereof.