1,4-Dimethoxy-2,3-dimethyl-5-hydroxymethylbenzene | 107446-94-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,4-Dimethoxy-2,3-dimethyl-5-hydroxymethylbenzene
• 英文别名: (2,5-dimethoxy-3,4-dimethylphenyl)methanol
• CAS: 107446-94-6
• 化学式: C₁₁H₁₆O₃
• 分子量: 196.246
• InChiKey: MOHUXWSCJQRVIY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,4-Dimethoxy-2,3-dimethyl-5-hydroxymethylbenzene 在 氯化亚砜 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 生成 1-氯甲基-2,5-二甲氧基-3,4-二甲基-苯
  参考文献：
  名称：

  Radical reactions leading to substituted coumarins

  摘要：

  The reaction of 4-hydroxycoumarins with a series of quinonic chlorides under photostimulation was shown to provide an efficient approach to 3-alkylated coumarin derivatives, Alkylation reactions of this type proceeded via an electron transfer mechanism (S(RN)1). (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00777-7
• 作为产物：
  描述：

  2,5-dimethoxy-3,4-dimethylbenzaldehyde 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 3.0h， 生成 1,4-Dimethoxy-2,3-dimethyl-5-hydroxymethylbenzene
  参考文献：
  名称：

  Radical reactions leading to substituted coumarins

  摘要：

  The reaction of 4-hydroxycoumarins with a series of quinonic chlorides under photostimulation was shown to provide an efficient approach to 3-alkylated coumarin derivatives, Alkylation reactions of this type proceeded via an electron transfer mechanism (S(RN)1). (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00777-7
• 作为试剂：
  描述：

  2,5-二甲氧基-3,4-二甲基苯甲醇乙酸酯 、 在 1,4-Dimethoxy-2,3-dimethyl-5-hydroxymethylbenzene 作用下， 以 甲醇 、 sodium hydroxide 为溶剂， 反应 1.0h， 以to give 1.8 g of 1,4-dimethoxy-2,3-dimethyl-5-hydroxymethylbenzene (intermediate E)的产率得到1,4-Dimethoxy-2,3-dimethyl-5-hydroxymethylbenzene
  参考文献：
  名称：

  Use of substituted quinone electron transfer agents in analytical

  摘要：

  某些取代苯并和萘醌电子转移剂在分析组成物、元素和方法中是有用的，例如用于测定活细胞。这些电子转移剂能够被分析物还原，而还原的电子转移剂又进一步还原另一种化合物，提供可检测的物种（例如染料）。这种发明中有用的电子转移剂的还原电位（E.sub.1/2）在pH 7的水溶液缓冲溶液中的范围为约-320至约+400 mV。

  公开号：

  US04746607A1

文献信息

• Use of substituted quinone electron transfer agents in analytical determinations
  申请人：EASTMAN KODAK COMPANY (a New Jersey corporation)

  公开号：EP0190740A2

  公开（公告）日：1986-08-13

  Certain substituted benzo- and naphthoquinone electron transfer agents are useful in analytical compositions, elements and methods, e.g. for determinations of living cells. These electron transfer agents are capable of being reduced by an analyte, and the reduced electron transfer agent, in turn, reduces another compound providing a detectable species (e.g. a dye). The reduction potential (E1/2) of the electron transfer agents useful in this invention is in the range of from -320 to +400 mV as measured in an aqueous buffer solution at pH 7.

  某些取代的苯醌和萘醌电子转移剂可用于分析组合物、元素和方法中，例如用于测定活细胞。这些电子转移剂能够被分析物还原，被还原的电子转移剂反过来会还原另一种化合物，从而提供可检测的物质（如染料）。本发明中电子转移剂的还原电位（E1/2）在 pH 值为 7 的缓冲水溶液中的测量范围为 -320 至 +400 mV。
• US4746607A
  申请人：——

  公开号：US4746607A

  公开（公告）日：1988-05-24
• [EN] NEW DRUG DELIVERY SYSTEM FOR CROSSING THE BLOOD BRAIN BARRIER<br/>[FR] NOUVEAU DISPOSITIF D'ADMINISTRATION DE MÉDICAMENT POUR TRAVERSER LA BARRIÈRE HÉMATOMÉNINGÉE
  申请人：UNIV CALIFORNIA

  公开号：WO2007095631A2

  公开（公告）日：2007-08-23

  [EN] New ubiquinol analogs are disclosed, as well as methods of using these compounds to deliver drug moieties to the body.
  [FR] L'invention concerne de nouveaux analogues de l'ubiquinol, ainsi que des méthodes pour utiliser ces composés afin d'administrer des fractions de médicament au corps.
• Radical reactions leading to substituted coumarins
  作者：Anne Giraud、Patrice Vanelle、Luc Giraud

  DOI：10.1016/s0040-4039(99)00777-7

  日期：1999.6

  The reaction of 4-hydroxycoumarins with a series of quinonic chlorides under photostimulation was shown to provide an efficient approach to 3-alkylated coumarin derivatives, Alkylation reactions of this type proceeded via an electron transfer mechanism (S(RN)1). (C) 1999 Published by Elsevier Science Ltd. All rights reserved.
• Use of substituted quinone electron transfer agents in analytical
  申请人：Eastman Kodak Company

  公开号：US04746607A1

  公开（公告）日：1988-05-24

  Certain substituted benzo- and naphthoquinone electron transfer agents are useful in analytical compositions, elements and methods, e.g. for determinations of living cells. These electron transfer agents are capable of being reduced by an analyte, and the reduced electron transfer agent, in turn, reduces another compound providing a detectable species (e.g. a dye). The reduction potential (E.sub.1/2) of the electron transfer agents useful inthis invention is in the range of from about -320 to about +400 mV as measured in an aqueous buffer solution at pH 7.

  某些取代苯并和萘醌电子转移剂在分析组成物、元素和方法中是有用的，例如用于测定活细胞。这些电子转移剂能够被分析物还原，而还原的电子转移剂又进一步还原另一种化合物，提供可检测的物种（例如染料）。这种发明中有用的电子转移剂的还原电位（E.sub.1/2）在pH 7的水溶液缓冲溶液中的范围为约-320至约+400 mV。