(3S,4E)-4-[2-[(4aR,6aS,7R,10aS,10bR)-Decahydro-3,3,6a,10b-tetramethyl-8-methylene-1H-naphtho[2,1-d][1,3]dioxin-7-yl]ethylidene]tetrahydro-5-oxo-3-furanyl dodecanoate | 1239575-59-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (3S,4E)-4-[2-[(4aR,6aS,7R,10aS,10bR)-Decahydro-3,3,6a,10b-tetramethyl-8-methylene-1H-naphtho[2,1-d][1,3]dioxin-7-yl]ethylidene]tetrahydro-5-oxo-3-furanyl dodecanoate
• 英文别名: [(3S,4E)-4-[2-[(4aR,6aS,7R,10aS,10bR)-3,3,6a,10b-tetramethyl-8-methylidene-1,4a,5,6,7,9,10,10a-octahydronaphtho[2,1-d][1,3]dioxin-7-yl]ethylidene]-5-oxooxolan-3-yl] dodecanoate
• CAS: 1239575-59-7
• 化学式: C₃₅H₅₆O₆
• 分子量: 572.826
• InChiKey: DTUFTMJWJQZURK-WHOWCVLFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.9
• 重原子数：
  41
• 可旋转键数：
  14
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (3S,4E)-4-[2-[(4aR,6aS,7R,10aS,10bR)-Decahydro-3,3,6a,10b-tetramethyl-8-methylene-1H-naphtho[2,1-d][1,3]dioxin-7-yl]ethylidene]tetrahydro-5-oxo-3-furanyl dodecanoate 在 水 、 溶剂黄146 作用下， 反应 0.5h， 以38.7%的产率得到andrographolide-14-laurate
  参考文献：
  名称：

  Design, synthesis and antibacterial activity of novel andrographolide derivatives

  摘要：

  A series of andrographolide derivatives were synthesized through a facile condensation reaction with different carboxylic acids. The new compounds were characterized and screened for their antibacterial activities. A number of the new compounds significantly reduced bacterial quorum sensing virulence factors production in Pseudomonas aeruginosa, essential for pathogenesis. Compound 11b showed the best activity among all the new compounds. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.04.094
• 作为产物：
  描述：

  ethyl dodecanoyl carbonate 、 3,18-O-isopropylideneandrographolide 以 二氯甲烷 为溶剂， 反应 18.0h， 以51.2%的产率得到(3S,4E)-4-[2-[(4aR,6aS,7R,10aS,10bR)-Decahydro-3,3,6a,10b-tetramethyl-8-methylene-1H-naphtho[2,1-d][1,3]dioxin-7-yl]ethylidene]tetrahydro-5-oxo-3-furanyl dodecanoate
  参考文献：
  名称：

  Design, synthesis and antibacterial activity of novel andrographolide derivatives

  摘要：

  A series of andrographolide derivatives were synthesized through a facile condensation reaction with different carboxylic acids. The new compounds were characterized and screened for their antibacterial activities. A number of the new compounds significantly reduced bacterial quorum sensing virulence factors production in Pseudomonas aeruginosa, essential for pathogenesis. Compound 11b showed the best activity among all the new compounds. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.04.094

文献信息

• Design, synthesis and antibacterial activity of novel andrographolide derivatives
  作者：Zhongli Wang、Pei Yu、Gaoxiao Zhang、Lipeng Xu、Dingyuan Wang、Liang Wang、Xiangping Zeng、Yuqiang Wang

  DOI：10.1016/j.bmc.2010.04.094

  日期：2010.6.15

  A series of andrographolide derivatives were synthesized through a facile condensation reaction with different carboxylic acids. The new compounds were characterized and screened for their antibacterial activities. A number of the new compounds significantly reduced bacterial quorum sensing virulence factors production in Pseudomonas aeruginosa, essential for pathogenesis. Compound 11b showed the best activity among all the new compounds. (C) 2010 Elsevier Ltd. All rights reserved.