(2S)-2-氨基-2-[(1S)-2-亚甲基环丙基]乙酸 | 2517-07-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: (2S)-2-氨基-2-[(1S)-2-亚甲基环丙基]乙酸
• 英文名称: (2-methylenecyclopropyl)glycine
• 英文别名: methylenecyclopropylglycine；MCPG；α-Methylencyclopropylglycin；2-Azaniumyl-2-(2-methylidenecyclopropyl)acetate
• CAS: 2517-07-9
• 化学式: C₆H₉NO₂
• mdl: MFCD19206775
• 分子量: 127.143
• InChiKey: MPIZVHPMGFWKMJ-UHFFFAOYSA-N

物化性质

• 熔点：
  246 °C (decomp)
• 沸点：
  256.4±23.0 °C(Predicted)
• 密度：
  1.22±0.1 g/cm3(Predicted)
• 溶解度：
  可溶于氯仿（少许）、DMSO（少许）、水（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  -2.8
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2922499990

反应信息

• 作为产物：
  描述：

  5-(2-亚甲基环丙基)-2,4-咪唑烷二酮 在 barium dihydroxide 作用下， 反应 72.0h， 以38%的产率得到(2S)-2-氨基-2-[(1S)-2-亚甲基环丙基]乙酸
  参考文献：
  名称：

  Synthesis of (±)-(2-Methylenecyclopropyl)glycine and (±)-4-[(Amino(carboxymethyl)]spiro[2.2]pentane-1-carboxylic Acid

  摘要：

  本文介绍了一种制备外消旋环丙基甘氨酸的简便方法，包括先氧化环丙基甲醇，然后进行布歇勒-伯格反应，并依次水解得到的海因。

  DOI：

  10.1055/s-2006-926320

文献信息

• GLYCERO-COMPOUND HAVING TRIPLE BOND AND MEMBRANE MATERIAL CONTAINING THE SAME
  申请人：BABA Teruhiko

  公开号：US20070105823A1

  公开（公告）日：2007-05-10

  The present invention provides a chemically stable and novel glycero-compound having one or two triple bonds, one molecule of a glycerol and one or two molecules of a fatty alcohol having a triple bond being linked through an ether bond, an organic group being linked to residual hydroxyl groups of the glycerol, which can be used as a membrane material for forming a vesicle membrane due to its high intermolecular cohesive force, and also provides a membrane forming material containing the same. The glycero-compound has a triple bond represented by the following general formula (1): wherein n and m each represents a number of 1 to 17 and the total (n+m) is a number of 4 to 18, n and m may be the same or different, and R represents a hydrogen atom, a metal atom, a phosphoric acid group, or an organic group which may be linked through a phosphoric acid group.

  本发明提供了一种化学稳定且新颖的甘油化合物，其中含有一个或两个三键，一个甘油分子和一个或两个含有三键的脂肪醇分子通过醚键连接，有机基与甘油的残余羟基连接，由于其高分子间内聚力可用作形成囊泡膜的膜材料，还提供了含有相同物质的膜形成材料。该甘油化合物具有以下一般式（1）所代表的三键：其中n和m分别表示1到17之间的数字，总数（n+m）为4到18之间的数字，n和m可以相同也可以不同，R表示氢原子、金属原子、磷酸基或可以通过磷酸基连接的有机基。
• NMR imaging with Mn(II) coordination compositions
  申请人：SALUTAR, INC.

  公开号：EP0308983A2

  公开（公告）日：1989-03-29

  Enhanced T₁ and T₂ relaxation in NMRI is obtained with solutions of non-chelate coordination compounds of the formula: [Mn(II)(H₂O)mA1nA2oA3pA4q]+a(Y,Zr)-a In the formula, A1, A2, A3 and A4 are the same of different amino-substituted carboxylic acid groups having from 2 to 18 carbons; Y and Z are each the same or a different anion of a pharmaceutically acceptable inorganic acid or an organic carboxylic acid having from 2 to 18 carbons; a is valence of the ions; m, n, o, p, and q are each 1 or 0, (m + n + o + p + q) = 4, and (n + o + p + q) is preferably from 1 to 3; and r is 1, and if Y is a multivalent anion, r is 0 or 1. The solution has a pH within the range of from 4 to 9.5, preferably from 5 to 7, and optimally from 5 to 6.5, and for parenteral administration, a coordination compound concentration of from 0.5 to 4.0 wt%. Preferably, n is from 1 to 3, optimally from 2-4, and most optimally from 2 to 3, and Y and Z are monovalent. For example Y is preferably an anion of an aliphatic carboxylic acid having from 2 to 6 carbons such as acetic, propionic, n-butyric acid, isobutyric acid, valeric acid, isovaleric acid, pivalic acid or gluconic acid, and Z is an inorganic anion such as chloride or sulfate. A1, A2, A3 and A4 are preferably α-amino acids having from 2 to 6 carbons such as glycine.

  利用式中的非螯合物配位化合物溶液，可以增强 NMRI 中的 T₁ 和 T₂ 弛豫： [Mn(II)(H₂O)mA1nA2oA3pA4q]+a(Y,Zr)-a 式中 A1、A2、A3 和 A4 是具有 2 至 18 个碳原子的相同或不同的氨基取代的羧酸基团； Y 和 Z 分别是相同或不同的药学上可接受的无机酸阴离子或具有 2 至 18 个碳原子的有机羧酸阴离子； a 是离子的化合价； m、n、o、p 和 q 各为 1 或 0，（m + n + o + p + q）= 4，（n + o + p + q）最好为 1 至 3；以及 r 为 1，如果 Y 是多价阴离子，则 r 为 0 或 1。 溶液的 pH 值范围为 4 至 9.5，优选 5 至 7，最佳为 5 至 6.5，对于肠外给药，配位化合物的浓度为 0.5 至 4.0 wt%。n 最好为 1 至 3，最佳为 2 至 4，最理想为 2 至 3，Y 和 Z 为一价。例如，Y 最好是具有 2 至 6 个碳原子的脂肪族羧酸的阴离子，如乙酸、丙酸、正丁酸、异丁酸、戊酸、异戊酸、特戊酸或葡萄糖酸，Z 是无机阴离子，如氯化物或硫酸盐。A1、A2、A3 和 A4 最好是具有 2 至 6 个碳原子的 α-氨基酸，如甘氨酸。
• Alphavirus vectors for RSV and PIV vaccines
  申请人：Novartis Vaccines and Diagnostics, Inc.

  公开号：EP2811027A1

  公开（公告）日：2014-12-10

  Described herein are compositions and methods for stimulating an immune response to one or more proteins derived from one or more respiratory pathogens. In particular, the invention relates to alphavirus replicons, alphavirus vector constructs, alphavirus replicon particles expressing one or more antigens derived from one or more respiratory pathogens as well as to method of making and using these immunogenic compositions.

  本文描述的是刺激对一种或多种源自一种或多种呼吸道病原体的蛋白质的免疫反应的组合物和方法。特别是，本发明涉及α-病毒复制子、α-病毒载体构建体、表达一种或多种源自一种或多种呼吸道病原体的抗原的α-病毒复制子颗粒，以及制造和使用这些免疫原组合物的方法。
• Alphavirus vectors for influenza virus vaccines
  申请人：Novartis Vaccines and Diagnostics, Inc.

  公开号：EP2848692A1

  公开（公告）日：2015-03-18

  Described herein are compositions and methods for stimulating an immune response to one or more proteins derived from one or more respiratory pathogens. In particular, the invention relates to alphavirus replicons, alphavirus vector constructs, alphavirus replicon particles expressing one or more antigens derived from one or more respiratory pathogens as well as to method of making and using these immunogenic compositions.

  本文描述的是刺激对一种或多种源自一种或多种呼吸道病原体的蛋白质的免疫反应的组合物和方法。特别是，本发明涉及α-病毒复制子、α-病毒载体构建体、表达一种或多种源自一种或多种呼吸道病原体的抗原的α-病毒复制子颗粒，以及制造和使用这些免疫原组合物的方法。
• Chimeric alphavirus replicon particles
  申请人：Chiron Corporation

  公开号：US20030232324A1

  公开（公告）日：2003-12-18

  Chimeric alphaviruses and alphavirus replicon particles are provided including methods of making and using same. Specifically, alphavirus particles are provided having nucleic acid molecules derived from one or more alphaviruses and structural proteins (capsid and/or envelope) from at least two or more alphaviruses. Methods of making, using, and therapeutic preparations containing the chimeric alphavirus particle, are disclosed.

  提供了嵌合字母病毒和字母病毒复制子颗粒，包括其制造和使用方法。具体来说，所提供的α病毒颗粒具有来自一种或多种α病毒的核酸分子和来自至少两种或多种α病毒的结构蛋白（囊膜和/或包膜）。公开了含有嵌合字母病毒颗粒的制造、使用和治疗制剂的方法。