OPB-2045 | 146509-94-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: OPB-2045
• 英文别名: N1-(3',4'-dichlorobenzyl)-N5-octyl-biguanide hydrochloride；1-(3,4-dichlorobenzyl)-5-octylbiguanide monohydrochloride；N1-(3,4-dichlorobenzyl)-N5-octyl biguanide hydrochloride；1-(3,4-dichlorobenzyl)-5-octylbiguanide hydrochloride；olanexidine hydrochloride；1-[N'-[(3,4-dichlorophenyl)methyl]carbamimidoyl]-2-octylguanidine;hydrochloride
• CAS: 146509-94-6
• 化学式: C₁₇H₂₇Cl₂N₅*ClH
• 分子量: 408.802
• InChiKey: GVBQOBUYEOFFLD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.49
• 重原子数：
  25
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  88.8
• 氢给体数：
  4
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  OPB-2045 在 水 作用下， 反应 2.0h， 以81.6%的产率得到1-(3,4-dichlorobenzyl)-5-octylbiguanide monohydrochloride semihydrate
  参考文献：
  名称：

  WO2008/26757

  摘要：

  公开号：
• 作为产物：
  描述：

  二丁基丙基膦酸酯 生成 OPB-2045
  参考文献：
  名称：

  Synthesis and structure-activity relationships of novel antiseptics

  摘要：

  For the purpose of developing new antiseptics, we searched for compounds having high biocidal activity covering both gram-positive and gram-negative bacteria. Accordingly, we designed 1,5-disubstituted biguanides and synthesized them using two alternative efficient reaction schemes. The bactericidal activity of these biguanides was assayed by the micro titration plate method. Among the biguanides synthesized, 3,4-dichlorobenzyl derivatives were found to exhibit particularly high bactericidal activity. Ultimately, compound 11 was chosen as a candidate novel antiseptic, which is currently under continued. evaluation. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00297-7

文献信息

• METHOD AND APPARATUS FOR PREPARING A SOLUTION OF A SHEAR SENSITIVE MATERIAL
  申请人：Hathaway, JR. Royal D.

  公开号：US20090287021A1

  公开（公告）日：2009-11-19

  The invention provides a novel apparatus and method for preparing a solution of a shear sensitive material.

  本发明提供了一种新型的装置和方法，用于制备剪切敏感材料的溶液。
• Novel 2,4-diamino-1,3,5-triazine derivative
  申请人：Maeda Shirou

  公开号：US20060154928A1

  公开（公告）日：2006-07-13

  The present invention relates to an antibacterial agent, which comprises, as an active ingredient, a compound represented by the following general formula (1): or a pharmaceutically acceptable salt thereof.

  本发明涉及一种抗菌剂，其包含以下通式（1）所表示的化合物作为活性成分，或其药学上可接受的盐。
• Aqueous olanexidine solution, method of preparing the same, and disinfectant
  申请人：Miyata Kazuyoshi

  公开号：US20060189500A1

  公开（公告）日：2006-08-24

  The present invention provides a disinfectant that contains olanexidine in a concentration sufficient to exhibit an effective bactericidal effect, and that has hardly any side effects such as skin irritation. Specifically, the present invention provides a disinfectant containing an aqueous solution that contains olanexidine and at least an equimolar amount of gluconic acid, and substantially contains neither an acid other than gluconic acid nor a salt of the acid other than gluconic acid.

  本发明提供了一种消毒剂，其含有足够浓度的奥兰诺蒂汀以表现出有效的杀菌效果，并且几乎没有皮肤刺激等副作用。具体而言，本发明提供了一种消毒剂，其中包含含有奥兰诺蒂汀和至少等摩尔量葡萄糖酸的水溶液，并且几乎不含有葡萄糖酸以外的酸或该酸的盐。
• Biguanide derivatives, manufacturing method thereof, and disinfectants
  申请人：Otsuka Pharmaceutical Co., Ltd.

  公开号：US05376686A1

  公开（公告）日：1994-12-27

  The invention presents a biguanide derivative or its salt expressed by a formula: ##STR1## (where R.sup.1 and R.sup.2 are as defined in Specification), or formula: ##STR2## (where A and R.sup.3 is as defined in specification). This biguanide derivative or its salt is preferably used as the effective amount of a disinfectant for humans, animals, medical appliances, etc.

  该发明提供了一种由以下式子表示的双胍衍生物或其盐：##STR1## （其中R.sup.1和R.sup.2如规范中所定义），或式：##STR2## （其中A和R.sup.3如规范中所定义）。该双胍衍生物或其盐可作为人类、动物、医疗器械等的消毒剂的有效成分。
• Aqueous solution of olanexidine, method of preparing the aqueous solution, and disinfectant
  申请人：Miyata Kazuyoshi

  公开号：US20070041866A1

  公开（公告）日：2007-02-22

  The present invention provides a disinfectant that contains olanexidine in a concentration sufficient to exhibit an effective bactericidal effect, and that has hardly any side effects such as skin irritation. Specifically, the present invention provides a disinfectant containing an aqueous solution that contains olanexidine and at least an equimolar amount of gluconic acid, and substantially contains neither an acid other than gluconic acid nor a salt of the acid other than gluconic acid.

  本发明提供了一种消毒剂，其中含有足够浓度的奥拉内克辛以展现有效的杀菌效果，并且几乎没有皮肤刺激等副作用。具体而言，本发明提供了一种含有水溶液的消毒剂，其中含有奥拉内克辛和至少等摩尔量的葡萄糖酸，并且几乎不含有葡萄糖酸以外的酸或酸的盐。