4-bromo-1-phenylbut-3-yn-1-ol | 41658-14-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-bromo-1-phenylbut-3-yn-1-ol
• 英文别名: 4-bromo-1-phenyl-but-3-yn-1-ol；4-Brom-1-phenyl-but-3-in-1-ol；1-Phenyl-4-brom-3-butin-1-ol
• CAS: 41658-14-4
• 化学式: C₁₀H₉BrO
• 分子量: 225.085
• InChiKey: ALMHHMJLNNLCGG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.47
• 重原子数：
  12.0
• 可旋转键数：
  2.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  20.23
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  4-bromo-1-phenylbut-3-yn-1-ol 在 chromium(VI) oxide 、 硫酸 作用下， 以 丙酮 为溶剂， 生成 1-Phenyl-4-brom-3-butin-1-on
  参考文献：
  名称：

  Vereshchagin,L.I. et al., Journal of Organic Chemistry USSR (English Translation), 1973, vol. 9, p. 514 - 518

  摘要：

  DOI：
• 作为产物：
  描述：

  1-苯基-3-丁炔-1-醇 在 次溴酸钾 作用下， 生成 4-bromo-1-phenylbut-3-yn-1-ol
  参考文献：
  名称：

  The Prevalence of Daytime Napping and Its Relationship to Nighttime Sleep

  摘要：

  Many healthy adults report daytime napping. Surprisingly few studies, however have examined spontaneous napping behavior especially very short naps, in healthy adults. The authors examined the prevalence of power naps (lasting less than 20 minutes) and longer naps (20 minutes or more) and their effects on nighttime sleep in a group of healthy young and middle-aged adults. The young and middle-aged adults reported very similar sleep and napping patterns, with approximately 74% of the participants in both groups reporting they had napped during a 7-day sleep-log period. Almost half of the participants reported that the average nap lasted less than 20 minutes. A multivariant analysis of variance (MANOVA) found no significant differences between the no-nap and the power-nap or long-nap groups in sleep quantity or quality for either age group. The current data suggested that power napping occurs frequently in healthy adults and that spontaneous napping does not negatively affect nighttime sleep.

  DOI：

  10.1080/08964280109595773

文献信息

• Trapping Reactions of Benzynes Initiated by Intramolecular Nucleophilic Addition of a Carbonyl Oxygen to the Electrophilic Aryne
  作者：Bhavani Shankar Chinta、Sahil Arora、Thomas R. Hoye

  DOI：10.1021/acs.orglett.1c04110

  日期：2022.1.14

  We describe here reactions in which a carbonyl oxygen atom initiates cascade reactions by nucleophilic attack on a covalently attached benzyne. The benzynes are produced by thermal cyclization of triynes via hexadehydro-Diels–Alder reaction. The initially produced oxocarbenium/aryl carbanionic zwitterion is protonated in situ by an external protic nucleophile (NuH) of appropriate acidity. The resulting

  我们在这里描述了羰基氧原子通过对共价连接的苯进行亲核攻击而引发级联反应的反应。苯炔是通过六氢-Diels-Alder 反应通过三炔的热环化产生的。最初产生的氧碳正离子/芳基碳负离子两性离子被适当酸度的外部质子亲核试剂 (NuH) 原位质子化。由此产生的离子对 (oxocarbenium + /Nu – ) 通过几个不同的机械流形崩溃，增加了可以生成的结构类别的多样性。