(4S,5S)-4-(cyclohexylmethyl)-5-vinyloxazolidin-2-one | 104856-08-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: (4S,5S)-4-(cyclohexylmethyl)-5-vinyloxazolidin-2-one
• 英文别名: (4S,5S)-4-(cyclohexylmethyl)-5-ethenyl-1,3-oxazolidin-2-one
• CAS: 104856-08-8
• 化学式: C₁₂H₁₉NO₂
• 分子量: 209.288
• InChiKey: CTHMOVCPUUIPBN-QWRGUYRKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (4S,5S)-4-(cyclohexylmethyl)-5-vinyloxazolidin-2-one 在 barium dihydroxide 、 N,N-二异丙基乙胺 、 间氯过氧苯甲酸 作用下， 以 1,4-二氧六环 、 二氯甲烷 、 水 为溶剂， 反应 71.25h， 生成 (2RS,3R,4S)-4-<(tert-butyloxycarbonyl)amino>-5-cyclohexyl-3-<(2-methoxyethoxy)methoxy>-1,2-epoxypentane
  参考文献：
  名称：

  Azido glycols: potent, low molecular weight renin inhibitors containing an unusual post scissile site residue

  摘要：

  Azidomethyl-substituted 1,2- and 1,3-diols were prepared from Boc-cyclohexylalanal and evaluated as transition state analogue renin inhibitors, leading to the development of a small (MW less than 600), nanomolar inhibitor. Remarkable aqueous solubility enhancement followed the incorporation of an N-terminal urea functionality. Evaluation of selected compounds both in vivo and in vitro demonstrated that while transport across the intestine occurred upon id administration, extensive liver extraction resulted in low systemic levels.

  DOI：

  10.1021/jm00126a038
• 作为产物：
  描述：

  (alphaS)-alpha-[[(1,1-二甲基乙氧基)羰基]氨基]-环己烷丙酸甲酯 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 以80%的产率得到(4S,5S)-4-(cyclohexylmethyl)-5-vinyloxazolidin-2-one
  参考文献：
  名称：

  Renin inhibitors. Dipeptide analogs of angiotensinogen incorporating transition-state, nonpeptidic replacements at the scissile bond

  摘要：

  A series of dipeptide analogues of angiotensinogen have been prepared and evaluated for their ability to inhibit the aspartic proteinase renin. The compounds were derived from the renin substrate by replacing the scissile amide bond with a transition-state mimic and by incorporating bioisosteric replacements for the Val-10 amide bond. Analogue 21a exhibited an IC50 of 7.6 nM against purified human renin, showed high specificity for this enzyme, and produced a hypotensive response in anesthetized, salt-depleted cynomolgus monkeys.

  DOI：

  10.1021/jm00393a008

文献信息

• ROSENBERG, SAUL H.;LULY, JAY R.;PLATTNER, JACOB J.
  作者：ROSENBERG, SAUL H.、LULY, JAY R.、PLATTNER, JACOB J.

  DOI：——

  日期：——
• ROSENBERG, SAUL H.;WOODS, KEITH W.;KLEINERT, HOLLIS D.;STEIN, HERMAN;NELL+, J. MED. CHEM., 32,(1989) N, C. 1371-1378
  作者：ROSENBERG, SAUL H.、WOODS, KEITH W.、KLEINERT, HOLLIS D.、STEIN, HERMAN、NELL+

  DOI：——

  日期：——
• BOLIS, GIORGIO;FUNG, ANTHONY K. L.;GREER, JONATHAN;KLEINERT, HOLLIS D.;MA+, J. MED. CHEM., 30,(1987) N 10, 1729-1737
  作者：BOLIS, GIORGIO、FUNG, ANTHONY K. L.、GREER, JONATHAN、KLEINERT, HOLLIS D.、MA+

  DOI：——

  日期：——
• US5134123A
  申请人：——

  公开号：US5134123A

  公开（公告）日：1992-07-28
• US5256645A
  申请人：——

  公开号：US5256645A

  公开（公告）日：1993-10-26