1,4,5-tri-O-acetyl-2,3,6-tri-O-methyl-D-glucitol | 20250-41-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1,4,5-tri-O-acetyl-2,3,6-tri-O-methyl-D-glucitol
• 英文别名: 1,4,5-tri-O-acetyl-2,3,6-tri-O-methylglucitol；1,4,5-tri-O-acetyl-2,3,6-tri-O-methylsorbitol；[(2S,3R,4R,5R)-4,5-diacetyloxy-2,3,6-trimethoxyhexyl] acetate
• CAS: 20250-41-3
• 化学式: C₁₅H₂₆O₉
• 分子量: 350.366
• InChiKey: ATVQUEJOBOKGCC-GBJTYRQASA-N

物化性质

• 沸点：
  398.5±42.0 °C(Predicted)
• 密度：
  1.140±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  24
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  107
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  (2R,3R,5R,6R)-2-(hydroxymethyl)-6-(4-nitrophenoxy)oxane-3,4,5-triol 生成 1,4,5-tri-O-acetyl-2,3,6-tri-O-methyl-D-glucitol
  参考文献：
  名称：

  SHEA, ELAINE M.;CARPITA, NICHOLAS C., J. CHROMATOGR., 445,(1988) N 2, 424-428

  摘要：

  DOI：

文献信息

• Enzymic syntheses of doubly branched cyclomaltoheptaoses through the reverse action of Pseudomonas isoamylase
  作者：Jun-ichi Abe、Susumu Hizukuri、Kyoko Koizumi、Yoko Kubota、Toshiko Utamura

  DOI：10.1016/0008-6215(88)84060-6

  日期：1988.5

  Abstract Two and three new cyclomaltoheptaose (β-cyclodextrin, cG 7 ) derivatives, respectively, were identified among the products obtained by the action of Pseudomonas isoamylase on maltose and maltotriose, and cG 7 . They were 6 A ,6 D -di- O -α-maltosyl-cG 7 and 6- O -α-(6 2 - O -α-maltosyl)maltosyl-cG 7 , and 6 A ,6 D -di- O -α-maltotriosyl-cG 7 , 6- O -α-(6 3 - O -α-maltotriosyl)maltotriosyl-cG

  摘要在假单胞菌异淀粉酶对麦芽糖和麦芽三糖以及cG 7的作用下，分别鉴定出2个和3个新的环麦芽七糖（β-环糊精，cG 7）衍生物。它们是6 A，6 D -di-O-α-麦芽糖基-cG 7和6- O-α-（6 2-O-α-麦芽糖基）麦芽糖基-cG 7，以及6 A，6 D -di-O -α-麦芽三糖基-cG 7，6-O-α-（6 3 -O-α-麦芽三糖基）麦芽三糖基-cG 7和6-O-α-（6 2-O-α-麦芽三糖基）麦芽三糖基-cG 7 。另外，鉴定出6 1-和6 2-O-α-麦芽糖基麦芽糖是麦芽糖的相互缩合产物。麦芽糖是充当假单胞菌异淀粉酶作用的受体和供体的最小底物。
• Synthesis of branched cyclomalto-oligosaccharides using Pseudomonas isoamylase
  作者：Jun-ichi Abe、Naoki Mizowaki、Susumu Hizukuri、Kyoko Koizumi、Toshiko Utamura

  DOI：10.1016/s0008-6215(00)90024-7

  日期：1986.10

  Branched cyclomalto-oligosaccharides (cyclodextrins) were synthesised from cyclomalto-oligosaccharides and maltose or maltotriose through the reverse action of Pseudomonas isoamylase. The reaction rate was greater with maltotriose than with maltose, and with increasing size of the cyclomalto-oligosaccharide (cG6 less than cG7 less than cG8). Maltotriose is effective as both a side-chain donor and acceptor

  通过假单胞菌异淀粉酶的逆作用，由环麦芽低聚糖和麦芽糖或麦芽三糖合成支化的环麦芽低聚糖（cyclodextrins）。麦芽三糖的反应速率大于麦芽糖，并且环麦芽寡糖的尺寸增加（cG6小于cG7小于cG8）。麦芽三糖作为侧链供体和受体都是有效的，并且通过相互缩合形成6-O-α-麦芽三糖基麦芽三糖的三个异构体（支链G6），但是麦芽糖仅作为侧链供体有效。通过液相色谱法纯化每个分支的环麦芽低聚糖和G6，并通过化学，酶和13C-nmr光谱分析确定它们的结构。
• Branched alpha-glucan, alpha-glucosyltransferase which forms the glucan, their preparation and uses
  申请人：Watanabe Hikaru

  公开号：US20100120710A1

  公开（公告）日：2010-05-13

  The present invention has objects to provide a glucan useful as water-soluble dietary fiber, its preparation and uses. The present invention solves the above objects by providing a branched α-glucan, which is constructed by glucose molecules and characterized by methylation analysis as follows: (1) Ratio of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol to 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is in the range of 1:0.6 to 1:4; (2) Total content of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol and 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is 60% or higher in the partially methylated glucitol acetates; (3) Content of 2,4,6-trimethyl-1,3,5-triacetyl-glucitol is 0.5% or higher but less than 10% in the partially methylated glucitol acetates; and (4) Content of 2,4-dimethyl-1,3,5,6-tetraacetyl-glucitol is 0.5% or higher in the partially methylated glucitol acetates; a novel α-glucosyltransferase which forms the branched α-glucan, processes for producing them, and their uses.

  本发明的目的是提供一种作为水溶性膳食纤维有用的葡聚糖、其制备和用途。本发明通过提供一种分支α-葡聚糖来解决上述目的，该葡聚糖由葡萄糖分子构成，其特征通过甲基化分析如下：（1）2,3,6-三甲基-1,4,5-三乙酰-葡萄糖醇与2,3,4-三甲基-1,5,6-三乙酰-葡萄糖醇的比率在1:0.6至1:4的范围内；（2）2,3,6-三甲基-1,4,5-三乙酰-葡萄糖醇和2,3,4-三甲基-1,5,6-三乙酰-葡萄糖醇的总含量在部分甲基化葡萄糖醇醋酸酯中达到60％或更高；（3）2,4,6-三甲基-1,3,5-三乙酰-葡萄糖醇的含量在部分甲基化葡萄糖醇醋酸酯中为0.5％或更高，但小于10％；（4）2,4-二甲基-1,3,5,6-四乙酰-葡萄糖醇的含量在部分甲基化葡萄糖醇醋酸酯中为0.5％或更高。本发明还提供了一种形成分支α-葡聚糖的新型α-葡萄糖基转移酶，用于生产它们的方法以及它们的用途。
• BRANCHED ALPHA-GLUCAN, ALPHA-GLUCOSYLTRANSFERASE WHICH FORMS THE GLUCAN, THEIR PREPARATION AND USES
  申请人：Hayashibara Co., Ltd.

  公开号：US20130065293A1

  公开（公告）日：2013-03-14

  The present invention has objects to provide a glucan useful as water-soluble dietary fiber, its preparation and uses. The present invention solves the above objects by providing a branched α-glucan, which is constructed by glucose molecules and characterized by methylation analysis as follows: (1) Ratio of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol to 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is in the range of 1:0.6 to 1:4; (2) Total content of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol and 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is 60% or higher in the partially methylated glucitol acetates; (3) Content of 2,4,6-trimethyl-1,3,5-triacetyl-glucitol is 0.5% or higher but less than 10% in the partially methylated glucitol acetates; and (4) Content of 2,4-dimethyl-1,3,5,6-tetraacetyl-glucitol is 0.5% or higher in the partially methylated glucitol acetates; a novel α-glucosyltransferase which forms the branched α-glucan, processes for producing them, and their uses.

  本发明旨在提供一种作为水溶性膳食纤维有用的葡聚糖，其制备和用途。本发明通过提供一种支链α-葡聚糖来解决上述问题，该支链α-葡聚糖由葡萄糖分子构成，并通过甲基化分析表征，其特征如下：(1) 2,3,6-三甲基-1,4,5-三乙酰基-葡萄糖醇与2,3,4-三甲基-1,5,6-三乙酰基-葡萄糖醇的比率在1:0.6至1:4范围内；(2) 在部分甲基化的葡萄糖醇醋酸酯中，2,3,6-三甲基-1,4,5-三乙酰基-葡萄糖醇和2,3,4-三甲基-1,5,6-三乙酰基-葡萄糖醇的总含量为60％或更高；(3) 在部分甲基化的葡萄糖醇醋酸酯中，2,4,6-三甲基-1,3,5-三乙酰基-葡萄糖醇的含量为0.5％或更高，但小于10％；(4) 在部分甲基化的葡萄糖醇醋酸酯中，2,4-二甲基-1,3,5,6-四乙酰基-葡萄糖醇的含量为0.5％或更高。本发明还提供了一种新型α-葡萄糖基转移酶，用于形成支链α-葡聚糖，以及生产它们的方法和用途。
• Lactoneotrehalose, and its preparation and uses
  申请人：KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO

  公开号：EP0480640A1

  公开（公告）日：1992-04-15

  Lactoneotrehalose, a novel saccharide shown by the formula O-β-D-galactopyranosyl-(1→4)-O-β-D-glucopyranosyl α-D-glucopyranoside, is prepared by allowing a saccharide-transferring enzyme to act on an aqueous solution containing lactose and amylaceous substance. Lactoneotrehalose is a non-reducing oligosaccharide, extremely stable, readily soluble in water, and substantially free of hygroscopicity, as well as having a satisfiable quality and moderate sweetness. These render lactoneotrehalose very useful in the preparations of orally-administrable products, cosmetics and pharmaceuticals.

  Lactoneotrehalose 是一种新型糖，其分子式为 O-β-D-吡喃半乳糖基-(1→4)-O-β-D-吡喃葡萄糖基 α-D-吡喃葡萄糖苷，其制备方法是让糖转移酶作用于含有乳糖和淀粉物质的水溶液。乳酮海藻糖是一种非还原性低聚糖，非常稳定，易溶于水，基本上没有吸湿性，而且具有令人满意的品质和适度的甜味。因此，乳酮海藻糖在口服产品、化妆品和药品的制备中非常有用。