3-amino-4-(cyclohexylamino)pyridine | 75125-70-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-amino-4-(cyclohexylamino)pyridine
• 英文别名: 3-amino-4-cyclohexylaminopyridine；N⁴-cyclohexyl-pyridine-3,4-diyldiamine；N⁴-Cyclohexyl-pyridin-3,4-diyldiamin；4-N-cyclohexylpyridine-3,4-diamine
• CAS: 75125-70-1
• 化学式: C₁₁H₁₇N₃
• 分子量: 191.276
• InChiKey: XNQPSIWZSBKMKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  50.9
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-amino-4-(cyclohexylamino)pyridine 在 硫酸 、 硝酸 作用下， 以70%的产率得到1-cyclohexyl-4-nitro-1H-[1,2,3]triazolo[4,5-c]pyridine 2-oxide
  参考文献：
  名称：

  Cyclization of substituted 3,4-diaminopyridines into 1H-[1,2,3]triazolo[4,5-c]pyridine 2-oxide derivatives during the nitration process

  摘要：

  The nitration of pyridine-3,4-diamine, its N,N'-diacetyl derivative, and N(4)-alkylpyridine-3,4-diamines with excess nitric acid in concentrated sulfuric acid at 60 degrees C was accompanied by cyclization with formation of the corresponding 1-substituted 4-nitro-1H-[1,2,3]triazolo[4,5-c]pyridine 2-oxides. 4-Chloro-1H-[1,2,3] triazolo[4,5-c] pyridine 2-oxide derivatives were obtained under analogous conditions from 2-chloropyridine-3,4-diamine, its N, N'-diacetyl derivative, and 2-chloro-N(4)-methylpyridine-3,4-diamine. The nitration of these compounds at 80-90 degrees C gave 4-chloro-7-nitro-1H-[1,2,3] triazolo[4,5-c] pyridine 2-oxides.

  DOI：

  10.1134/s1070428010080178
• 作为产物：
  描述：

  N-(3-nitropyridin-4-yl)cyclohexylamine 在 palladium on activated charcoal 氢气 作用下， 生成 3-amino-4-(cyclohexylamino)pyridine
  参考文献：
  名称：

  (1H-Imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: A novel class of potent MSK-1-inhibitors

  摘要：

  A novel series of imidazo[4,5-c]pyridines bearing a 1,2,5-oxadiazol-3-ylamine functionality has been developed. These are potent inhibitors of mitogen and stress-activated protein kinase-1. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.05.021

文献信息

• MICROBICIDALLY ACTIVE IMIDAZOPYRIDINE DERIVATIVES
  申请人：SYNGENTA PERTICIPATIONS AG

  公开号：US20160016949A1

  公开（公告）日：2016-01-21

  The present invention provides compounds of formula (I) wherein Y 1 , Y 2 , Y 3 , G, V 1 , V 2 , V 3 and V 4 are as defined in the claims. The invention further relates to compositions which comprise these compounds and to their use in agriculture or horticulture for controlling or preventing infestation of plants by phytopathogenic microorganisms, preferably fungi.

  本发明提供了式（I）的化合物，其中Y1、Y2、Y3、G、V1、V2、V3和V4如权利要求所定义。本发明还涉及包含这些化合物的组合物，并且涉及它们在农业或园艺中的使用，用于控制或预防植物被植物病原微生物，优选为真菌，侵染。
• Thionation of imidazopyridines
  作者：Yu. M. Yutilov、I. A. Svertilova

  DOI：10.1007/bf00475602

  日期：1988.6
• 916. The Graebe–Ullmann carbazole synthesis
  作者：B. W. Ashton、H. Suschitzky

  DOI：10.1039/jr9570004559

  日期：——
• Rasala, D., Bulletin de la Societe Chimique de France, 1992, # 1, p. 79 - 84
  作者：Rasala, D.

  DOI：——

  日期：——
• Ashton; Suschitzky, Journal of the Chemical Society, <1957> 4559, 4561
  作者：Ashton、Suschitzky

  DOI：——

  日期：——