4-[2-(5-Methyl-2,4-dioxopyrimidin-1-yl)acetyl]-1,4,7,10-tetrazacyclododecane-2,8-dione | 289684-55-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酰胺类
• 英文名称: 4-[2-(5-Methyl-2,4-dioxopyrimidin-1-yl)acetyl]-1,4,7,10-tetrazacyclododecane-2,8-dione
• 英文别名: 4-[2-(5-methyl-2,4-dioxopyrimidin-1-yl)acetyl]-1,4,7,10-tetrazacyclododecane-2,8-dione
• CAS: 289684-55-5
• 化学式: C₁₅H₂₂N₆O₅
• 分子量: 366.377
• InChiKey: VZWAWISRXAQGKQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.9
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  140
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-[2-(5-Methyl-2,4-dioxopyrimidin-1-yl)acetyl]-1,4,7,10-tetrazacyclododecane-2,8-dione 在 氨 、 (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 、 N,N-二异丙基乙胺 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 生成 4-[2-(6-Amino-purin-9-yl)-acetyl]-10-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-1,4,7,10-tetraaza-cyclododecane-2,8-dione
  参考文献：
  名称：

  An expeditious liquid-phase synthesis of cyclic peptide nucleic acids

  摘要：

  Suitably protected linear precursors of cyclic PNAs can be readily obtained by BOP/DiPEA coupling of the corresponding sub-monomers. Conversion of the linear PNA dimers into the pentafluorophenyl esters allows cyclization by intramolecular attack of the deprotected primary amino function under diluted conditions. After removal of the secondary amino protecting group(s), installation of the required nucleobase-acetyl function(s) affords cyclic PNAs. In addition, the latter compounds can be prepared following a direct coupling strategy. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00536-0
• 作为产物：
  描述：

  Methyl 2-[2-aminoethyl-[2-(5-methyl-2,4-dioxopyrimidin-1-yl)acetyl]amino]acetate 在 palladium on activated charcoal sodium hydroxide 、 水 、 氢气 、 (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 、 N,N-二异丙基乙胺 作用下， 以 甲醇 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 、 异丙醇 、 乙腈 为溶剂， 生成 4-[2-(5-Methyl-2,4-dioxopyrimidin-1-yl)acetyl]-1,4,7,10-tetrazacyclododecane-2,8-dione
  参考文献：
  名称：

  An expeditious liquid-phase synthesis of cyclic peptide nucleic acids

  摘要：

  Suitably protected linear precursors of cyclic PNAs can be readily obtained by BOP/DiPEA coupling of the corresponding sub-monomers. Conversion of the linear PNA dimers into the pentafluorophenyl esters allows cyclization by intramolecular attack of the deprotected primary amino function under diluted conditions. After removal of the secondary amino protecting group(s), installation of the required nucleobase-acetyl function(s) affords cyclic PNAs. In addition, the latter compounds can be prepared following a direct coupling strategy. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00536-0

文献信息

• An expeditious liquid-phase synthesis of cyclic peptide nucleic acids
  作者：Jeroen C Verheijen、Gijsbert M Grotenbreg、Ludo Hart de Ruyter、Pieter A.M van der Klein、Gijsbert A van der Marel、Jacques H van Boom

  DOI：10.1016/s0040-4039(00)00536-0

  日期：2000.5

  Suitably protected linear precursors of cyclic PNAs can be readily obtained by BOP/DiPEA coupling of the corresponding sub-monomers. Conversion of the linear PNA dimers into the pentafluorophenyl esters allows cyclization by intramolecular attack of the deprotected primary amino function under diluted conditions. After removal of the secondary amino protecting group(s), installation of the required nucleobase-acetyl function(s) affords cyclic PNAs. In addition, the latter compounds can be prepared following a direct coupling strategy. (C) 2000 Elsevier Science Ltd. All rights reserved.