3,4,5,6-tetrachloro-2-methylpyridine | 10469-02-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3,4,5,6-tetrachloro-2-methylpyridine
• 英文别名: 2,3,4,5-tetrachloro-6-methyl-pyridine；pyridine-carbon tetrachloride；3,4,5,6-Tetrachlor-2-methyl-pyridin；3,4,5,6-Tetrachlor-2-methylpyridin；2-Methyltetrachloropyridin；2-Methyltetrachlorpyridin；2,3,4,5-Tetrachloro-6-methylpyridine
• CAS: 10469-02-0
• 化学式: C₆H₃Cl₄N
• 分子量: 230.909
• InChiKey: OZLPEWBQZDDFCQ-UHFFFAOYSA-N

物化性质

• 熔点：
  92-93 °C(Solv: water (7732-18-5); ethanol (64-17-5))
• 沸点：
  264.2±35.0 °C(Predicted)
• 密度：
  1.573±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3,4,5,6-tetrachloro-2-methylpyridine 在 三氯化铝 、 氯 作用下， 以 四氯化碳 为溶剂， 反应 27.0h， 生成 diphenyl(tetrachloro-2-pyridyl)methane
  参考文献：
  名称：

  Inert carbon free radicals. 9. The first perchlorinated triarylmethyl and fluorenyl radicals with a heteroaromatic ring, and related compounds

  摘要：

  DOI：

  10.1021/jo00241a026
• 作为产物：
  描述：

  3,4,5,6-Tetrachlorpyridyl-2-essigsaeure 以95%的产率得到
  参考文献：
  名称：

  MOSHCHITSKIJ S. D.; PAVLENKO A. F.; ZALESSKIJ G. A., XIMIYA GETEROTSIKL. SOEDIN., 1978, HO 7, 950-953

  摘要：

  DOI：

文献信息

• Immuno-suppressive agent
  申请人：Ishihara Sangyo Kaisha Ltd.

  公开号：US05380834A1

  公开（公告）日：1995-01-10

  An immuno-suppressive agent containing, as an effective component, an, enopyranose derivative of the following formula (I) or its salt: ##STR1## wherein R.sup.1 is a hydrogen atom, alkyl which may be substituted, alkenyl, alkynyl, --OSO.sub.2 R.sup.7, a halogen atom, --OCOR.sup.7, --NHCOR.sup.8, alkoxy, phenyl which may be substituted or a saccharose residue, R.sup.2 is a hydrogen atom or alkyl, R.sup.3 is a hydrogen atom or a halogen atom, R.sup.4 is a hydrogen atom, --COR.sup.9, silyl which may be substituted or alkyl which may be substituted, one of R.sup.5 and R.sup.6 is hydroxyl, alkoxy which may be substituted, a saccharose residue, cycloalkyloxy which may be substituted or --OCOR.sup.10 and the other is a hydrogen atom or alkyl which may be substituted, or R.sup.4 and R.sup.5 together form a single bond, while R.sup.6 is a hydrogen atom or alkyl which may be substituted, each of R.sup.7, R.sup.9 and R.sup.10 is alkyl or phenyl which may be substituted, R.sup.8 is alkyl, phenyl which may be substituted or benzyloxy, X is a hydrogen atom, alkyl which may be substituted, alkenyl which may be substituted, alkynyl which may be substituted, cycloalkyl which may be substituted, phenyl which may be substituted, pyridyl which may be substituted, furanyl which may be substituted, thienyl which may be substituted, formyl, --COR.sup.11, --C(W.sup.1)W.sup.2 R.sup.11 or --SO.sub.2 R.sup.11, R.sup.11 is a chain hydrocarbon group which may be substituted, a monocyclic hydrocarbon group which may be substituted, a polycyclic hydrocarbon group which may be substituted, a monocyclic heterocycle group which may be substituted, or a polycyclic heterocycle group which may be substituted, W.sup.1 is an oxygen atom or a sulfur atom, W.sup.2 is an oxygen atom, a sulfur atom or --NH--, Y is a hydrogen atom, alkyl which may be substituted, alkenyl which may be substituted or alkynyl which may be substituted.

  一种免疫抑制剂，其有效成分为以下式（I）或其盐的烯基吡喃糖衍生物： 其中R.sup.1是氢原子，可以被取代的烷基，烯基，炔基，--OSO.sub.2 R.sup.7，卤原子，--OCOR.sup.7，--NHCOR.sup.8，烷氧基，可以被取代的苯基或蔗糖残基，R.sup.2是氢原子或烷基，R.sup.3是氢原子或卤原子，R.sup.4是氢原子，--COR.sup.9，可以被取代的硅基或可以被取代的烷基，R.sup.5和R.sup.6中的一个是羟基，可以被取代的烷氧基，蔗糖残基，可以被取代的环烷氧基或--OCOR.sup.10，另一个是氢原子或可以被取代的烷基，或者R.sup.4和R.sup.5一起形成单键，而R.sup.6是氢原子或可以被取代的烷基，R.sup.7，R.sup.9和R.sup.10中的每一个是可以被取代的烷基或苯基，R.sup.8是烷基，可以被取代的苯基或苄氧基，X是氢原子，可以被取代的烷基，可以被取代的烯基，可以被取代的炔基，可以被取代的环烷基，可以被取代的苯基，可以被取代的吡啶基，可以被取代的呋喃基，可以被取代的噻吩基，甲酰基，--COR.sup.11，--C(W.sup.1)W.sup.2 R.sup.11或--SO.sub.2 R.sup.11，R.sup.11是可以被取代的链烃基，可以被取代的单环烃基，可以被取代的多环烃基，可以被取代的单环杂环基，或者可以被取代的多环杂环基，W.sup.1是氧原子或硫原子，W.sup.2是氧原子，硫原子或--NH--，Y是氢原子，可以被取代的烷基，可以被取代的烯基或可以被取代的炔基。
• CONJUGATES OF TUMOR NECROSIS FACTOR INHIBITORS TO FUNCTIONALIZED POLYMERS
  申请人：QuiaPEG AB

  公开号：US20140030278A1

  公开（公告）日：2014-01-30

  This document relates to conjugates of TNF inhibitors or derivatives thereof and functionalized (e.g., mono- or bi-functional) polymers (e.g., polyethylene glycol and related polymers) as well as methods and materials for making and using such conjugates.

  该文件涉及TNF抑制剂或其衍生物与功能化（例如单向或双向）聚合物（例如聚乙二醇和相关聚合物）的共轭物，以及制备和使用这种共轭物的方法和材料。
• CONJUGATES OF BIOLOGICALLY ACTIVE MOLECULES TO FUNCTIONALIZED POLYMERS
  申请人：QuiaPEG AB

  公开号：US20150147345A1

  公开（公告）日：2015-05-28

  This document relates to conjugates of a biologically active molecule or a derivative thereof and functionalized (e.g., mono- or bi-functional) polymers (e.g., polyethylene glycol and related polymers) as well as methods and materials for making and using such conjugates.

  本文件涉及到生物活性分子或其衍生物的共轭物以及功能化（例如单向或双向）聚合物（例如聚乙二醇和相关聚合物），以及制备和使用此类共轭物的方法和材料。
• Immuno-suppressing enepyranose derivatives
  申请人：ISHIHARA SANGYO KAISHA, LTD.

  公开号：EP0560055A1

  公开（公告）日：1993-09-15

  An immuno-suppressive agent containing, as an effective component, an enopyranose derivative of the following formula (I) or its salt: wherein R1 is a hydrogen atom, alkyl which may be substituted, alkenyl, alkynyl, -OSO2R7, a halogen atom, -OCOR7, -NHCOR8, alkoxy, phenyl which may be substituted or a saccharose residue, R2 is a hydrogen atom or alkyl, R3 is a hydrogen atom or a halogen atom, R4 is a hydrogen atom, -COR9, silyl which may be substituted or alkyl which may be substituted, one of R5 and R6 is hydroxyl, alkoxy which may be substituted, a saccharose residue, cycloalkyloxy which may be substituted or -OCOR10 and the other is a hydrogen atom or alkyl which may be substituted, or R4 and R5 together form a single bond, while R6 is a hydrogen atom or alkyl which may be substituted, each of R7, R9 and R10 is alkyl or phenyl which may be substituted, R8 is alkyl, phenyl which may be substituted or benzyloxy, X is a hydrogen atom, alkyl which may be substituted, alkenyl which may be substituted, alkynyl which may be substituted, cycloalkyl which may be substituted, phenyl which may be substituted, pyridyl which may be substituted, furanyl which may be substituted, thienyl which may be substituted, formyl, -COR11, -C(W1)W2R11 or -SO2R11, R11 is a chain hydrocarbon group which may be substituted, a monocyclic hydrocarbon group which may be substituted, a polycyclic hydrocarbon group which may be substituted, a monocyclic heterocycle group which may be substituted, or a polycyclic heterocycle group which may be substituted, W1 is an oxygen atom or a sulfur atom, W2 is an oxygen atom, a sulfur atom or -NH-, Y is a hydrogen atom, alkyl which may be substituted, alkenyl which may be substituted or alkynyl which may be substituted.

  一种含有下式(I)的烯吡喃糖衍生物或其盐作为有效成分的免疫抑制剂： 其中 R1 是氢原子、可被取代的烷基、烯基、炔基、-OSO2R7、卤素原子、-OCOR7、-NHCOR8、烷氧基、可被取代的苯基或糖残基；R2 是氢原子或烷基；R3 是氢原子或卤素原子；R4 是氢原子、-COR9、可被取代的硅烷基或可被取代的烷基；R5 和 R6 中的一个是羟基、可被取代的烷氧基、糖残基、可被取代的环烷氧基或-OCOR10，另一个是氢原子或可被取代的烷基，或 R4 和 R5 一起形成单键，而 R6 是氢原子或可被取代的烷基，R7、R9 和 R10 各为烷基或可被取代的苯基，R8 是烷基、可被取代的苯基或苄氧基，X 是氢原子、可被取代的烷基，可被取代的烯基，可被取代的炔基，可被取代的环烷基，可被取代的苯基，可被取代的吡啶基，可被取代的呋喃基，可被取代的噻吩基，甲酰基，-COR11，-C(W1)W2R11 或-SO2R11，R11 是可被取代的链烃基，可被取代的单环烃基、W1 是氧原子或硫原子，W2 是氧原子、硫原子或-NH-，Y 是氢原子、可被取代的烷基、可被取代的烯基或可被取代的炔基。
• Conjugates of biologically active molecules to functionalized polymers
  申请人：QuiaPEG Pharmaceuticals AB

  公开号：US10010621B2

  公开（公告）日：2018-07-03

  This document relates to conjugates of a biologically active molecule or a derivative thereof and functionalized (e.g., mono- or bi-functional) polymers (e.g., polyethylene glycol and related polymers) as well as methods and materials for making and using such conjugates.

  本文涉及生物活性分子或其衍生物与官能化（如单官能或双官能）聚合物（如聚乙二醇及相关聚合物）的共轭物，以及制造和使用这种共轭物的方法和材料。