6-phenyldihydropyrimidine-2,4(1H,3H)-dione | 6300-95-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-phenyldihydropyrimidine-2,4(1H,3H)-dione
• 英文别名: 5,6-dihydro-6-phenylpyrimidine-2,4(1H,3H)-dione；6-phenylhexahydropyrimidine-2,4-dione；6-phenyl-5,6-dihydrouracil；6-phenyl-dihydro-pyrimidine-2,4-dione；6-Phenyl-dihydro-pyrimidin-2,4-dion；6-phenyl-5,6-dihydropyrimidine-2,4-dione；6-phenyl-1,3-diazinane-2,4-dione
• CAS: 6300-95-4
• 化学式: C₁₀H₁₀N₂O₂
• mdl: MFCD00568365
• 分子量: 190.202
• InChiKey: GTYVCYXIFVPPIP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-phenyldihydropyrimidine-2,4(1H,3H)-dione 在 chlorosulphuric acid 作用下， 生成 4-(2,6-dioxo-hexahydro-pyrimidin-4-yl)-benzenesulfonyl chloride
  参考文献：
  名称：

  Kurtev; Golovinsky, Doklady Bolgarskoi Akademii Nauk, 1958, vol. 11, p. 383,384

  摘要：

  DOI：
• 作为产物：
  描述：

  DL-3-氨基-3-苯基丙酸 生成 6-phenyldihydropyrimidine-2,4(1H,3H)-dione
  参考文献：
  名称：

  Posner, Chemische Berichte, 1905, vol. 38, p. 2316

  摘要：

  DOI：

文献信息

• [EN] SMALL MOLECULES AGAINST CEREBLON TO ENHANCE EFFECTOR T CELL FUNCTION<br/>[FR] PETITES MOLÉCULES DIRIGÉES CONTRE LE CÉRÉBLON POUR AMÉLIORER LA FONCTION DES LYMPHOCYTES T EFFECTEURS
  申请人：H LEE MOFFITT CANCER CENTER & RES INST INC

  公开号：WO2017161119A1

  公开（公告）日：2017-09-21

  Disclosed are small molecules against cereblon to enhance effector T cell function. Methodos of making thes molecules and methods of using them to treat various disease states are also disclosed.

  披露了针对小脑蛋白以增强效应T细胞功能的小分子。还披露了制造这些分子的方法以及使用它们治疗各种疾病状态的方法。
• [EN] THERAPEUTIC COMPOUNDS FOR TREATING DYSLIPIDEMIC CONDITIONS<br/>[FR] COMPOSES THERAPEUTIQUES DESTINES AU TRAITEMENT D'ETATS DYSLIPIDEMIQUES
  申请人：MERCK & CO INC

  公开号：WO2004011448A1

  公开（公告）日：2004-02-05

  The present invention relates to novel LXR ligands of Formula I and the pharmaceutically acceptable salts, esters and tautomers thereof, which are useful in the treatment of dyslipidemic conditions, particularly depressed levels of HDL cholesterol.

  本发明涉及式I的新LXR配体及其药用可接受的盐、酯和互变异构体，它们在治疗血脂异常状况，特别是低HDL胆固醇水平方面具有用途。
• A New Route to 5,6-Dihydropyrimidin-4(3<i>H</i>)-ones
  作者：Lucjan Strekowski、Rebecca A. Watson、Michelle A. Faunce

  DOI：10.1055/s-1987-28013

  日期：——

  The addition reaction of 2,4-bis(methylthio)pyrimidine or 2, 4-dimethoxypyrimidine with organolithium reagents produces unstable 6-substituted 2,4-bis(methylthio)-5,6-dihydropyrimidines and 2, 4-dimethoxy-5,6-dihydropyrimidines, respectively. The regioselective hydrolysis of these addition products gives the respective 6-substituted 2-methylthio-5,6-dihydropyrimidin-4(3H)ones and 6-substituted 2-methoxy-5,6-dihydropyrimidin-4(3H)ones. The methoxy products can be hydrolyzed further to 6-substituted dihydrouracils.

  2,4-双（甲硫基）嘧啶或2,4-二甲氧基嘧啶与有机锂试剂的加成反应生成不稳定的6-取代2,4-双（甲硫基）-5,6-二氢嘧啶和2,4-二甲氧基-5,6-二氢嘧啶。对这些加成产物进行区域选择性水解可得到相应的6-取代2-甲硫基-5,6-二氢嘧啶-4（3H）酮和6-取代2-甲氧基-5,6-二氢嘧啶-4（3H）酮。甲氧基产物可以进一步水解为6-取代二氢尿嘧啶。
• A Different Role of Meldrum's Acid in the Biginelli Reaction
  作者：Jan Svĕtlík、Lucia Veizerová

  DOI：10.1002/hlca.201000193

  日期：2011.2

  A Biginelli‐type condensation using Meldrum's acid has been accomplished in refluxing AcOH to give 6‐substituted dihydropyrimidine‐2,4‐(1H,3H)‐diones. In contrast to other aldehydes, the three‐component reaction with salicylaldehyde led to an oxygen‐bridged pyridine. A reaction mechanism is proposed.

  使用Meldrum酸进行的Biginelli型缩合反应已在回流的AcOH中完成，得到了6个取代的二氢嘧啶-2,4-（1 H，3 H）-二酮。与其他醛相反，与水杨醛的三组分反应导致氧桥联吡啶。提出了一种反应机理。
• Therapeutic compounds for treating dyslipidemic conditions
  申请人：Jones Brian A.

  公开号：US20050239769A1

  公开（公告）日：2005-10-27

  The present invention relates to novel LXR ligands of Formula I and the pharmaceutically acceptable salts, esters and tautomers thereof, which are useful in the treatment of dyslipidemic conditions, particularly depressed levels of HDL cholesterol.

  本发明涉及公式I的新型LXR配体及其药学上可接受的盐、酯和互变异构体，其在治疗脂质代谢异常症状，特别是低下的高密度脂蛋白胆固醇水平中有用。