2-(2-nitrophenyl)-1,3,4-thiadiazole | 353498-24-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2-nitrophenyl)-1,3,4-thiadiazole
• 英文别名: (2-nitro-phenyl)-[1,3,4]thiadiazole；(2-Nitro-phenyl)-[1,3,4]thiadiazol
• CAS: 353498-24-5
• 化学式: C₈H₅N₃O₂S
• 分子量: 207.213
• InChiKey: RVIKHNSRMLDCSM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  99.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-(2-nitrophenyl)-1,3,4-thiadiazole 在 盐酸 、 铁粉 、 氯化铵 、 sodium nitrite 作用下， 生成 2-(2-hydroxyphenyl)-1,3,4-thiadiazole
  参考文献：
  名称：

  Ohta et al., Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1953, vol. 73, p. 701,703

  摘要：

  DOI：
• 作为产物：
  描述：

  thioformic acid N'-benzoyl-hydrazide 在 硫酸 、 硝酸 作用下， 生成 2-(2-nitrophenyl)-1,3,4-thiadiazole
  参考文献：
  名称：

  Ohta et al., Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1953, vol. 73, p. 701,703

  摘要：

  DOI：

文献信息

• [EN] AMIDE DERIVATIVES AS SIRTUIN MODULATORS<br/>[FR] DÉRIVÉS D'AMIDE COMME MODULATEURS DE SIRTUINES
  申请人：SIRTRIS PHARMACEUTICALS INC

  公开号：WO2009058348A1

  公开（公告）日：2009-05-07

  Provided herein are novel sirtuin-modulating compounds represented by Structural Formula (I) and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin- modulating compound in combination with another therapeutic agent.

  提供的是由结构公式（I）表示的新的sirtuin调节化合物及其用途。sirtuin调节化合物可用于延长细胞寿命，以及治疗和/或预防多种疾病和紊乱，例如与衰老或压力、糖尿病、肥胖、神经退行性疾病、心血管疾病、凝血障碍、炎症、癌症和/或潮红相关的疾病或紊乱，以及将从增加线粒体活性中受益的疾病或紊乱。还提供了包含sirtuin调节化合物与另一种治疗剂的组合的药物组合物。
• COMPOUNDS AND METHODS FOR TREATING CANCER
  申请人：ANTIDOTE IP HOLDINGS, LLC

  公开号：US20200299282A1

  公开（公告）日：2020-09-24

  Substituted cinnamamide compounds and analogs, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat, prevent or ameliorate cancer are provided.

  提供了替代肉桂酰胺化合物和类似物、制备这类化合物的方法、包含这类化合物的药物组合物和药物、以及使用这类化合物治疗、预防或改善癌症的方法。
• Lincomycin Derivatives and Antimicrobial Agents Comprising the Same as Active Ingredient
  申请人：Umemura Eijirou

  公开号：US20090156512A1

  公开（公告）日：2009-06-18

  This invention provides compounds of formula (I) or its pharmacologically acceptable salt or solvate, wherein A represents aryl or a monocyclic or bicyclic heterocyclic group, R 1 represents a halide, nitro, substituted C 1-6 alkyl, optionally substituted amino, C 1-6 alkyloxycarbonyl, optionally substituted aryl, a heterocyclic group, or heterocyclic carbonyl, R 2 represents a hydrogen atom or C 1-6 alkyl, R 3 represents C 1-6 alkyl, all of R 4 , R 5 , and R 6 represent a hydrogen atom, R 7 represents C 1-6 alkyl, m is 1 or 2, and n is 1. The compounds are novel lincomycin derivatives having a potent activity against resistant pneumococci. The compounds can be used as an antimicrobial agent and are useful for preventing or treating bacterial infectious diseases.

  本发明提供了式（I）的化合物或其药理学上可接受的盐或溶剂，其中A代表芳基或单环或双环杂环基，R1代表卤素、硝基、取代的C1-6烷基、可选取代的氨基、C1-6烷氧羰基、可选取代的芳基、杂环基或杂环羰基，R2代表氢原子或C1-6烷基，R3代表C1-6烷基，R4、R5和R6均代表氢原子，R7代表C1-6烷基，m为1或2，n为1。这些化合物是新型的林可霉素衍生物，对耐药性肺炎球菌具有强大的活性。这些化合物可以用作抗微生物剂，并且对于预防或治疗细菌感染性疾病是有用的。
• AMIDE DERIVATIVES AS SIRTUIN MODULATORS
  申请人：Oalmann Christopher

  公开号：US20110039847A1

  公开（公告）日：2011-02-17

  Provided herein are novel sirtuin-modulating compounds represented by Structural Formula (I) and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

  本文提供了由结构式（I）所代表的新型sirtuin调节化合物及其使用方法。这些sirtuin调节化合物可用于增加细胞寿命，并治疗和/或预防各种疾病和障碍，包括与衰老或压力有关的疾病或障碍、糖尿病、肥胖症、神经退行性疾病、心血管疾病、血液凝固障碍、炎症、癌症和/或潮红症，以及需要增加线粒体活性的疾病或障碍。此外，还提供了含有sirtuin调节化合物与另一种治疗剂的组合物。
• Herbicidal sulfamates
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0096593A2

  公开（公告）日：1983-12-21

  Compounds of the formula where Q is selected from various 5-membered heterocycles, which may optionally be substituted; R is H, halogen, CH3, CF3, or OCH3; X is Cl, CH3, OCH3, OCF2H or SCF2H; Y is selected from various organic groups; and Z is CH or H, and their agriculturally suitable salts, exhibit potent herbicidal and plant growth regulant effects. The compounds may be formulated into herbicidal compositions in conventional manner. The novel compounds may be prepared by reacting an appropriate aryloxysulfonyl isocyanate with the appropriate 2-amino-pyrimidine or 2-amino-1,3,5-triazine.

  式中的化合物 其中 Q 选自各种五元杂环，可任选被取代； R 是 H、卤素、CH3、CF3 或 OCH3； X 是 Cl、CH3、OCH3、OCF2H 或 SCF2H； Y 选自各种有机基团；以及 Z 是 CH 或 H、 以及它们在农业上适用的盐类，具有强效的除草和植物生长调节作用。这些化合物可按常规方法配制成除草组合物。 新型化合物可通过适当的芳氧基磺酰基异氰酸酯与适当的 2-氨基嘧啶或 2-氨基-1,3,5-三嗪反应制备。