2-(carbomethoxymethylamino)ethylidene-1,1-diphosphonic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(carbomethoxymethylamino)ethylidene-1,1-diphosphonic acid
• 英文别名: 2-(2,2-Diphosphonoethylamino)acetic acid
• 化学式: C₄H₁₁NO₈P₂
• 分子量: 263.081
• InChiKey: LEICJYHECSZEAS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.4
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  164
• 氢给体数：
  6
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  vinylidene-1,1-diphosphonic acid 、 聚甘氨酸 在 sodium hydroxide 作用下， 反应 7.0h， 生成 2-(carbomethoxymethylamino)ethylidene-1,1-diphosphonic acid
  参考文献：
  名称：

  Reactions of vinylidenediphosphonic acid with nucleophiles. 4. Addition of amino acids, diastereotopy of phosphorus atoms in the addition products

  摘要：

  Previously unknown carboxy-substituted 2-alkylaminoethylidene-1,1-diphosphonic acids were synthesized by the reaction of vinylidenediphosphonic acid with amino acids. The reaction products, containing chiral centers, show nonequivalence of the phosphorus atoms in the P-31 NMR spectra as a result of diestereotopy.

  DOI：

  10.1007/bf00863598

文献信息

• ALFEREV I. S.; KOTLYAREVSKIJ I. L.; MIXALIN N. V.; NOVIKOVA V. M., IZV. AN CCCP CEP. XIM., 1980 HO 5, 1211-1212
  作者：ALFEREV I. S.、 KOTLYAREVSKIJ I. L.、 MIXALIN N. V.、 NOVIKOVA V. M.

  DOI：——

  日期：——
• Reactions of vinylidenediphosphonic acid with nucleophiles. 4. Addition of amino acids, diastereotopy of phosphorus atoms in the addition products
  作者：I. S. Alfer'ev、N. V. Mikhalin

  DOI：10.1007/bf00863598

  日期：1992.9

  Previously unknown carboxy-substituted 2-alkylaminoethylidene-1,1-diphosphonic acids were synthesized by the reaction of vinylidenediphosphonic acid with amino acids. The reaction products, containing chiral centers, show nonequivalence of the phosphorus atoms in the P-31 NMR spectra as a result of diestereotopy.