4-Methylsulfanylbutylbenzene | 960593-26-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Methylsulfanylbutylbenzene
• CAS: 960593-26-4
• 化学式: C₁₁H₁₆S
• 分子量: 180.314
• InChiKey: BOWRUZNKAKDPTJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-Methylsulfanylbutylbenzene 、 vinylidene-1,1-diphosphonic acid 在 三氟乙酸 作用下， 以70%的产率得到Hydroxy-[2-[methyl(4-phenylbutyl)sulfonio]-1-phosphonoethyl]phosphinate
  参考文献：
  名称：

  Activity of Sulfonium Bisphosphonates on Tumor Cell Lines

  摘要：

  We investigated three series of sulfonium bisphosphonates for their activity in inhibiting the growth of three human tumor cell lines. The first series consisted of 6 cyclic sulfonium bisphosphonates, the most active species having an (average) IC50 of 89,mu M. The second consisted of 10 phenylalkyl and phenylalkoxy bisphosphonates, the most active species having an IC50 of 18,mu M. The third series consisted of 17 n-alkyl sulfonium bisphosphonates, the most active species having an IC50 of similar to 240 nM. Three QSAR models showed that the experimental cell growth inhibition results could be well predicted. We also determined the structures of one sulfonium bisphosphonate bound to farnesyl diphosphate synthase, finding that it binds exclusively to the dimethylallyl diphosphate binding site. These results are of interest since they show that sulfonium bisphosphonates can have potent activity against a variety of tumor cell lines, the most active species having IC50 values much lower than conventional nitrogen-containing bisphosphonates.

  DOI：

  10.1021/jm700991k
• 作为产物：
  描述：

  二甲基二硫 、 4-苯基-1-丁烯 在 4DPAIPN 、 cesium formate 、 硫代水杨酸甲酯 作用下， 以 氘代二甲亚砜 为溶剂， 生成 4-Methylsulfanylbutylbenzene
  参考文献：
  名称：

  Radical Hydrocarboxylation of Unactivated Alkenes via Photocatalytic Formate Activation

  摘要：

  DOI：

  10.1021/jacs.3c03671

文献信息

• Inhibitors of c-Jun N-terminal kinases
  申请人：Liu Gang

  公开号：US20060173050A1

  公开（公告）日：2006-08-03

  The present invention relates to compounds that are inhibitors of c-jun N-terminal kinase 1, 2, or 3 (JNK1, JNK2, or JNK3), compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by the activation of JNK1, JNK2 and JNK3.

  本发明涉及作为c-jun N-末端激酶1、2或3（JNK1、JNK2或JNK3）抑制剂的化合物，包含这些化合物的组合物以及这些化合物在预防或治疗由JNK1、JNK2和JNK3激活调控的疾病中的用途。
• Pyrimidine derivatives as ghrelin receptor modulators
  申请人：Kosogof Christi

  公开号：US20050070712A1

  公开（公告）日：2005-03-31

  The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by ghrelin including anorexia, cancer cachexia, eating disorders, age-related decline in body composition, weight gain, obesity, and diabetes mellitus.

  本发明涉及式(I)的化合物，或者其治疗上适宜的盐或前药，该化合物的制备、含有该化合物的组合物以及在预防或治疗由生长激素释放素调节的疾病中使用该化合物，包括厌食症、癌症恶病质、进食障碍、与年龄相关的身体组成下降、体重增加、肥胖和糖尿病。
• Diaminopyrimidine derivatives as growth hormone secrectgogue receptor (GHS-R) antagonists
  申请人：Kosogof Christi

  公开号：US20050171131A1

  公开（公告）日：2005-08-04

  The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by the action of ghrelin receptor, including Prader-Willi syndrome, eating disorder, weight gain, weight-loss maintainance following diet and exercise, obesity, and disorders associated with obesity such as noninsulin dependent diabetes mellitus.

  本发明涉及式(I)的化合物，或其治疗上适用的盐或前药，所述化合物的制备，含有所述化合物的组合物以及在预防或治疗由胃泌素受体调节的疾病中使用所述化合物，包括普拉德-威利综合征、进食障碍、体重增加、饮食和锻炼后体重减轻维持、肥胖，以及与肥胖相关的疾病，如非胰岛素依赖型糖尿病。
• Diaminopyrimidine derivatives as selective growth hormone secrectgogue receptor (GHS-R) antagonists
  申请人：Xin Zhili

  公开号：US20050171132A1

  公开（公告）日：2005-08-04

  The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by the action of ghrelin receptor, including Prader-Willi syndrome, eating disorder, weight gain, weight-loss maintainance following diet and exercise, obesity and disorders associated with obesity such as non-insulin dependent diabetes mellitus.

  本发明涉及式（I）的化合物，或其治疗上适宜的盐或前药，以及该化合物的制备、含有该化合物的组合物以及在预防或治疗由胃饥饿素受体调节的疾病中使用该化合物，包括普拉德-威利综合症、进食障碍、体重增加、饮食和运动后体重减轻维持、肥胖症以及与肥胖症相关的疾病，如非胰岛素依赖性糖尿病。
• BRIDGED METALLOCENE COMPOUND, OLEFIN POLYMERIZATION CATALYST CONTAINING THE SAME, AND ETHYLENE POLYMER OBTAINED WITH THE CATALYST
  申请人：Prime Polymer Co., Ltd.

  公开号：US20140114031A1

  公开（公告）日：2014-04-24

  Metallocene compounds of the invention are useful as olefin polymerization catalysts or catalyst components. Olefin polymerization processes of the invention involve an olefin polymerization catalyst containing the metallocene compound. In detail, the olefin polymerization catalysts can catalyze with high polymerization activity the production of olefin polymers having high melt tension, excellent mechanical strength and good particle properties, and the olefin polymerization processes involve the catalysts. Ethylene polymers according to the invention are obtained by the polymerization processes and have higher processability and easy-opening properties and particularly excellent mechanical strength compared to conventional ethylene polymers. Thermoplastic resin compositions of the invention contain the ethylene polymers. In more detail, shaped articles or films are obtained from the ethylene polymers or the thermoplastic resin compositions containing the ethylene polymers, and laminate films include the films. According to the invention, a single or plural kinds of bridged metallocene compounds having differing cyclopentadienyl-derived groups afford macromonomers that are a source of long-chain branches and simultaneously catalyze the repolymerization of the macromonomers into olefin polymers having a large number of long-chain branches, small neck-in in the T-die extrusion, small take-up surge and superior mechanical strength. The olefin polymerization catalysts and the polymerization processes can efficiently produce the olefin polymers.

  本发明的金属茂化合物可用作烯烃聚合催化剂或催化剂组分。本发明的烯烃聚合工艺涉及含有金属茂化合物的烯烃聚合催化剂。具体而言，该烯烃聚合催化剂可以高效地催化生产具有高熔融张力、优异机械强度和良好颗粒特性的烯烃聚合物，并且该烯烃聚合工艺涉及该催化剂。本发明的乙烯聚合物是通过聚合工艺获得的，与传统的乙烯聚合物相比，具有更高的加工性能和易开口性能，特别是具有优异的机械强度。本发明的热塑性树脂组合物包含乙烯聚合物。更具体地说，从乙烯聚合物或包含乙烯聚合物的热塑性树脂组合物中获得成型件或薄膜，并且层压膜包括薄膜。根据本发明，具有不同环戊二烯基衍生物的单个或多种桥联金属茂化合物提供了长链支链的来源，同时催化了大量长链支链的重聚合成烯烃聚合物，具有大量长链支链、T型模头挤出小颈缩、小收缩和优异的机械强度。该烯烃聚合催化剂和聚合工艺可以高效地生产烯烃聚合物。