2-diphenylmethylenebutanedioic anhydride | 18356-30-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-diphenylmethylenebutanedioic anhydride
• 英文别名: benzhydrylidene-succinic acid anhydride；Benzhydryliden-bernsteinsaeure-anhydrid；2,5-Furandione, 3-(diphenylmethylene)dihydro-；3-benzhydrylideneoxolane-2,5-dione
• CAS: 18356-30-4
• 化学式: C₁₇H₁₂O₃
• 分子量: 264.28
• InChiKey: NAFBSTVYWJYRKC-UHFFFAOYSA-N

物化性质

• 熔点：
  152 °C
• 沸点：
  453.3±44.0 °C(Predicted)
• 密度：
  1.276±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-diphenylmethylenebutanedioic anhydride 在 三氯化铝 、 sodium acetate 、 硝基苯 作用下， 生成 5-acetoxy-benzo[c]fluoren-7-one
  参考文献：
  名称：

  Borsche, Justus Liebigs Annalen der Chemie, 1936, vol. 526, p. 1,21

  摘要：

  DOI：
• 作为产物：
  描述：

  benzhydrylidene-succinic acid 在 乙酰氯 作用下， 生成 2-diphenylmethylenebutanedioic anhydride
  参考文献：
  名称：

  Stobbe; Kohlmann, Justus Liebigs Annalen der Chemie, 1899, vol. 308, p. 98

  摘要：

  DOI：

文献信息

• Synthesis and Structure−Activity Relationships of a New Model of Arylpiperazines. 4. 1-[ω-(4-Arylpiperazin-1-yl)alkyl]-3-(diphenylmethylene)- 2,5-pyrrolidinediones and -3-(9<i>H</i>-fluoren-9-ylidene)-2,5-pyrrolidinediones: Study of the Steric Requirements of the Terminal Amide Fragment on 5-HT_1A Affinity/Selectivity
  作者：María L. López-Rodríguez、M. José Morcillo、Tandú K. Rovat、Esther Fernández、Bruno Vicente、Antonio M. Sanz、Medardo Hernández、Luis Orensanz

  DOI：10.1021/jm980285e

  日期：1999.1.1

  demonstrated moderate to high affinity for 5-HT1A and alpha1 receptor binding sites but had no affinity for D2 receptors. The study of the length of the alkyl chain and the imide substructure has allowed us to suggest some differences between the 5-HT1A and the alpha1-adrenergic receptors: (i) for III and IV, affinity for the 5-HT1A receptor as a function of the length of the methylene linker decreases

  在本文中，我们报告了一系列新的1- [ω-（4-芳基哌嗪-1-基）烷基] -3-（二苯基亚甲基）- 2、2-吡咯烷二酮（III）（1-4）和-3-（9H-芴-9-亚烷基）-2、5-吡咯烷二酮（IV）（1-4），其中烷基连接基包含1-4亚甲基和芳基被不同地取代。将获得的结果与先前报道的双环乙内酰脲（I）和相关双环胺（II）系列的结果进行比较。被测化合物1-4的相当一部分对5-HT1A和α1受体结合位点表现出中等至高亲和力，但对D2受体没有亲和力。对烷基链长度和酰亚胺亚结构的研究使我们提出了5-HT1A和α1-肾上腺素受体之间的一些区别：（i）对于III和IV，对5-HT1A受体的亲和力随亚甲基接头长度的变化而降低，顺序为4> 1 >> 3约2，而对α1受体的亲和力则按3顺序降低。 4> 1约2; （ii）5-HT1A受体中的无药效位阻性口袋（不保留配体的药效团但保留分子的非必需片段的受体区）
• Microwave synthesis of some new antimicrobial and antiproliferative butenamides and pyrrolidine-2,5-diones
  作者：SHADIA MAHMOUD ABDALLAH、HALIMA ALY HEFNY

  DOI：10.3906/kim-1007-807

  日期：——

  Microwave irradiation, comparable to conventional thermal heating, proves to be a convenient method in assisting the synthesis of some butenamides, pyrrolidine-2,5-diones, and their benzenesulfonamido derivatives, which are known to have biological activities and wide medical and industrial applications. Both procedures were used to compare their efficiency in synthesizing butenamides and pyrrolidine-2,5-diones (2-25), which have important and wide applications, from condensation of \alpha,\beta-unsaturated anhydride (1) with the corresponding amines. Some of the products showed biological or cytotoxic (antiproliferative) activity.

  微波辐射，与传统的热加热方法相媲美，证明是一种方便的方法，有助于合成一些丁烯酰胺、吡咯烷-2,5-二酮及其苯磺酰胺衍生物，这些化合物已知具有生物活性，并广泛用于医疗和工业应用。两种方法被用于比较其在合成丁烯酰胺和吡咯烷-2,5-二酮（2-25）方面的效率，这些化合物在重要领域具有广泛的应用，合成过程是通过与相应的胺进行\alpha,\beta-不饱和酐（1）的缩合。一些产品显示出生物或细胞毒性（抗增殖）活性。
• Marking
  申请人：COURTAULDS PLC

  公开号：EP0279600A1

  公开（公告）日：1988-08-24

  A marking comprises a layer, preferably of film-­forming material, which contains a photochromic compound. The photochromic compound is capable of changing colour when exposed to uv light, but can be converted to a perman­ently non-photochromic compound, preferably by over-­exposure to uv light. An image is formed in the layer by converting the photochromic compound to a permanently non-photochromic compound in one or more selected areas. When the layer is subsequently viewed under uv light a colourless image of non-photochromic compound can be seen on a background of coloured photochromic compound.

  标记包括一层，最好是成膜材料，其中含有一种光致变色化合物。光致变色化合物在紫外光照射下能改变颜色，但最好在紫外光过度照射下能转化为永久性的非光致变色化合物。通过在一个或多个选定区域将光致变色化合物转化为永久性非光致变色化合物，在层中形成图像。随后在紫外光下观察该层时，可以看到在彩色光致变色化合物的背景上有一个无色的非光致变色化合物图像。
• Gliotoxin. V. The Structure of Certain Indole Derivatives Related to Gliotoxin^1,2
  作者：John R. Johnson、Richard B. Hasbrouck、James D. Dutcher、William F. Bruce

  DOI：10.1021/ja01219a023

  日期：1945.3
• 1-[ω-(4-Arylpiperazin-1-yl)alkyl]-3-diphenylmethylene-2,5-pyrrolidinediones as 5-HT1A receptor ligands: Study of the steric requirements of the terminal amide fragment on 5-HT1A affinity/selectivity
  作者：María L López-Rodríguez、M.José Morcillo、TandúK Rovat、Esther Fernández、Antonio M Sanz、Luis Orensanz

  DOI：10.1016/s0960-894x(98)00074-2

  日期：1998.3

  In the present paper, we report the synthesis and the binding profile on 5-HT1A, alpha(1), and D-2 receptors of a new series of imide-arylpiperazines 3. The study oft he length of the alkyl chain and the imide substructure allows us to suggest some important differences between the no-pharmacophoric sites of both 5-HT1A and alpha(1)-adrenergic receptors, which could be of great importance in order to design new selective ligands. (C) 1998 Elsevier Science Ltd. All rights reserved.