1-Tert-butyl-3-diphenylphosphoryl-5-methoxybenzene | 1047661-28-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Tert-butyl-3-diphenylphosphoryl-5-methoxybenzene
• 英文别名: 1-tert-butyl-3-diphenylphosphoryl-5-methoxybenzene
• CAS: 1047661-28-8
• 化学式: C₂₃H₂₅O₂P
• 分子量: 364.424
• InChiKey: HRDMNLUJIUIJCR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-Tert-butyl-3-diphenylphosphoryl-5-methoxybenzene 在 lithium diisopropyl amide 、 碘 作用下， 以76%的产率得到5-Tert-butyl-1-diphenylphosphoryl-2-iodo-3-methoxybenzene
  参考文献：
  名称：

  Axially 4,4′-di-tert-butyl TunePhos-type chiral diphosphine ligand: synthesis and applications in asymmetric hydrogenation

  摘要：

  Axially 4,4'-di-tert-butyl TunePhos-type chiral diphosphine ligand was designed and synthesized by means of central-to-axial chirality transfer. Up to 99% and 98% ee have been achieved in Ru-catalyzed hydrogenation of beta-alkyl and beta-aryl-substituted beta-keto esters, respectively. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.12.057
• 作为产物：
  描述：

  1,3-二溴-5-(1,1-二甲基乙基)苯 在 双氧水 、 magnesium 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 生成 1-Tert-butyl-3-diphenylphosphoryl-5-methoxybenzene
  参考文献：
  名称：

  Axially 4,4′-di-tert-butyl TunePhos-type chiral diphosphine ligand: synthesis and applications in asymmetric hydrogenation

  摘要：

  Axially 4,4'-di-tert-butyl TunePhos-type chiral diphosphine ligand was designed and synthesized by means of central-to-axial chirality transfer. Up to 99% and 98% ee have been achieved in Ru-catalyzed hydrogenation of beta-alkyl and beta-aryl-substituted beta-keto esters, respectively. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.12.057

文献信息

• Axially 4,4′-di-tert-butyl TunePhos-type chiral diphosphine ligand: synthesis and applications in asymmetric hydrogenation
  作者：Chun-Jiang Wang、Chu-Bei Wang、Dong Chen、Guangfu Yang、Zhengshun Wu、Xumu Zhang

  DOI：10.1016/j.tetlet.2008.12.057

  日期：2009.3

  Axially 4,4'-di-tert-butyl TunePhos-type chiral diphosphine ligand was designed and synthesized by means of central-to-axial chirality transfer. Up to 99% and 98% ee have been achieved in Ru-catalyzed hydrogenation of beta-alkyl and beta-aryl-substituted beta-keto esters, respectively. (C) 2008 Elsevier Ltd. All rights reserved.