N⁶,N⁶-dimethyl-DL-lysine | 19728-74-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N⁶,N⁶-dimethyl-DL-lysine
• 英文别名: N⁶,N⁶-Dimethyl-DL-lysin；DL-N^ε,N^ε-Dimethyl-lysin；N^ε-Dimethyllysin；2-Amino-6-(dimethylamino)hexanoic acid
• CAS: 19728-74-6
• 化学式: C₈H₁₈N₂O₂
• 分子量: 174.243
• InChiKey: XXEWFEBMSGLYBY-UHFFFAOYSA-N

物化性质

• 熔点：
  243-245 °C (decomp)
• 沸点：
  290.9±35.0 °C(Predicted)
• 密度：
  1.046±0.06 g/cm3(Predicted)
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  66.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  邻苯二甲醛 、 N⁶,N⁶-dimethyl-DL-lysine 生成 (2S)-6-(dimethylamino)-2-isoindol-2-ylhexanoic acid
  参考文献：
  名称：

  PARK, KWANG SOOK;LEE, HYANG WOO;HONG, SUNG-YOUL;SHIN, SOOK;KIM, SANGDUK;P+, J. CHROMATOGR., 440,(1988) 225-230

  摘要：

  DOI：
• 作为产物：
  描述：

  N^α-Benzoyllysine 在 barium dihydroxide 作用下， 生成 N⁶,N⁶-dimethyl-DL-lysine
  参考文献：
  名称：

  Poduska, Collection of Czechoslovak Chemical Communications, 1959, vol. 24, p. 1025

  摘要：

  DOI：

文献信息

• PHENYLQUINAZOLINE DERIVATIVES
  申请人：Eggenweiler Hans-Michael

  公开号：US20130178443A1

  公开（公告）日：2013-07-11

  Novel quinazolinamide derivatives of the formula (I), in which R1-R43 and X have the meanings indicated in claim 1 , are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.

  化合物(I)的新型喹唑啉酰胺衍生物，其中R1-R43和X具有权利要求书中指示的含义，是HSP90抑制剂，可用于制备用于治疗HSP90在疾病的抑制、调节和/或调控中发挥作用的药物。
• [EN] CONJUGATES COMPRISING CELL-BINDING AGENTS AND CYTOTOXIC AGENTS<br/>[FR] CONJUGUÉS COMPRENANT DES AGENTS DE LIAISON CELLULAIRE ET DES AGENTS CYTOTOXIQUES
  申请人：IMMUNOGEN INC

  公开号：WO2016036794A1

  公开（公告）日：2016-03-10

  The invention relates to novel cell-binding agent-cytotoxic agent conjugates, wherein the cell-binding agent (CBA) is covalently linked to the cytotoxic agent through an aldehyde group obtained from oxidation of a 2-hydroxyethylamine moiety on the CBA. The invention also provides methods of preparing the conjugates of the present invention. The invention further provides composition and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the conjugates of the invention.

  该发明涉及一种新型细胞结合剂-细胞毒剂偶联物，其中细胞结合剂（CBA）通过氧化CBA上的2-羟乙胺基团得到的醛基与细胞毒剂共价连接。该发明还提供了制备本发明偶联物的方法。该发明还提供了使用该发明的偶联物抑制异常细胞生长或治疗哺乳动物增生性疾病的组合物和方法。
• Compounds Useful as Immunomodulators
  申请人：Bristol-Myers Squibb Company

  公开号：US20150291549A1

  公开（公告）日：2015-10-15

  The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

  本公开涉及一般用作免疫调节剂的化合物。提供的是包含这些化合物的化合物、组合物以及它们的使用方法。本公开还涉及包含至少一种根据本公开的化合物的药物组合物，用于治疗各种疾病，包括癌症和传染病。
• [EN] CONJUGATES OF CYSTEINE ENGINEERED ANTIBODIES<br/>[FR] CONJUGUÉS D'ANTICORPS À CYSTÉINE MODIFIÉE
  申请人：IMMUNOGEN INC

  公开号：WO2017004025A1

  公开（公告）日：2017-01-05

  The invention relates to novel cell-binding agent-cytotoxic agent conjugates, wherein the cell-binding agent (CBA) is covalently linked to the cytotoxic agent through an engineered Cys, such as an engineered Cys in the heavy chain CH3 domain, at a position corresponds to the EU/OU numbering position 442 (or C442) on an antibody CBA. The invention also provides methods of preparing the conjugates of the present invention. The invention further provides composition and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the conjugates of the invention.

  本发明涉及一种新型细胞结合剂-细胞毒剂偶联物，其中所述细胞结合剂（CBA）通过工程半胱氨酸与细胞毒剂共价结合，例如在重链CH3域中的工程半胱氨酸，其位置对应于抗体CBA上的EU/OU编号位置442（或C442）。本发明还提供了制备本发明偶联物的方法。本发明还提供了使用该偶联物的组合物和方法，用于抑制异常细胞生长或治疗哺乳动物中的增生性疾病。
• Selective Sulfonation of Benzodiazepine Derivatives
  申请人：IMMUNOGEN, INC.

  公开号：US20180208562A1

  公开（公告）日：2018-07-26

  The invention relates to novel methods of preparing cell-binding agent-cytotoxic agent conjugates, wherein the cytotoxic agent is an imine-containing cytotoxic agent bearing a maleimide group. In some embodiments, the cell-binding agent (CBA) is covalently linked to the cytotoxic agent through an engineered Cys, such as an engineered Cys in the heavy chain CH3 domain, at a position corresponds to the EU/OU numbering position 442 (or C442) on an antibody CBA. The invention also provides conjugates prepared by the methods of the present invention, compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the conjugates of the invention.

  本发明涉及一种新的制备细胞结合剂-细胞毒剂结合物的方法，其中细胞毒剂是一种含有马来酰亚胺基团的亚胺类细胞毒剂。在某些实施例中，细胞结合剂（CBA）通过工程半胱氨酸与细胞毒剂共价连接，例如在抗体CBA上与EU/OU编号位置442（或C442）对应的重链CH3区域中的工程半胱氨酸处。本发明还提供了通过本发明方法制备的结合物，以及使用本发明的结合物抑制异常细胞生长或治疗哺乳动物增殖性疾病的组合物和方法。